Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation

Cui, Xiaomei; Zhu, Jing; Wu, Xiaoyan; Yang, Shengju; Yao, Xiaodong; Zhu, Weiwei; Xu, Pan

doi:10.1039/c9pp00311h

Cited by 15 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PDT, together with the photosensitizer 5-ALA, has previously been reported to induce apoptosis in fibroblasts and reduce the growth of a keloid graft. 23 It has also been observed previously that HMME-PDT treatment enhances the apoptosis rate of keloid fibroblasts. 23 In the current study, PDT and the photosensitizing agent Ph1 were investigated under different conditions and light powers both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 59%

“…23 It has also been observed previously that HMME-PDT treatment enhances the apoptosis rate of keloid fibroblasts. 23 In the current study, PDT and the photosensitizing agent Ph1 were investigated under different conditions and light powers both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 59%

“…33 Our results showed The basic healing process after PDT treatment is complex and dynamic, including biochemical, molecular and cellular actions that terminate in the re-development of impaired tissues. 23 Previous work has shown that the levels of pro-inflammatory cytokines (IL-6, IL-1β and IL-8) are markedly reduced after PDT in chronic periodontitis. 34 An earlier study has also observed the inhibition of inflammatory modulators (IL-6, IL-8 and tumor necrosis factor α (TNF-α)) after PDT in humans.…”

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Zheng¹,

Wu²,

Liu³

et al. 2021

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Zheng¹,

Wu²,

Liu³

et al. 2021

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Cai et al ( 30 ) further demonstrated that HMME-PDT could induce apoptosis of scar fibroblasts and stimulate production of caspase-3, a key enzyme in cell apoptosis. Consistently, the group of Cui ( 31 ) showed that HMME-PDT promotes fibroblast apoptosis and reduces vascular density and scarring in nude mice. The cumulative effect of two consecutive HMME-PDT sessions, which achieved good results in patients with PDL treatment history, should also be considered.…”

Section: Discussionmentioning

confidence: 67%

“…Interestingly, in terms of treatment history, favorable efficacy was achieved for all three categories of patients, suggesting no effect of PDL treatment history on efficacy of the dual HMME-PDT treatment regime. One hypothesis to explain this finding is that with repeated application, HMME-PDT improves perivascular Consistently, the group of Cui (31) showed that HMME-PDT promotes fibroblast apoptosis and reduces vascular density and scarring in nude mice. The cumulative effect of two consecutive HMME-PDT sessions, which achieved good results in patients with PDL treatment history, should also be considered.…”

Section: Discussionmentioning

confidence: 86%

Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains: Multivariate Analysis of Clinical Efficacy and Optical Coherence Tomography Appearance

et al. 2022

View full text Add to dashboard Cite

BackgroundHemoporfin-mediated photodynamic therapy (HMME-PDT) is reported to be effective and safe for port-wine stains (PWS). However, its efficacy is influenced by several factors and there is no appropriate method to evaluate efficacy so far. Therefore, this study explored the clinical efficacy of HMME-PDT for PWS on the face and neck and the feasibility of evaluating treatment potency with optical coherence tomography (OCT).MethodsA total of 211 PWS patients subjected to HMME-PDT were recruited for study and correlations of therapeutic effect with treatment sessions, age, gender, lesion distribution and treatment history analyzed. OCT was utilized for quantitative analysis of PWS lesions of 36 selected patients before and after HMME-PDT.ResultsThe efficacy of two consecutive treatments was significantly higher than that of single treatment (P < 0.05). In multivariate analysis, after the first treatment, age, lesion distribution and treatment history were correlative factors affecting treatment efficacy (P < 0.05). The improvement effect on central facial lesions was lower than that on lateral facial lesions (P < 0.05). The efficacy of therapy on the group with no history of pulsed dye laser (PDL) treatment was greater than that on effective and ineffective treatment groups (P < 0.05). After the second session, age remained the only factor correlated with efficacy (P < 0.05). Dilated vessel diameter and depth before and after treatment were significantly different (P < 0.05). With increasing treatment times, age was the most significant factor influencing treatment efficacy.ConclusionsOur collective findings indicate that HMME-PDT therapy is effective and safe for PWS and support the utility of OCT in objective assessment of the efficacy of HMME-PDT.

show abstract

N‐Phenyl‐2‐Pyridone‐Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by Three‐Pronged Action**

Wang,

Wu,

Liu

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

We report an endoperoxide compound (E5) which can deliver three therapeutic components by a thermal cycloreversion, namely, singlet oxygen, triplet oxygen and 3‐methyl‐N‐phenyl‐2‐pyridone, thus targeting multiple mechanisms for treating non‐small cell lung cancer and idiopathic pulmonary fibrosis. In aqueous environment, E5 undergoes clean reaction to afford three therapeutic components with a half‐life of 8.3 hours without the generation of other by‐products, which not only achieves good cytotoxicity toward lung cancer cells and decreases the levels of HIF‐1α protein, but also inhibits the TGF‐β1 induced fibrosis in vitro. In vivo experiments also demonstrated the efficacy of E5 in inhibiting tumor growth and relieving idiopathic pulmonary fibrosis, while exhibiting good biocompatibility. Many lines of evidence reveal the therapeutic efficacy of singlet oxygen and 3‐methyl‐N‐phenyl‐2‐pyridone, and triplet oxygen could downregulate HIF‐1α and relieve tumor hypoxia which is a critical issue in conventional PDT. Unlike other combination therapies, in which multiple therapeutic agents are given in independent formulations, our work demonstrates single molecule endoperoxide prodrugs could be developed as new platforms for treatment of cancers and related diseases.

show abstract

Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation

Abstract: Photodynamic therapy (PDT) has been shown to significantly inhibit fibroblast activity.

Cited by 15 publications

References 38 publications

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis

Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains: Multivariate Analysis of Clinical Efficacy and Optical Coherence Tomography Appearance

N‐Phenyl‐2‐Pyridone‐Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by Three‐Pronged Action**

Contact Info

Product

Resources

About