2013
DOI: 10.4236/scd.2013.32016
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Hematopoietic stem cells are a critical sub-population of whole bone marrow in the treatment of myocardial infarction

Abstract: Recent studies suggest that whole bone marrow (WBM) derived stem cells may facilitate recovery following myocardial infarction. However, the sub-population of WBM responsible for recovery remains uncertain. By adjusting the abundance of CD34 + LinNeg cells in human bone marrow we examined the relative significance of hematopoietic stem cells (HSC) in the recovery of cardiac function in a murine model of induced myocardial infarction. Enrichment of HSC by ~100-fold in WBM transplanted into mice significantly in… Show more

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Cited by 3 publications
(5 citation statements)
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References 63 publications
(65 reference statements)
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“…Nevertheless, some tolerance, although not ideal, was observed with CD133 + MSCs [15]. According to Davy et al [16] enrichment of autologous bone marrow CD34 + stem cells could increase the efficacy of treatments in clinical settings. Despite the fact that CD34 + cells have been the selected option for heart repair, there are also some reports of CD133 + cells applied in clinical trials showing improvement of myocardial viability and local perfusion of the infarcted zone [17][18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, some tolerance, although not ideal, was observed with CD133 + MSCs [15]. According to Davy et al [16] enrichment of autologous bone marrow CD34 + stem cells could increase the efficacy of treatments in clinical settings. Despite the fact that CD34 + cells have been the selected option for heart repair, there are also some reports of CD133 + cells applied in clinical trials showing improvement of myocardial viability and local perfusion of the infarcted zone [17][18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…We have previously demonstrated that the hematopoietic stem cell (HSC) fraction of the BM is critical to myocardial remodeling. 11 In particular, we observed an increase in the relative amount of HSCs within BM transplanted into the myocardium led to reduced fibrotic remodeling. 11 Also, as confirmed by others, 12 , 13 revascularization of the impacted area of myocardium was directly related to the quantity of HSC present in BM therapies.…”
Section: Introductionmentioning
confidence: 68%
“… 4 , 39 We previously demonstrated that despite their restricted lineage fate, human CD34 + Lin neg cells significantly enhance repair in a murine model of induced myocardial infarct. 11 To further investigate the efficacy of stem cell therapies, in this study, we chose to compare the repair capacity of human ASCs to that of BM-derived CD34 + Lin neg cells. The results presented here show that the effect of minimally processed ASCs on cardiac function and infarct size are indistinguishable from those of CD34 + Lin neg -enriched BM cells.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, Davy et al demonstrated that the HSCs lead to recovery of cardiac function in a murine model of induced MI and decrease the infract size. They proposed these effects due to paracrine effects of HSCs . The paracrine role of MSCs and HSCs in MI can be achieved by the following mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…They proposed these effects due to paracrine effects of HSCs. 45 The paracrine role of MSCs and HSCs in MI can be achieved by the following mechanisms.…”
Section: Paracrine Potentials Of Mscs and Hscsmentioning
confidence: 99%