Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas

Yang, Xu; Li, Jun; Wang, Shaohong; Xu, Li; Shi, Ke; Ding, Xuemei; Sun, Wenbing; Gao, Jun

doi:10.1097/meg.0000000000001636

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Mild cases of SIR syndrome are mainly manifested as fever, tachycardia, and tachypnea, whereas severe cases often lead to multiple organ dysfunctions (8). According to experimental study (15), damage to RBCs caused by RFA not only leads to hemoglobinuria but also releases heme to the peripheral circulation, which induced the production of inflammatory factors that contribute to SIR syndrome. So, recognition of hemolytic processes during this treatment will likely serve as a foundation for developing new approaches, to diminish or neutralize the effects of the extracellular Hb and heme.…”

Section: Discussionmentioning

confidence: 99%

Complications of Radiofrequency Ablation for Hepatic Hemangioma: A Multicenter Retrospective Analysis on 291 Cases

Gao

Yin

et al. 2021

Front. Oncol.

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PurposeTo report the complications of radiofrequency ablation (RFA) for hepatic hemangioma.Patients and MethodsInvestigators from six centers performed RFA for hepatic hemangioma and used a standardized follow-up protocol. Data were collected from 291 patients, including 253 patients with hepatic hemangioma 5 to 9.9 cm in diameter (group A) and 38 with hepatic hemangioma ≥ 10 cm (group B). Technical success, complete ablation, and complications attributed to the RFA procedure were reported. Analysis of variance was used to determine whether the major complication rate was related to tumor size or clinical experience.ResultsA total of 304 lesions were treated in 291 patients. Technical success was achieved without adverse events in all cases. A total of 301 lesions were completely ablated, including 265 of 265 (100%) lesions in group A, and 36 of 39 (92.31%) in group B. The rate of technology-related complications was similar in groups A and B (5.14% (13/253) and 13.16% (5/38), respectively; P = 0.121). Moreover, all technology-related complications occurred during the early learning curve period. The rate of hemolysis-related complications in two groups were 83.40% (211/253) and 100% (38/38) (P =0.007) and the systemic inflammatory response syndrome-related complications in two groups were 33.99% (86/253) and 86.84% (33/38) (P<0.001). There were no delayed complications in either group.ConclusionRFA is minimally invasive, safe, and effective for hepatic hemangiomas 5 to 9.9 cm in diameter. More clinical data are needed to confirm the safety of RFA for hepatic hemangiomas ≥ 10 cm.

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Section: Discussionmentioning

confidence: 99%

Complications of Radiofrequency Ablation for Hepatic Hemangioma: A Multicenter Retrospective Analysis on 291 Cases

Gao

Yin

et al. 2021

Front. Oncol.

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“…Previous study has found that HMGB1 is closely related to the pyroptosis of vascular cells ( 14 ). Through subablative hypertherapy of HUVECs, HMGB1 induced the pyroptosis of HUVECs, while the addition of HMGB1 inhibitor ethyl pyruvate significantly reduced the pyroptosis of HUVECs ( 15 ). In this study, it was also found that pyroptosis markers significantly increased in the peripheral blood of SV patients, which were positively correlated with HMGB1 expression, indicating whether HMGB1 can mediate the occurrence and development of diseases through the activation of pyroptosis.…”

Section: Discussionmentioning

confidence: 99%

The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and its Relation with Systemic Vasculitis Patients

Qin,

Li,

Shi

et al. 2023

ijph

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Background: We aimed to explore the expression of high mobility group box-1 (HMG1) in the peripheral blood of systemic vasculitis (SV) patients. Methods: The peripheral blood were collected from 35 healthy controls and 35 SV patients, and the expressions of HMGB1 and pyroptosis-related markers in the samples were detected by ELISA. They were admitted to the Department of Rheumatology and Immunology of the Third Affiliated Hospital of Qiqihar Medical University, China in 2022. The severity of diseases was graded according to the diagnosis and treatment norms of SV. The correlation between HMGB1 expression level and disease-related indicators and grades were explored through Pearson correlation analysis. The specific mechanism of HMGB1 mediating the occurrence and development of diseases through the regulation of endothelial pyroptosis was clarified. Results: HMGB1 expression significantly increased in the peripheral blood of SV patients compared with healthy controls (P<0.0001). Pearson correlation analysis indicated that HMGB1 expression level in serum gradually increased with the aggravation in SV patients. The expression levels of ASC (P<0.0001), IL-1β (P=0.004) and IL-18 (P<0.0001) in peripheral blood of SV patients were significantly increased, which were significantly positively correlated with HMGB1 in peripheral blood (P<0.0001). Recombinant HMGB1 significantly promoted the expression of ASC, IL-1β and IL-18 in vascular endothelial cells. Recombinant HMGB1 stimulation significantly activated NLRP3 inflammasome, and the additional addition of NLRP3 inhibitor significantly inhibited HMGB1-mediated endothelial pyroptosis. Conclusion: HMGB1 expression was significantly high in the peripheral blood of SV patients, which was positively correlated with the severity of diseases. HMGB1 could mediate pyroptosis through activating TLR4/NF-κB/NLRP3 signaling pathway.

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“…Some studies have shown that hyperlipidaemia can reduce fibrinolytic function and increase coagulation activity in the patient. The reason for this is that free fatty acids in hyperlipidaemic patients can provide activated contact surfaces,[ 31 , 32 ] increase the charge density on the surface of large particle lipoproteins and promote the activation of plasma coagulation factor VII, which ultimately aggravates blood coagulation. [ 33 , 34 ] The preoperative LDL-C level influences blood hypercoagulability because oxidised LDL can affect the synthesis of nitric oxide and the activity of thrombin-regulated proteins and impair the endothelial function of blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for hypercoagulability after laparoscopic hepatic haemangioma resection

Mei

Shi

Cheng

et al. 2022

Journal of Minimal Access Surgery

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Background: Laparoscopic hepatectomy with a small incision, light abdominal wall trauma and rapid postoperative recovery has been widely used in the surgical treatment of benign liver diseases. However, the occurrence of complications, such as deep-vein thrombosis, associated with laparoscopic techniques has raised concerns. This study aimed to investigate the factors influencing the development of a hypercoagulable state in patients following laparoscopic hepatic haemangioma resection. Materials and Methods: Between 2017 and 2019, 78 patients to be treated by laparoscopic hepatic haemangioma resection were selected prospectively for the study. The differences in relevant clinical factors between patients with and without blood hypercoagulability at 24 h after surgery were compared, and the factors influencing the development of blood hypercoagulability after surgery were analysed. Results: The study included 78 patients, split into the hypercoagulable group ( n = 27) and nonhypercoagulable group ( n = 51). Compared with patients who did not develop blood hypercoagulability, patients who did had significantly higher preoperative levels of fibrinogen (Fib), D-dimer (D-Di), fibrinogen degradation products (FDP), platelet count (PLT), low-density lipoprotein cholesterol (LDL-C) and history of hyperlipidaemia whereas high-density lipoprotein cholesterol (HDL-C) levels were significantly lower ( P < 0.05.) in hypercoagulable group. Univariate and multifactorial logistic regression analyses showed that a history of hyperlipidaemia, Fib ≥3.83 g/L, D-Di ≥9.12 μg/ml, FDP ≥14.64 μg/ml, PLT ≥292 × 10 9 /L, HDL-C ≥1.25 mmol/L and LDL-C ≥2.03 mmol/L was the most common independent risk factors for the development of a hypercoagulable state of blood in patients after laparoscopic hepatic haemangioma resection ( P < 0.05). Conclusion: For patients undergoing laparoscopic hepatic haemangioma resection, attention should be paid to the development of a hypercoagulable state in those with the risk factors described in this study.

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Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas

Cited by 10 publications

References 25 publications

Complications of Radiofrequency Ablation for Hepatic Hemangioma: A Multicenter Retrospective Analysis on 291 Cases

Complications of Radiofrequency Ablation for Hepatic Hemangioma: A Multicenter Retrospective Analysis on 291 Cases

The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and its Relation with Systemic Vasculitis Patients

Risk factors for hypercoagulability after laparoscopic hepatic haemangioma resection

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