Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase–expressing umbilical cord mesenchymal stromal cells

Gan, Jingyi; Meng, Fanwei; Zhou, Xin; Li, Chan; He, Yizhu; Zeng, Xiaoping; Jiang, Xingen; Liu, Jia; Zeng, Guifang; Tang, Yunxia; Liu, Muyun; Mrsny, Randall J.; Hu, Xiang; Hu, Ji-Fan; Li, Tao

doi:10.1016/j.jcyt.2014.11.011

Cited by 22 publications

(24 citation statements)

References 42 publications

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“…Herein, we isolated four PDSCs, including CV-MSCs, WJ-MSCs, AE-MSCs and DB-MSCs, and compared the capacity of proliferation, multi-lineage differentiation, and the efficacy in preventing ALF in mice. Previously, we found that treatment with human umbilical cord-derived mesenchymal stromal cells, either before or after acetaminophen intoxication, was able to improve the survival of mice with ALF [30]. In this proof-of-concept study, we demonstrate the role of PDSCs in the prevention of ALF.…”

Section: Discussionsupporting

confidence: 54%

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Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure

Zeng¹,

Li²,

Ju³

et al. 2015

J Stem Cell Res Ther

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Mesenchymal stem cells (MSCs) are powerful sources for cell therapy in regenerative medicine due to their capacity for self-renewal, multilineage differentiation, and immune modulation. Placenta-derived stem cells (PDSCs) have been recently suggested as alternative sources of stem cells. However, comparative studies to decide the most suitable cells for cell-based therapeutics are largely lacking. This study attempted to compare the potential of PDSCs in the treatment of mice with acute hepatic failure (ALF). We isolated four types of PDSCs, including the fetus-derived chorionic villi MSCs (CV-MSCs), Wharton's jelly umbilical cord MSCs (WJ-MSCs) and amnion MSCs (AE-MSCs), and the maternally derived decidua basalis MSCs (DB-MSCs). We found that all PDSCs showed similar biological properties, including morphology, specific surface antigen, proliferation, and multipotent differentiation potential (osteogenesis, adipogenesis and chondrogenesis). In addition, they also exhibited similar therapeutic potential in rescuing acetaminophen-induced ALF in mice, regardless of their origins. However, the fetus-derived CV-MSCs and WJ-MSCs exhibited the highest proliferative potential and the best improvement of survival rate in mice with ALF. Taken together, our data suggest that PDSCs, particularly CV-MSCs and WJ-MSCs, may have greater potential to be banked for clinical use.

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Section: Discussionsupporting

confidence: 54%

“…In a previous ALF study, we found that transplantation with human umbilical cord-derived mesenchymal stromal cells (hUCMSCs), either before or after acetaminophen intoxication, was able to improve the survival of ALF mice [30]. In this study, we focused on the role of PDSCs in the prevention of ALF.…”

Section: Animal Model and Cell Transplantationmentioning

confidence: 99%

Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure

Zeng¹,

Li²,

Ju³

et al. 2015

J Stem Cell Res Ther

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“…Moreover, MSCs therapy resulted in improved recovery of the hematopoietic system through decreased apoptosis and radiation induced oxidative stress [167,168].…”

Section: Hematopoietic System Homeostasis Radiation Injurymentioning

confidence: 99%

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

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“…We speculate that the poor proliferative potential and increased apoptosis of the SAA MSCs may be associated with their poor support. In vivo , MSC infusion has greatly benefited hematopoietic reconstitution in SAA animals . Therefore, MSC insufficiency is possibly responsible for their functionally abnormal support in SAA BM.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo, MSC infusion has greatly benefited hematopoietic reconstitution in SAA animals. [26][27][28][29] Therefore, MSC insufficiency is possibly responsible for their functionally abnormal support in SAA BM.…”

Section: Discussionmentioning

confidence: 99%

Increased apoptosis and peripheral blood mononuclear cell suppression of bone marrow mesenchymal stem cells in severe aplastic anemia

Chao

Lin

Pan

et al. 2018

Pediatric Blood & Cancer

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Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase–expressing umbilical cord mesenchymal stromal cells

Cited by 22 publications

References 42 publications

Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure

Therapeutical Comparison of Mesenchymal Stem Cells from Different Tissues of Human Placenta in the Treatment of Mice with Acute Hepatic Failure

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

Increased apoptosis and peripheral blood mononuclear cell suppression of bone marrow mesenchymal stem cells in severe aplastic anemia

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