Hematopoietic cell transplantation activity of Turkey in 2014: Ongoing increase in HCT rates

Tekgündüz, Emre; Şencan, İrfan; Kapuagasi, A.; Unal, Dogan; Öztürk, Murat; Gümüş, Eyüp; Göker, Hakan; Tavil, Emine Betül; Ertem, Mehmet; Çetın, Mustafa; Arat, Mutlu; Soysal, Teoman; Karakaşlı, Osman; Sur, Halil Yılmaz; Yeşilipek, Akif; Ferhanoğlu, Burhan; Uçkan, Duygu; İlhan, Osman; Altuntaş, Fevzi

doi:10.1016/j.transci.2016.01.013

Cited by 7 publications

(1 citation statement)

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“…Allogeneic hematopoietic cell transplantation (allo-HCT) with its curative potential is an essential treatment modality including but not restricted to haematological malignancies, bone marrow failure syndromes, immuno-deficiencies and metabolic diseases. The past two decades witnessed a global and sustained increase in the use of allo-HCT [1,2]. In adults, three-year median survival following allo-HCT is between 24-76 % according to the underlying disease [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of ovarian reserve with anti-Mullerian hormone in women following allogeneic hematopoietic cell transplantation

Kaya¹,

Tekgündüz²,

Akpınar³

et al. 2019

Clin. Exp. Obstet. Gynecol.

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Introduction: Severe ovarian failure and persistent infertility have could be seen in females following allogeneic hematopoietic cell transplantation (allo-HCT.) In this study, the authors aimed to determine the effectiveness of AMH on assessment of ovarian reserve in long-term survivors after allo-HCT. Material and Methods: Female patients, who underwent allo-HCT between August 2009 and February 2016, were retrospectively evaluated for ovarian capacity in long-term follow-up. Twenty-one female patients with a median age of 34 (22-45) years were included in the study. The serum levels of estrogen (E2), follicle stimulated hormone (FSH), luteinizing hormone (LH), and AMH were analysed. Results: The median duration of post-transplant follow-up was 37 (12-84) months. Primary ovarian failure (POF) was detected in eight (38,1%) and 19 (90,4%) cases in the pre-transplant and post-transplant period, respectively. It was found that no menstruation cycles were observed in 18 cases with low AMH levels. Discussion: Regular menstrual cycles may not guarantee the fertilization in the post-transplant period. Combined analysis of hormonal investigations, antral follicle count by vaginal USG, and evaluation of serum AMH levels may be preferred to demonstrate the presence of POF.

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Section: Introductionmentioning

confidence: 99%