Hemiplegic (unilateral) cerebral palsy in northern Stockholm: clinical assessment, brain imaging, EEG, epilepsy and aetiologic background factors

Tillberg, Elsa; Isberg, Bengt; Persson, Jonas

doi:10.1186/s12887-020-1955-z

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Moreover, the frequency of epilepsy was greater in the group of subjects suffering from spastic quadriplegia, and with higher motor dysfunction, as reported in the literature [16]. In the present cases, the types of epilepsy most frequently observed in CP children were focal-generalized (37%), epileptic encephalopathy (15%), and seizures with neonatal onset (33%), which were mainly found in children with spastic quadriplegia, focal in the study of Tillberg et al [4]. Epilepsy in CP is related to underlying brain lesions and can be classified according to the anatomical site of the brain lesion; namely, the cerebral cortex, pyramidal tract, extrapyramidal systems, or cerebellum [11].…”

Section: Discussionsupporting

confidence: 80%

“…The significance of epilepsy in individuals with CP is discussed controversially in the literature. Epilepsy is common in cerebral palsy, present in 30%–40% of cases [ 4 , 16 ], and seizures are reported on 35.5% of CP children in the hemiplegia subgroup [ 15 ]. In the 93 children analyzed in the present study, the incidence of epilepsy was calculated to be 49%, on average higher than that reported in the literature [ 16 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on international consensus, a generally agreed upon definition of CP is as follows: CP describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain [1,2]. The motor disorders of CP are often associated with a wide and complex group of disturbances, such as sensation, perception, cognition, communication, and behavior disturbances, as well epilepsy and secondary musculoskeletal problems [3][4][5]. The complex manifestations of the disorder led to an extension of the term CP to cerebral palsy spectrum disorder.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

et al. 2020

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Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had comorbid epilepsy. The aim of this study was to report our experience of analyzing, in particular, (a) some of the clinical aspects of the different type of CP, and (b) the relationship between the clinical data of children affected by CP plus epilepsy and each type of CP. Methods: This retrospective single-center study was performed with 93 children admitted to the Pediatric Department of the University of Catania, Italy, affected by CP and distinguished according to the type of motor clinical presentation, with 46 showing epileptic seizures, compared to a control group of 136 children affected by epilepsy without other neurologic disorders. Results: Among the 93 CP children, 25 (27%) had spastic quadriplegia (plus one patient with dystonic quadriplegia), 39 (42%) had spastic hemiplegia, 11 (12%) had spastic diplegia (plus two with ataxia and one with dyskinetic CP), and 14 (15%) did not have a well-defined type of CP. The frequency of epilepsy was higher in affected CP children who showed major motor dysfunction (GMFCS IV–V types). As regards the 46 children with CP plus epilepsy, compared to the group of the control, the age of epilepsy onset was found to be statistically significant: 21 ± 35.1 months vs. 67 ± 39.7. Conclusions: Epilepsy represents one of the most frequent comorbidities of cerebral palsy. In children with CP, particular attention should be paid to the early identification and treatment of comorbid epilepsy.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

et al. 2020

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“…In the current case, the sorts of seizures most as often as possible seen in CP children were generalized tonic-clonic with spastic quadriplegia (Tillberg et al, 2020). Neonatal seizures can be a solid indicator of seizures in CP (El-Tallawy et al, 2014).…”

Section: Ofmentioning

confidence: 65%

A unique case report of microcephaly and malnutrition in a child with spastic quadriplegic cerebral palsy

Mishra¹,

Varma²,

Varma³

et al. 2022

disssi

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“…This difference may depend on case selection, where the frequency of epilepsy is greater in the group of CP subjects with spastic quadriplegic type, and with more severe motor dysfunction, as reported in the literature, which may be a reflection of the severity of damage to the brain. (20)(21)(22) The prevalence of vitamin D deficiency in children with cerebral palsy varies throughout the world. In this study, of 85 children with cerebral palsy, 54.1% had deficiency, and 29.4% had vitamin D insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Vitamin D Status of Cerebral Palsy Children at Haji Adam Malik Hospital Medan

Yusnita,

H.Saing,

Buana Nasution

2024

IJRP

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Cerebral palsy (CP) is a disorder of motor function and posture, due to impaired brain development. Children with CP are at risk of experiencing vitamin D deficiency due to reduced mobility, low vitamin D intake, and use of anti-epileptic drugs. Vitamin D deficiency can cause hypocalcemia and reduce bone mineral density, osteopenia, and rickets so that it can result in pathological fractures even with only minor injuries. Monitoring vitamin D levels, early identification, and appropriate vitamin D supplementation are important in reducing the risk of injury and fracture in PS children. This study aims to determine the clinical profile of children with cerebral palsy and their vitamin D status. Methods: A descriptive study of children with cerebral palsy aged 2 to 6 years at the Neuro-pediatric outpatient clinic at H. Adam Malik Hospital, Medan from November 2022 to April 2023. Primary data was obtained from interviews and examination of serum vitamin D levels. Secondary data was obtained from medical records. Results: Eighty-five CP children were included in this study, 51.8% were boys and 48.2% were girls. The mean age of the subjects was 3.48 years, 34.1% of the subjects experienced malnutrition. The etiology of CP mainly occurs in the perinatal period (66.7%). Most subjects had spastic type (75.3%), with GMFCS grade V being the most common type (34.1%). Most of the subjects (57.6%) had epilepsy and were using anti-epileptic drugs. The majority of subjects had vitamin D deficiency status (56.5%). Conclusion:The clinical profile of cerebral palsy children at Haji Adam Malik Hospital Medan showed that most CP occurred during the perinatal period. Spastic type is the most common type of CP, most CP children experience epilepsy and vitamin D deficiency.

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Hemiplegic (unilateral) cerebral palsy in northern Stockholm: clinical assessment, brain imaging, EEG, epilepsy and aetiologic background factors

Cited by 8 publications

References 26 publications

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

A unique case report of microcephaly and malnutrition in a child with spastic quadriplegic cerebral palsy

Clinical Profile and Vitamin D Status of Cerebral Palsy Children at Haji Adam Malik Hospital Medan

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