HEMATURIA AND URINARY BLADDER LESIONS COMPATIBLE WITH BRACKEN FERN (<i>PTERIDIUM AQUILINUM</i>) INTOXICATION IN CAPTIVE FALLOW DEER (<i>DAMA DAMA</i>)

Scala, Christopher; Ortiz, Katia; Catinaud, Jérôme; Lemberger, Karin

doi:10.1638/2013-0274r1.1

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…41 In this context, it is worthwhile remembering that urinary bladder tumors caused by ptaquiloside, 1, intoxication have recently been described, for the first time, in captive fallow deer. 42 Furthermore, a novel syndrome characterized by intestinal adenocarcinomas in adult farmed Sika deer that have grazed on bracken-infested pastures has just been described. Therefore, it has been suggested that ptaquiloside, 1, plays a crucial role in deer intestinal tumorigenesis too.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Ptaquiloside, the Major Carcinogen of Bracken Fern, in the Pooled Raw Milk of Healthy Sheep and Goats: An Underestimated, Global Concern of Food Safety

Virgilio

Sinisi

Russo

et al. 2015

J. Agric. Food Chem.

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Bracken fern (Pteridium aquilinum) is a worldwide plant containing toxic substances, which represent an important chemical hazard for animals, including humans. Ptaquiloside, 1, a norsesquiterpenoid glucoside, is the major carcinogen of bracken detected in the food chain, particularly in the milk from farm animals. To date, ptaquiloside has been shown in the milk of cows feeding on a diet containing bracken fern. This is the first study that shows the systematic detection of ptaquiloside, 1, and reports its direct quantitation in pooled raw milk of healthy sheep and goats grazing on bracken. Ptaquiloside, 1, was detected by a sensitive method based on the chemical conversion of ptaquiloside, 1, into bromopterosine, 4, following gas chromatography-mass spectrometry (GC-MS) analysis. The presence of ptaquiloside, 1, possibly carcinogenic to humans, in the milk of healthy animals is an unknown potential health risk, thus representing a harmful and potential global concern of food safety.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Ptaquiloside, the Major Carcinogen of Bracken Fern, in the Pooled Raw Milk of Healthy Sheep and Goats: An Underestimated, Global Concern of Food Safety

Virgilio

Sinisi

Russo

et al. 2015

J. Agric. Food Chem.

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“…Great eagle fern (Pteridium aquilinum), also called bracken fern, is an invasive plant that grows globally in very diverse environments and is difficult control in pastures [7]. Intoxication following ingestion is well documented in ruminants, including cattle, sheep and wild cervids [8,9]. In cattle, bracken fern ingestion causes enzootic haematuria, characterized by lower urinary tract haemorrhages and neoplasms of epithelial and mesenchymal origin [9].…”

Section: Introductionmentioning

confidence: 99%

A case of eagle fern (Pteridium aquilinum) poisoning on a pig farm

et al. 2021

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Background Free-range pig farming represents a minor proportion of pig production in France but is attracting an increasing number of farmers because of societal expectations and the opportunity to use pasture-grazed forage. However, this type of farming faces several challenges, including biosecurity, parasitic management, and contact with wild fauna and pathogenic flora. Case presentation Two Gascon pigs raised on an outdoor fattening farm in the Hautes-Pyrenees department of France were submitted after sudden death for necropsy at the National Veterinary School of Toulouse. The pigs were of two different breeds but from the same group of 85 animals that had grazed on a 4-ha plot of land being used for grazing for the first time. Based on an in-depth interview with the farmer, the epidemiological information available, and the necropsy and histology examinations, a hypothesis of great eagle fern intoxication was proposed. Although the sample of animals available for diagnosis was small, the success of the administered therapy confirmed our diagnosis. It was recommended that in the short term, the animals be prevented access to the eagle fern by changing their pasture or removing the plants. Vitamin B1 and vitamin B6 were administered via feed as Ultra B® at 1 mL per 10 kg body weight per day for 2 days (providing 9 mg thiamine (vitamin B1) and 0.66 mg pyridoxine (vitamin B6) per kg body weight per day). Marked remission was observed, with 6 of 10 intoxicated animals with symptoms surviving (yielding a therapeutic success rate over 50%), but the therapy did not compensate for the loss of initial body condition. In total, of the 85 animals in the group after intoxication, 6 died, and 6 recovered. Conclusions The significance of this report lies in the scarcity of eagle fern intoxication cases reported in the literature, though such intoxication may become a significant problem as the development of outdoor rearing continues. Thus, eagle fern intoxication should be included in the differential diagnosis of nervous system symptoms in swine. The case also emphasizes the importance of anamnesis and discussion with the farmer as an essential step to guide diagnosis.

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“…The great eagle fern (Pteridium aquilinum) is an invasive plant that grows globally in very diverse environments, leading to it being di cult control in pastures [7]. Intoxication following ingestion is well documented in ruminants, including cattle, sheep and wild cervids [8,9]. In cattle, bracken fern ingestion causes enzootic haematuria, characterized by lower urinary tracts haemorrhages and neoplasms of epithelial and mesenchymal origins [9].…”

Section: Introductionmentioning

confidence: 99%

“…Intoxication following ingestion is well documented in ruminants, including cattle, sheep and wild cervids [8,9]. In cattle, bracken fern ingestion causes enzootic haematuria, characterized by lower urinary tracts haemorrhages and neoplasms of epithelial and mesenchymal origins [9]. Additionally, acute haemorrhagic syndrome, secondary to bone marrow aplasia and retinal atrophy have been documented in sheep [8], as has polioencephalomalacia [10].…”

Section: Introductionmentioning

confidence: 99%

Case of Eagle Fern (Pteridium Aquilinum) Poisoning on a Pig Farm

Waret-Szkuta

Jégou

Lucas

et al. 2020

Preprint

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Background: Free-range pig farming represents a minor proportion of pig production in France but attracts an increasing number of farmers because of societal expectations and the opportunity to use fodder consumed in the meadow. However, this type of farming faces several sanitary challenges, including biosecurity, parasitic management, and contact with wild fauna and pathogenic flora. Case presentation: Two Gascon pigs raised on an outdoor fattening farm in the Hautes-Pyrenees department of France were submitted after sudden death for necropsy at the National Veterinary School of Toulouse. The pigs were of two different breeds but from the same batch of 85 animals that had grazed on a 4-hectare plot of land being used for the first time. The combination of an in-depth interview with the breeder, the epidemiological information available, and the necropsy and histology examinations enabled the hypothesis of great eagle fern intoxication. Despite the small sample of animals available for diagnosis, the success of the administered therapy helped to confirm our diagnosis. In the short term, it was recommended that the animals be prevented access to the eagle fern by changing their pasture or by removing the plants. Vitamin B1 was administered in the feed in the amount of 1 mL per 10 kg body weight for two days (Ultra B®: 4.46 mg thiamine and 2.06 mg pyridoxine (vitamin B6) per kg body weight per day). A remarkable remission was observed, allowing 6 of 12 intoxicated animals with symptoms to survive (therapeutic success rate: 50%), but without compensating for the loss of the initial body condition. In total, out of the 85 animals in the batch after this intoxication, 6 animals died and 6 recovered.Conclusion: The interest of this report lies in the scarcity of eagle fern intoxication cases reported in the literature, although it may become a significant problem along with the development of outdoor rearing. In this context, it should be included in the differential diagnosis of nervous system symptoms in swine. The case also underlines the importance of anamnesis and discussions with the farmer to guide the diagnosis and reminds us that this step is essential in the clinical process.

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HEMATURIA AND URINARY BLADDER LESIONS COMPATIBLE WITH BRACKEN FERN (PTERIDIUM AQUILINUM) INTOXICATION IN CAPTIVE FALLOW DEER (DAMA DAMA)

Cited by 14 publications

References 15 publications

Ptaquiloside, the Major Carcinogen of Bracken Fern, in the Pooled Raw Milk of Healthy Sheep and Goats: An Underestimated, Global Concern of Food Safety

Ptaquiloside, the Major Carcinogen of Bracken Fern, in the Pooled Raw Milk of Healthy Sheep and Goats: An Underestimated, Global Concern of Food Safety

A case of eagle fern (Pteridium aquilinum) poisoning on a pig farm

Case of Eagle Fern (Pteridium Aquilinum) Poisoning on a Pig Farm

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