Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration

Bae, Gi‐Sang; Kim, Dong-Goo; Jo, Il‐Joo; Choi, Sun-Bok; Kim, Myoung-Jin; Shin, Joon Yeon; Kim, Donguk; Song, Ho‐Joon; Joo, Myungsoo; Park, Sung‐Joo

doi:10.1016/j.intimp.2019.01.051

Cited by 14 publications

(6 citation statements)

References 44 publications

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“…CXCL16 contributed to the development of acinar cell necrosis through the induction of CCL9 and subsequent neutrophil infiltration (Sakuma et al., 2018 ). The recent study verified that HO-1 could suppress neutrophil infiltration in inflamed pancreas via CXCL2 inhibition (Bae et al., 2019 ). This evidence represented the crucial role of chemokines in the inflammatory cells trafficking.…”

Section: Molecular and Cellular Mechanisms Of Acute Pancreatitismentioning

confidence: 75%

“…For example, Chaiqin Chengdi Decoction has been reported to significantly improve the intestinal paralysis in clinic, which could effectively promote the gastrointestinal motility and benefit the recovery of gastrointestinal function in patients with acute pancreatitis (Pan et al., 2017 ). Another study demonstrated that Chaiqin Chendi Decoction could upregulate the expression of endoplasmic reticulum Ca 2+ -ATPase in pancreatic tissues, reduce intracellular calcium overload and relieve pancreatic tissue lesions (Bae et al., 2019 ). Clinical study also indicated that Chaiqin Chendi Decoction serum notably decreased matrix metalloproteinase nine (MMP 9) level in patients with SAP (Guo et al., 2013 ), while MMP 9 was positively correlated with the pathological score.…”

Section: Therapeutic Drugs For Acute Pancreatitismentioning

confidence: 99%

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Drug discovery and formulation development for acute pancreatitis

et al. 2020

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Acute pancreatitis is a sudden inflammation and only last for a short time, but might lead to a life-threatening emergency. Traditional drug therapy is an essential supportive method for acute pancreatitis treatment, yet, failed to achieve satisfactory therapeutic outcomes. To date, it is still challenging to develop therapeutic medicine to redress the intricate microenvironment promptly in the inflamed pancreas, and more importantly, avoid multi-organ failure. The understanding of the acute pancreatitis, including the causes, mechanism, and severity judgment, could help the scientists bring up more effective intervention and treatment strategies. New formulation approaches have been investigated to precisely deliver therapeutics to inflammatory lesions in the pancreas, and some even could directly attenuate the pancreatic damages. In this review, we will briefly introduce the involved pathogenesis and underlying mechanisms of acute pancreatitis, as well as the traditional Chinese medicine and the new drug option. Most of all, we will summarize the drug delivery strategies to reduce inflammation and potentially prevent the further development of pancreatitis, with an emphasis on the bifunctional nanoparticles that act as both drug delivery carriers and therapeutics.

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Section: Molecular and Cellular Mechanisms Of Acute Pancreatitismentioning

confidence: 75%

Section: Therapeutic Drugs For Acute Pancreatitismentioning

confidence: 99%

Drug discovery and formulation development for acute pancreatitis

et al. 2020

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“…Similarly, myeloid HO-1 conferred protection against renal IR injury, and injection of hemin prior to surgery offered IR injury resistance in mice [66]. In a murine pancreas model, upregulation of HO-1 was also found to reduce neutrophil infiltration and lessen the severity of acute pancreatitis [67]. Other studied have found that HO-1 causes immature dendritic cells to differentiate into tolerogenic dendritic cells (DCs) [68].…”

Section: Heme Oxygenase-1mentioning

confidence: 99%

Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs

Soo

Welch

Marsh

et al. 2020

Transplantation Reviews

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“…Among the sesquiterpenes ( Figure 29 ), deoxonarchinol A isolated from Nardostachys jatamansi is an effective inducer of HO-1, which regulates neutrophil infiltration in acute pancreatitis by inhibiting chemokine ligand 2 [ 263 ]. Anti-neuroinflammatory effects through positive regulation of NRF2/HO-1 signaling by deoxonarchinol A together with narchinol B have also been investigated [ 264 ].…”

Section: Role Of Michael Acceptorsmentioning

confidence: 99%

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

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The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.

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Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration

Cited by 14 publications

References 44 publications

Drug discovery and formulation development for acute pancreatitis

Drug discovery and formulation development for acute pancreatitis

Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

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