Hematospermia is rarely associated with urologic malignancy: Analysis of United States claims data

Abstract

Background: Hematospermia is an alarming symptom and can cause significant patient distress, but work-up is often negative.Objective: To characterize the clinical evaluation of hematospermia and its association with the diagnosis of urologic malignancy. Materials and methods:Using MarketScan insurance claims database, we identified adult males 18-64 years old diagnosed with hematospermia from 2010 to 2018. Benign hematospermia was defined as the absence of hematuria and elevated prostate-specific antigen. Patients with urologic cancer prior to diagnosis of hematospermia were excluded. We identified those who were diagnosed with a urologic malignancy.

Comprehensive evaluation of hematospermia in patients with acute epididymitis compared to patients with isolated hematospermia

“…Nevertheless, recent insurance data from the United States report an incidence of 73.6 per 100,000 in 2018, with 0.08% of cases attributable to urological cancer. 2 This finding is consistent with another study that reported on a large prostate cancer screening population (n = 26,126) in which hematospermia was found to be 0.5%. 3 In a recent meta-analysis of a total of 20 studies, the etiology of hematospermia remained unknown in 52% of cases.…”

“…The incidence of hematospermia is quite unclear, as most ejaculations during sexual intercourse go unnoticed. Nevertheless, recent insurance data from the United States report an incidence of 73.6 per 100,000 in 2018, with 0.08% of cases attributable to urological cancer 2 . This finding is consistent with another study that reported on a large prostate cancer screening population ( n = 26,126) in which hematospermia was found to be 0.5% 3 .…”