Hematopoietic Stem Cell Transplant in Elderly Patients: Experience from a Tertiary Care Centre in Northern India

Sharma, Sanjeev; Choudhary, Deepak; Kaul, Esha; Kharya, Gaurav; Khandelwal, Vipin; Kothari, Sweta; Doval, Divya; Handoo, Anil; Setia, Rasika; Dadu, Tina; Pessi, Kirti

doi:10.1007/s12288-015-0624-0

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…However, data reporting the number of HSCT performed in older adults in low-and-middle income countries (LMICs) remain scarce. A study from a tertiary care hospital in northern India [6] reported that from 440 patients undergoing HSCT between February 2010 and August 2015, only 19 (4%) were aged ≥60 years, which is comparable to our study findings (7%).…”

Section: Discussionsupporting

confidence: 89%

Unmet need for hematopoietic stem cell transplantation in older adults in developing countries: Experience from a Latin American referral center

Rodríguez¹,

Rivera-Franco

2020

Journal of Geriatric Oncology

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Section: Discussionsupporting

confidence: 89%

Unmet need for hematopoietic stem cell transplantation in older adults in developing countries: Experience from a Latin American referral center

Rodríguez¹,

Rivera-Franco

2020

Journal of Geriatric Oncology

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“…Elderly patients and those with co-morbidities should be offered RIC allo-HSCT as it can lead long-term cure [14]. The drawback of our study, In addition to being a retrospective, was less number of patients, however, results of our study are consistent with those reported in the literature [4,7,8].…”

Section: Discussionsupporting

confidence: 81%

Myeloablative Versus Reduced Intensity Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Retrospective Analysis

Sharma

Choudhary

Doval

et al. 2020

Indian J Hematol Blood Transfus

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The conditioning regimens used for the allo-HSCT include either myeloablative conditioning (MAC) or reduced intensity conditioning (RIC) regimens based on the age, performance status and co-morbidities. Studies comparing the survival outcomes of RIC and MAC allo-HSCT in AML and MDS patients have reported contradictory results. We therefore retrospectively analyzed our data of AML and MDS patients who received MAC and RIC allo-HSCT at our center and compared the long term outcome of the two conditioning regimens. One hundred twenty six consecutive patients were evaluated, 32 (25.4%) underwent MAC allo-HSCT and 94 (74.6%) underwent RIC allo-HSCT. The most common MAC regimen used was busulfan plus cyclophosphamide and the most common RIC regimen used was fludarabine plus melphalan. The median age was higher in RIC group (44 years, range 4-75 years) compared to MAC group (31 yrs, range 6-51 yrs, p = 0.001). There was no significant difference in terms of overall survival (p = 0.498), relapse-free survival (p = 0.791) and non-relapse mortality (p = 0.366) between the two groups. In multivariate analysis, only chronic graftversus-host disease resulted in decreased risk of relapse and improved overall survival irrespective of the conditioning regimens used.

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“…Moreover, for autologous HSCT, treatment-related mortality has been documented to be lower than 5% in most studies (25). Furthermore, elderly and other high-risk patients can tolerate autologous HSCT relatively well (33)(34)(35)(36). Autologous HSCT, however, has its drawbacks as well.…”

Section: Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Sen

Thummer

2022

Front. Immunol.

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The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interactions between the residents of the various human microbiotas and the human body. Since the gut microbiota is the densest, most popular, and most studied human microbiota, the impact of other human microbiotas such as the oral, lung, urinary, and genital microbiotas is often overshadowed. However, these microbiotas also provide critical and unique insights pertaining to transplantation success, rejection risk, and overall host health, across multiple different transplantation scenarios. Organ transplantation as well as the pre-, peri-, and post-transplant pharmacological regimens patients undergo is known to adversely impact the microbiotas, thereby increasing the risk of adverse patient outcomes. Over the past decade, holistic approaches to post-transplant patient care such as the administration of clinical and dietary interventions aiming at restoring deranged microbiota community structures have been gaining momentum. Examples of these include prebiotic and probiotic administration, fecal microbial transplantation, and bacteriophage-mediated multidrug-resistant bacterial decolonization. This review will discuss these perspectives and explore the role of different human microbiotas in the context of various transplantation scenarios.

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Hematopoietic Stem Cell Transplant in Elderly Patients: Experience from a Tertiary Care Centre in Northern India

Cited by 5 publications

References 5 publications

Unmet need for hematopoietic stem cell transplantation in older adults in developing countries: Experience from a Latin American referral center

Unmet need for hematopoietic stem cell transplantation in older adults in developing countries: Experience from a Latin American referral center

Myeloablative Versus Reduced Intensity Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Retrospective Analysis

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

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