Heme-oxygenase 2 (HO-2) distribution in anorectum of opossum: Colocalization with neuronal nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP)

Battish, Raman; Cao, Gaoyuan; Lynn, Richard B.; Chakder, Sushanta; Rattan, Satish

doi:10.1016/s0016-5085(98)82951-x

Cited by 3 publications

(2 citation statements)

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“…The studies further demonstrated nNOS‐immunoreactive (IR) 60 (nNOS‐IR) neurones in the myenteric plexi 61,62 . nNOS‐ and VIP‐immunoreactivity (VIP‐IR) was co‐localized in the IAS myenteric plexi and nerve terminals of humans and animals 60,63,64 . The studies provided direct evidence for the conservation of l ‐arginine to NO by the recycling of l ‐citrulline 65 .…”

Section: Multiplicity Of Inhibitory Neurotransmissionmentioning

confidence: 81%

The internal anal sphincter: regulation of smooth muscle tone and relaxation

Rattan

2005

Neurogastroenterology Motil

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105

108

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Basal tone in the internal anal sphincter (IAS) is primarily myogenic. Neurohumoral substances like angiotensin II may partially provide external signal for the basal tone in the IAS. The sphincteric relaxation on the contrary is neurogenic by activation of non-adrenergic non-cholinergic (NANC) nerves that release nitric oxide (NO), vasoactive intestinal polypeptide (VIP) and perhaps carbon monoxide. Because of the presence of spontaneous tone, the IAS offers an excellent model to investigate the nature of the inhibitory neurotransmission for NANC relaxation. Work from different laboratories in different species concludes that NO is the major contributor in the NANC relaxation. This may invoke the role of other inhibitory neurotransmitters such as VIP, working partly via NO. An understanding of the basic regulation of basal tone in the IAS and nature of inhibitory neurotransmission are critical in the pathophysiology and therapeutic potentials in the anorectal motility disorders.

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Section: Multiplicity Of Inhibitory Neurotransmissionmentioning

confidence: 81%

The internal anal sphincter: regulation of smooth muscle tone and relaxation

Rattan

2005

Neurogastroenterology Motil

Self Cite

105

108

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“…What therefore is the role of CO in neural activity? Two independent research groups have found that CO is linked to the functions of nonadrenergic, noncholinergic neurons of the enteric nervous system and, therefore, has an impact on spontaneous slow waves of the smooth muscle [ 92 , 93 ]. Furthermore, it has been reported that CO may influence long-term potentiation (LTP) in a tonic manner [ 94 ]; through the strengthening of synapses, LTP has been shown to be involved in learning and memory.…”

Section: Effect Of Corms In Neuroprotection and Neuronal Differentmentioning

confidence: 99%

An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules

Ismailova

Kuter

Bohle

et al. 2018

Bioinorganic Chemistry and Applications

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Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called “carbon monoxide releasing molecules (CORMs).” This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs.

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Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX

Rattan

Fan

Chakder

1999

American Journal of Physiology-Gastrointestinal and Liver Physi

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The putative heme oxygenase inhibitor zinc protoporphyrin IX (ZnPP IX) is known to exert diverse actions, including inhibitory action on smooth muscle relaxation by vasoactive intestinal polypeptide (VIP). The studies were performed in the opossum lower esophageal sphincter (LES) smooth muscle to determine the site of the inhibitory action of ZnPP IX in the smooth muscle relaxation by VIP. We also examined the effect of a direct Gs protein activator, cholera toxin (CTX), known to stimulate adenylate cyclase (AC). CTX caused relaxation of the LES smooth muscle by its action directly at the smooth muscle cells. The convergence of the common mechanisms of actions of VIP and CTX on AC was determined by the suppression of their effects by the AC inhibitor and CTX desensitization. ZnPP IX caused attenuation of the LES smooth muscle relaxation by VIP but not by CTX. ZnPP IX but not zinc deuteroporphyrin IX caused significant inhibition of VIP binding to the membrane receptor. We conclude that ZnPP IX attenuates VIP-induced LES smooth muscle relaxation by inhibition of VIP binding to G protein-coupled receptors linked to AC at a point proximal to G protein activation.

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Heme-oxygenase 2 (HO-2) distribution in anorectum of opossum: Colocalization with neuronal nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP)

Cited by 3 publications

References 0 publications

The internal anal sphincter: regulation of smooth muscle tone and relaxation

The internal anal sphincter: regulation of smooth muscle tone and relaxation

An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules

Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX

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