Hematuria From Sulfathiazole Therapy in Pneumonia

Arnett, John H.

doi:10.1001/jama.1940.72810310003007a

Cited by 16 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neither sulfanilamide nor sulfapyridine had this effect. In no case did gross or microscopic hematuria or pain, as reported by Arnett,8 give any…”

Section: Comparison Of Results With Sulfapyridine and Sulfathiazolementioning

confidence: 78%

The Treatment of Pneumococcal Pneumonia

Janeway¹,

Beeson²

1941

N Engl J Med

View full text Add to dashboard Cite

risky procedure. I do not dare to look up how much of the free-bed money for diabetic patients in the New England Deaconess Hospital is spent on neglected toes, but I venture to say that the charity money devoted to the toes of elderly patients is five times that expended on diabetic patients in their teens. Consider the difference in the efficiency and expectation of life of the two groups.A defeatist policy will never win a diabetic war.Always attack diabetes aggressively the more aggression, the younger the diabetic and the more recent the onset of the disease. Best2 has shown that diabetes can be prevented in a dog following the injection of anterior pituitary extract, provided insulin is simultaneously administered. Indeed, if a dog is fasting it is impossible to give it diabetes by the injection of anterior pituitary extract. Lukens3 has shown in a cat that even after two months the diabetes definitely produced by injections of anterior pituitary extract can be cured by energetic treatment with insulin. In the cat, for some months following the development of the disease, the islands of Langerhans in the pancreas are in the stage of hydropic degeneration, and in that stage the lesions are reversible and the diabetes can be cured.How thankful I am that the words "prevention" and "cure" have now entered the vocabulary associated with diabetes, even though they apply alone to experimental diabetes in an animal. There is no question in my mind that some of those who hear me today will live to see the extension of these experiments to diabetes in man.

show abstract

“…Neither sulfanilamide nor sulfapyridine had this effect. In no case did gross or microscopic hematuria or pain, as reported by Arnett,8 give any…”

Section: Comparison Of Results With Sulfapyridine and Sulfathiazolementioning

confidence: 78%

The Treatment of Pneumococcal Pneumonia

Janeway¹,

Beeson²

1941

N Engl J Med

View full text Add to dashboard Cite

show abstract

“…Arnett,47 to be sure, reported a toxic renal effect on a 72 year old woman who had received a total dose of only 14 Gm. An analysis of the dosage shows that our patient had received a total of 8 Gm.…”

Section: Autopsy Observations (Case I)mentioning

confidence: 99%

Severe Forms of Chickenpox in Adults

Waring¹

1942

Arch Intern Med (Chic)

View full text Add to dashboard Cite

Sulfathiazole for Treatment of Staphylococcic Meningitis

Cohen¹,

Galpern²

1941

Archives of Otolaryngology - Head and Neck Surgery

View full text Add to dashboard Cite

Sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole), the newest of the sulfanilamide group of drugs, is ready to take its place in the armamentarium of chemotherapy. Sulfathiazole therapy has progressed so rapidly since the release of the drug that the literature associated with it is poorly organized. Our interest in the drug was stimulated by what impressed us as an almost unbelievable therapeutic result in what we had feared was an incurable condition. The report of this case follows. We feel that a preliminary review of the literature concerning sulfathiazole is worth while at this time.Sulfathiazole is the thiazole analogue of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and was first reported by Forsbinder and Walter 1 and by Lott and Bergeim.2 These authors described the methods of preparation and their experiments with these drugs against streptococcic and pneumococcic infections in mice. The original work on the physical and chemical characteristics of sulfathiazole and its salt was done at that time, and the tests for the estimation of the drug in the blood were described.Van Dyke 3 and his co-workers showed the rapid metabolism of this drug in the body. Sulfathiazole was proved to be more rapidly absorbed than the other sulfanilamide derivatives, the blood concentration reaching its highest level in one to three hours after ingestion. Further, it dis-

show abstract

Hematuria From Sulfathiazole Therapy in Pneumonia

Cited by 16 publications

References 4 publications

The Treatment of Pneumococcal Pneumonia

The Treatment of Pneumococcal Pneumonia

Severe Forms of Chickenpox in Adults

Sulfathiazole for Treatment of Staphylococcic Meningitis

Contact Info

Product

Resources

About