Hemicyanine‐Based Highly Water‐Soluble Probe for Extracellular Nitroreductase
Shaoli Jiang,
Le Xu,
Yihong Zhong
et al.
Abstract:Nitroreductase (NTR) has long been a target of interest for its important role involved in the nitro compounds metabolism. Various probes have been reported for NTR analysis, but rarely able to distinguish the extracellular NTR from intracellular ones. Herein we reported a new NTR sensor, HCyS‐NO2, which was a hemicyanine molecule with one nitro and two sulfo groups attached. The nitro group acted as the reporting group to respond NTR reduction. Direct linkage of nitro group into the hemicyanine π conjugate sy… Show more
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