Heme Proteins, Heme Oxygenase-1 and Oxidative Stress

Morimatsu, Hiroshi; Takahashi, Toru; Shimizu, Hiroko; Matsumi, Junya; Kosaka, Junko; Morita, Kiyoshi

doi:10.5772/33757

Cited by 5 publications

(2 citation statements)

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“…The heme is held between two of these helices (Figure 3b). HO-1 acts as a cytoprotective stress protein and provides defense against oxidative stress associated with sickle cell disease by accelerating the degradation of pro-oxidant heme and hemo proteins to the radical scavenging bile pigments, biliverdin, and bilirubin [65]. HO-1 helps the body's defense in response to physical stress.…”

Section: Heme Oxygenasementioning

confidence: 99%

See 1 more Smart Citation

Phytotherapy and the Relevance of Some Endogenous Antioxidant Enzymes in Management of Sickle Cell Diseases

Afolabi¹,

Osikoya²,

Okafor³

2016

Sickle Cell Disease - Pain and Common Chronic Complications

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Introduction: Sickle cell disease (SCD) is one of the most devastating diseases ravaging most populations. Methodology, results, and discussion: The numerous plants earlier reported to be used for treating SCD were compiled along with their geographical locations (using relevant online databases when not provided in cited articles for each plant) and relative antisickling strength. The process of hemolysis in sickle cell diseases, a brief overview of the current treatments, and management of sickle cell diseases is considered in the chapter. The activities of endogenous antioxidants and some biochemical enzyme markers coupled to these plants' ability to maintain the integrity of red blood cell membrane are discussed in line with their antisickling health benefits and are also used to proffer more reliable molecular therapeutic strategies for managing sickle cell diseases. Furthermore, the operational principles of some enzymes, as well as their contributions to advancement of knowledge for management of the disease, were examined. Conclusion: Geographical spread of these identified antisickling plants contributes to low levels of sickle cell patients where the potentials are known. More efforts should therefore be channeled toward increasing awareness about the plants, as well as harnessing their active principles to obtain a more lasting solution to sickle cell disease at the molecular level.

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Section: Heme Oxygenasementioning

confidence: 99%

“…HO-1 helps the body's defense in response to physical stress. The levels of heme are strictly controlled by the balance between heme biosynthesis and catabolism as indicated in Figure 4 [65]. The key factor in the transcriptional activation of HO-1 is transcription factor Nrf2 (Figure 4).…”

Section: Heme Oxygenasementioning

confidence: 99%