Hematopoietic Function in the Elderly

Jg, Baldwin

doi:10.1001/archinte.1988.00380120014004

Cited by 28 publications

(14 citation statements)

References 15 publications

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“…This study of aging shows that the healthy elderly have normal PMN responses to G‐CSF and epinephrine but a decreased response to hydrocortisone. There is considerable data indicating that basal PMN counts are not affected by age, 26 and, to our knowledge, the effects of age on G‐CSF‐ and epinephrine‐induced PMN responses have not been previously examined. The age‐related defect in the capacity of corticosteroids (oral prednisone) and endotoxin to induce neutrophilia in the elderly has been previously described by Cream 7 and Timaffy 10 .…”

Section: Discussionmentioning

confidence: 97%

Aging and Marrow Neutrophil Reserves

Chatta

Price

Stratton

et al. 1994

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 97%

Aging and Marrow Neutrophil Reserves

Chatta

Price

Stratton

et al. 1994

J American Geriatrics Society

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“…A more general decline in hematopoietic reserve capacity in the elderly was described (Lipschitz and Udupa, 1986). Baldwin (1988) supported this conclusion, but with the caution that comorbidities significantly influence the hematopoietic status of the elderly (Lipschitz, 1995). Steady state hematopoiesis was adequate in the majority of the elderly, but the ability to respond to stress such as chemotherapy was compromised (Chatta et al, 1994; Chatta and Dale, 1996; Balducci, 2001).…”

Section: Introductionmentioning

confidence: 94%

Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines

Brusnahan

McGuire

Jackson

et al. 2010

Mechanisms of Ageing and Development

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Hematological deficiencies increase with aging leading to anemias, reduced hematopoietic stress responses and myelodysplasias. This study tested the hypothesis that side population hematopoietic stem cells (SP-HSC) would decrease with aging, correlating with IGF-1 and IL-6 levels and increases in bone marrow fat. Marrow was obtained from the femoral head and trochanteric region of the femur at surgery for total hip replacement (N = 100). Whole trabecular marrow samples were ground in a sterile mortar and pestle and cellularity and fat content determined. Marrow and blood mononuclear cells were stained with Hoechst dye and the SP-HSC profiles acquired. Marrow stromal cells (MSC) were enumerated flow cytometrically employing the Stro-1 antibody, and clonally in the colony forming unit fibroblast (CFU-F) assay. Plasma levels of IGF-1 (ng/ml) and IL-6 (pg/ml) were measured by ELISA. SP-HSC in blood and bone marrow decreased with age but the quality of the surviving stem cells increased. MSC decreased non-significantly. IGF-1 levels (mean = 30.7, SEM = 2) decreased and IL-6 levels (mean = 4.4, SEM = 1) increased with age as did marrow fat (mean = 1.2 mm fat/g, SEM = 0.04). There were no significant correlations between cytokine levels or fat and SP-HSC numbers. Stem cells appear to be progressively lost with aging and only the highest quality stem cells survive.

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“…[4,5] The blunted haemopoietic response to severe infections and bone marrow insults in the elderly has been ascribed to age-related deficits in marrow progenitor cell numbers, [30] changes in the marrow microenvironmentp I ,32] decreased production of regulatory growth factors,[331 or a combination of these mechanisms. [4,5] The blunted haemopoietic response to severe infections and bone marrow insults in the elderly has been ascribed to age-related deficits in marrow progenitor cell numbers, [30] changes in the marrow microenvironmentp I ,32] decreased production of regulatory growth factors,[331 or a combination of these mechanisms.…”

Section: Age-related Changes In Lympho-haemopoiesismentioning

confidence: 99%

Aging and Haemopoiesis

Chatta

Dale

1996

Drugs & Aging

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Senescence of the lympho-haemopoietic system is associated with an increased incidence of neoplasia, autoimmune diseases and infections. Myelosuppression, either in the context of cancer chemotherapy or in the face of severe infections, commonly manifests as pancytopenia, and has an adverse impact on the prognosis of the elderly cancer patient by increasing infection and bleeding-related morbidity. The physiological basis of this blunted haemopoietic response is unclear, and has been ascribed to age-related deficits in marrow progenitor cell numbers, changes in the marrow microenvironment, decreased production of regulatory growth factors, or a combination of these mechanisms. These age-related deficits tend to be subtle and are only of clinical importance either when present cumulatively or under conditions of extreme haemopoietic stress. Furthermore, some of these deficits can be circumvented with the use of haemopoietic growth factors (HGFs). Thus, the availability in the clinic of various HGFs has had a tremendous impact on the care of the elderly cancer patient. The HGFs currently approved for use are: granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and epoetin-alpha (recombinant human erythropoietin). However, we still need to better elucidate age-related changes in the early stages of haemopoiesis. The question of haemopoietic exhaustion, particularly under prolonged growth factor stimulation, is real and still unanswered.

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Hematopoietic Function in the Elderly

Cited by 28 publications

References 15 publications

Aging and Marrow Neutrophil Reserves

Aging and Marrow Neutrophil Reserves

Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines

Aging and Haemopoiesis

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