Hemichondrodiastasis for the Treatment of Genu Varum Deformity Associated With Bone Dysplasias

Givon, Uri; Schindler, Amos; Ganel, A

doi:10.1097/01241398-200103000-00022

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Distraction epiphysiolysis seems quite sensitive to experimental variables, and it is difficult to achieve reproducible results. Continued growth may be possible after removal of the distraction force 29,34 if the fracture does not completely destroy the capacity of physeal chondrocytes to proliferate.…”

Section: Discussionmentioning

confidence: 99%

Chondrocyte injection in distraction epiphysiolysis (rabbit model)

Ahn

Erdin

Smith

et al. 2005

Journal Orthopaedic Research

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The purpose of this study was to determine if cultured chondrocytes could prevent premature closure of the physis after physeal distraction in a rabbit model. Epiphyseal distraction at the proximal tibial epiphysis was performed in 24 immature rabbits. Chondrocytes were harvested from the iliac apophysis. The animals were divided into three groups: A, epiphyseal distraction alone; B, injection of phosphate buffered saline (PBS) after epiphyseal distraction; and C, injection of cultured chondrocytes after epiphyseal distraction. After epiphyseal separation was noted radiographically, each animal was evaluated at routine intervals. At 2 to 4 weeks, significant tibial lengthening as compared to the contralateral tibia was noted in all three groups. At 10 weeks, lengthening was apparent only in group C; in groups A and B, the operated tibia was shorter than the unoperated one. Histologic examination at 4 weeks revealed partial bony bridge formation with cell clustering in the fibrocartilaginous matrix in groups A and B. In group C , the matrix showed a typical hyaline aspect with cells organized in columns at the injection site. The zone of hypertrophic chondrocytes was enlarged. It appears that the injected cells differentiated into hypertrophic chondrocytes and delayed premature physeal closure. At 10 weeks after distraction of the physis, the width of the physis was restored to 75% of normal, but disordered chondrocyte growth with cell clustering was present in the cell-injected group. ß

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Section: Discussionmentioning

confidence: 99%

Chondrocyte injection in distraction epiphysiolysis (rabbit model)

Ahn

Erdin

Smith

et al. 2005

Journal Orthopaedic Research

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show abstract

“…47 Meanwhile, Zarzycki et al reported no instances of premature cartilage fusion in their studies of 40 physeal distraction procedures, 45 and Givon reported three cases of successful bilateral proximal tibial hemichondrodiastasis in patients between the ages of 3 and 7. 48 De Bastiani discussed that in children who underwent limb elongation at younger than 10 years old, the lengthened limb grew at a slower rate than the normal limb, suggesting that the issue may not be premature growth plate fusion but instead reduced growth plate function. 49 Because of this, most authors suggest reserving chondrodiastasis for adolescents approaching skeletal maturity who have a highly predictable limb length discrepancy.…”

Section: Chondrodiastasismentioning

confidence: 99%