Immunotherapy - Myths, Reality, Ideas, Future 2017
DOI: 10.5772/67604
|View full text |Cite
|
Sign up to set email alerts
|

Hematopoietic Cell Transplantation for Autoimmune Diseases: A Review of History, Current State, and Future Issues

Abstract: Autoimmune diseases are characterized by recurrent attacks and remissions, but as a rule they progress and eventually cause a severe disability and death. The present chapter contains general characteristics of autoimmune disease pathogenesis, ways to cause immune tolerance by hematopoietic cell transplantation (HCT), clinical aspects of the treatment for established autoimmune diseases with a special attention to multiple sclerosis (MS) and systemic sclerosis (SSc). A profound analysis of authors' point of vi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 111 publications
0
3
0
Order By: Relevance
“…These findings can potentially change the management of chronic wounds and our view of wound management in general [41,58]. Stem cells are notable due to their vast potential in solving problems of current medicine, including wound healing [45, 59-62], diseases of the nervous system [63][64][65][66][67], diabetes mellitus [68,69], Crohn's disease [70], chronic myeloid leukemia [71,72], heart failure [73,74], liver cirrhosis [75,76] and others.…”
Section: Wound Healingmentioning
confidence: 99%
“…These findings can potentially change the management of chronic wounds and our view of wound management in general [41,58]. Stem cells are notable due to their vast potential in solving problems of current medicine, including wound healing [45, 59-62], diseases of the nervous system [63][64][65][66][67], diabetes mellitus [68,69], Crohn's disease [70], chronic myeloid leukemia [71,72], heart failure [73,74], liver cirrhosis [75,76] and others.…”
Section: Wound Healingmentioning
confidence: 99%
“…In other words, stem cell transplantation has developed as a new way to salvation from different life-threatening autoimmune diseases. Indeed, cell therapy can be effective by preventing the abnormal functioning of self-activated immune cells with the help of safe and effective immune tolerance formed by transplanted cells (Rosa et al 2007 ; Resnick et al 2017 ; Del Papa et al 2018 ; Dazzi et al 2007 ; Radbruch and Thiel 2004 ). Among the various cells, mesenchymal stem cells (MSCs) (obtained from diverse tissues) are mostly known as perfect agents to the regenerative objects to represent cell multi-potency along with anti-inflammatory and powerful regenerating qualities (Larijani et al 2015 ; Han et al 2019 ; Pittenger et al 2019 ; Goodarzi et al 2018a ; Goodarzi et al 2019a ).…”
Section: Introductionmentioning
confidence: 99%
“…Mixed hematopoietic chimerism is the state of coexistence of donor- and recipient-derived hematopoietic cells in the host. Establishment of such chimerism, via allogeneic bone marrow transplantation (BMT), is a robust method for generating donor-specific tolerance to donor tissue/organs without the need for lifelong immunosuppression ( 1 – 7 ), and it can be used to treat severe autoimmune diseases ( 8 , 9 ). However, its clinical application is dampened by the toxicity of current recipient conditioning regimens.…”
Section: Introductionmentioning
confidence: 99%