Hematopoietic stem cell transplantation (HSCT): An approach to autoimmunity

Aláez, C.; Loyola, Mariana; Murguía, Andrea; Flores, H.; Rodríguez, Araceli; Ovilla, Roberto; Ignacio, Gregorio; Amador, Raquel; Salinas, Víctor; Pérez, Francisco Sánchez; Rodríguez, Danaee; Morales, Zoila; Llinguin, Gonzalo; Vázquez, Alfredo Macías; Altamirano, Analia; Gorodezky, Clara

doi:10.1016/j.autrev.2005.06.003

Cited by 15 publications

(6 citation statements)

References 28 publications

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“…Autologous hematopoietic stem cell transplantation (HSCT) has been indicated for patients with autoimmune diseases, resulting in great success particularly in patients with SSc [4][5][6][7][8][9][10] . Autologous HSCT is one of the treatments in…”

mentioning

confidence: 99%

Immunological Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Patients with Systemic Sclerosis: Relationship Between Clinical Benefits and Intensity of Immunosuppression

Bohgaki¹,

Atsumi²,

Bohgaki³

et al. 2009

J Rheumatol

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confidence: 99%

Immunological Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Patients with Systemic Sclerosis: Relationship Between Clinical Benefits and Intensity of Immunosuppression

Bohgaki¹,

Atsumi²,

Bohgaki³

et al. 2009

J Rheumatol

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“…The main course of treatment predominantly involves suppression of the immune system; however, these agents can potentiate numerous side effects [3,4]. Autologous haematopoietic stem cell transplantation (HSCT) [5] is currently being trialled as a treatment of autoimmune diseases such as multiple sclerosis (MS) [6][7][8][9]. Although the approach can induce remission [6,10], it is associated with significant relapse rates [11,12].…”

Section: Introductionmentioning

confidence: 99%

Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease

Chung

Nasa

et al. 2010

Autoimmunity

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Haematopoietic stem cell (HSC) transfer coupled with gene therapy is a powerful approach to treating fatal diseases such as X-linked severe combined immunodeficiency. This ability to isolate and genetically manipulate HSCs also offers a strategy for inducing immune tolerance through ectopic expression of autoantigens. We have previously shown that retroviral transduction of bone marrow (BM) with vectors encoding the autoantigen, myelin oligodendrocyte glycoprotein (MOG), can prevent the induction of experimental autoimmune encephalomyelitis (EAE). However, ubiquitous cellular expression of autoantigen driven by retroviral promoters may not be the best approach for clinical translation and a targeted expression approach may be more acceptable. As BM-derived dendritic cells (DCs) play a major role in tolerance induction, we asked whether targeted expression of MOG, a target autoantigen in EAE, to DCs can promote tolerance induction and influence the development of EAE. Self-inactivating retroviral vectors incorporating the mouse CD11c promoter were generated and used to transduce mouse BM cells. Transplantation of gene-modified cells into irradiated recipients resulted in the generation of chimeric mice with transgene expression limited to DCs. Notably, chimeric mice transplanted with MOG-expressing BM cells manifest a significant delay in the development of EAE suggesting that targeted antigen expression to tolerogenic cell types may be a feasible approach to inducing antigen-specific tolerance.

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“…Hematopoietic stem cell transplantation (HSCT) refers to a treatment method that pretreats the transplant recipient through high-dose radiotherapy, chemotherapy, or other immunosuppressants, clears the tumor cells and abnormal clonal cells in the recipient, blocks the pathogenesis, and then transfuses autologous or allogeneic hematopoietic stem cells to the recipient so that the recipient can reestablish normal hematopoietic and immune functions in the body, so as to achieve the purpose of treatment [1][2][3]. Hematopoietic stem cell transplantation is widely used in the treatment of malignant hematological diseases, nonmalignant refractory hematological diseases, some solid tumors, genetic diseases, epidemic diseases, and congenital metabolic diseases and has achieved good curative effects.…”

Section: Introductionmentioning

confidence: 99%

A Novel Scientometrics Research on the Interaction between Oxidative Stress and Hematopoietic Stem Cell Transplantation Complications: From Graft-versus-Host Disease to Sepsis

Cavagnaro

Shi

2023

Oxidative Medicine and Cellular Longevity

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As major and serious complications after hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) and sepsis are the chief causes of low survival rates as well as mortality and for HSCT recipients. Although the overall treatment outcomes of HSCT have improved significantly in recent years, there is still an increased incidence rate of complications and mortality after transplantation. In the immediate past, with a deeper understanding of oxidative stress, more and more shreds of evidence have shown that it is closely related to transplantation-related sepsis. However, there is currently a precious little research on the interaction between oxidative stress and complications after HSCT, and the major mechanism has not yet been clarified. The objective of this study was to assess the internal connection between and potential mechanisms as well as visualized the scientometrics results of all important literature related to the topic. Through exhaustive scientometrics analysis, we searched and carefully screened 286 related publications from the Web of Science Core Collection (WoSCC) with “((HSCT) OR (hematopoietic stem cell transplantation)) AND (oxidative stress)” as the search strategy. Then, detailed visualization of the overall information analysis was made by scientific and rigorous bibliometrics software or website. Next, we analyzed retrieved articles extensively and then 59 publications that are relevant to this topic were selected for nuanced analysis and summary. The assessment of these studies proved the validity of the interaction between oxidative stress and complications after HSCT objectively and directly.

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Hematopoietic stem cell transplantation (HSCT): An approach to autoimmunity

Cited by 15 publications

References 28 publications

Immunological Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Patients with Systemic Sclerosis: Relationship Between Clinical Benefits and Intensity of Immunosuppression

Immunological Reconstitution after Autologous Hematopoietic Stem Cell Transplantation in Patients with Systemic Sclerosis: Relationship Between Clinical Benefits and Intensity of Immunosuppression

Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease

A Novel Scientometrics Research on the Interaction between Oxidative Stress and Hematopoietic Stem Cell Transplantation Complications: From Graft-versus-Host Disease to Sepsis

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