Hemichorea Associated with Nonketotic Hyperglycemia: Clinical and Neuroimaging Features in 12 Patients

Guo, Yan; Miao, Yanwei; Ji, Xiaofei; Li, Ming; Li, Xuan; Sun, Xuejun

doi:10.1159/000357210

Cited by 22 publications

(44 citation statements)

References 32 publications

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“…Chorea/ballism associated with hyperglycemia was first described by Bedwell in 1960, 3 but fewer than 200 cases and very few case series have been published since. 4,5 The typical triad includes unilateral (or bilateral) involuntary movements, contralateral (or bilateral) striatal abnormalities on neuroimaging, and hyperglycemia in patients with known or previously unrecognized diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Hemichorea/Hemiballism Associated with Hyperglycemia: Report of 20 Cases

Cosentino

Torres

Nuñez

et al. 2016

Tremor and Other Hyperkinetic Movements

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Background: Hemichorea/hemiballism associated with nonketotic hyperglycemia is a well-recognized syndrome, but few case series have been reported in the literature. Case Report: We describe 20 patients with hemichorea/hemiballism associated with hyperglycemia (9 males and 11 females) with mean age of 67.8 years. Ten patients had a previous diagnosis of type 2 diabetes mellitus, and one had type 1 diabetes mellitus. Six of them had documentation of poor diabetic control over at least the last 3 months. Nine patients had new-onset hyperglycemia with a diagnosis of diabetes mellitus made after discharge. Seventeen patients had unilateral chorea/ballism, while three had bilateral chorea/ballism. Eighteen cases had striatal hyperdensities on computed tomography (CT) and/or hyperintense signals on magnetic resonance imaging (MRI). The putamen was affected in all cases, and the caudate nucleus was involved in nine. Discussion: Hemichorea/hemiballism associated with nonketotic hyperglycemia can be the presenting sign of diabetes mellitus in almost half of cases or can occur after a few months of poor glycemic control in patients with diagnosed diabetes. This case series is one of the largest to date and adds valuable information about clinical and neuroimaging features that are comparable with published data but also emphasize the role of adequate diabetes mellitus control.

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Section: Discussionmentioning

confidence: 99%

Hemichorea/Hemiballism Associated with Hyperglycemia: Report of 20 Cases

Cosentino

Torres

Nuñez

et al. 2016

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

show abstract

“…Chorea/ballism associated with hyperglycemia was first described by Bedwell in 1960, 3 but fewer than 200 cases and very few case series have been published since. 4 , 5 The typical triad includes unilateral (or bilateral) involuntary movements, contralateral (or bilateral) striatal abnormalities on neuroimaging, and hyperglycemia in patients with known or previously unrecognized diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Hemichorea/Hemiballism Associated with Hyperglycemia: Report of 20 Cases

Cosentino,

Torres,

Nuñez

et al. 2016

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

“…Hemichorea-hemiballismus may result from a vascular, autoimmune, infective, metabolic, or neurodegenerative pathology involving the basal ganglia. 5 HNKH has been associated with poor glycemic control in diabetic patients. Nearly one-third (30.9%) of cases developed choreo-ballistic movements as an initial manifestation of DM.…”

Section: Jmdmentioning

confidence: 99%