Hemifacial Microsomia: A Mini Review

Sharma, Shilpa Ashok; Patil, Sayali Vikram Pagar; Mudhol, Anupama; Shashidhar, Jyothi

doi:10.9734/jammr/2019/v30i730208

Cited by 1 publication

(2 citation statements)

References 27 publications

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“…It has various clinical manifestations and can occur alone or as a symptom of a syndrome. 14 A more complete understanding of the development of the outer ear structure is necessary for elucidation of the mechanisms underlying congenital ear malformation. 15 Ear cartilage is the main structure of the auricle and aberrant chondrogenesis is thought to play a role in microtia.…”

Section: Discussionmentioning

confidence: 99%

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Changes in the Transcriptome and Proteome of Cartilage in Microtia

Dong

Jiang²,

Ling³

et al. 2021

Journal of Craniofacial Surgery

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Congenital microtia is a severe physiological defect and is among the most common craniofacial defects. It is characterized by severe auricle dysplasia, external auditory canal atresia or stenosis, and middle ear malformation, though inner ear development is mostly normal with some hearing occurring through bone conduction. Auricular reconstruction is the only treatment for congenital microtia. In this study, the authors integrated messenger ribonucleic acid and mass spectrometry data of cartilage obtained from the affected and unaffected sides of 16 unilateral microtia patients who had undergone ear reconstruction surgery. The authors next performed functional analyses to investigate differences in the proteome of the affected and unaffected ears to elicit molecular pathways involved in microtia pathogenesis. The authors collected 16 pairs samples. Proteomic and transcriptomic analyses identified 47 genes that were differentially expressed in affected and unaffected cartilage. Integrated pathway analysis implicated the involvement of genes related to cell adhesion, extracellular matrix organization, and cell migration in disease progression. Through the integration of gene and protein expression data in human primary chondrocytes, the authors identified molecular markers of microtia progression that were replicated across independent datasets and that have translational potential.

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Section: Discussionmentioning

confidence: 99%

“…Microtia is one of the most important birth defects in the maxillofacial region. It has various clinical manifestations and can occur alone or as a symptom of a syndrome 14 . A more complete understanding of the development of the outer ear structure is necessary for elucidation of the mechanisms underlying congenital ear malformation 15 .…”

Section: Discussionmentioning

confidence: 99%