Heme synthetase in Trypanosoma cruzi

Salzman, Teresa A.; Batlle, Alcira

doi:10.1016/0305-0491(86)90043-x

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Ho-1 In Chagas Disease1

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2020

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“…Since heme is an indispensable molecule for T . cruzi biology [ 86 , 87 ], the biosynthetic pathway is absent in this parasite [ 88 ], and it is possible that increased HO-1 expression and consequent reduction of the intracellular heme pool is detrimental to the parasite. Reductions in the pool of intracellular labile iron are also detrimental to the parasite.…”

Section: Ho-1 In Chagas Diseasementioning

confidence: 99%

Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

et al. 2020

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Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.

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Section: Ho-1 In Chagas Diseasementioning

confidence: 99%