Hemisphere asymmetry of alpha burst sequential organization in depression

Cazard, P; Pollak, V.; Jouvent, Roland; Leboyer, Marion; Grob, R; Lesèvre, N

doi:10.1016/0167-8760(89)90006-8

Cited by 10 publications

(13 citation statements)

References 30 publications

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“…The patients showed significant correlations between preexecutive motor activations and self-ratings of symptoms, which suggest that clinical slowing of movement may be associated with neural activation in the brain areas relevant to motor production. We also found nonsignificant differences in lateralization during motor tasks, and previous studies have correlated depressive symptoms with right hemisphere dysfunction (Cazard et al, 1989(Cazard et al, , 1992Narushima et al, 2003). In addition, an electroencephalographic study of the bereitschaftspotential in depressionVa marker of preexecutive motor functionVfound that it is more lateralized to the left during depression and becomes less asymmetric at remission (Khanna et al, 1989).…”

Section: Resultsmentioning

confidence: 59%

Motor Imagery in Bipolar Depression With Slowed Movement

Liberg¹,

Adler²,

Jönsson³

et al. 2013

Journal of Nervous &Amp; Mental Disease

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We hypothesized that motor retardation in bipolar depression is mediated by disruption of the pre-executive stages of motor production. We used functional magnetic resonance imaging to investigate neural activity during motor imagery and motor execution to elucidate whether brain regions that mediate planning, preparation, and control of movement are activated differently in subjects with bipolar depression (n = 9) compared with healthy controls (n = 12). We found significant between-group differences. During motor imagery, the patients activated the posterior medial parietal cortex, the posterior cingulate cortex, the premotor cortex, the prefrontal cortex, and the frontal poles more than the controls did. Activation in the brain areas involved in motor selection, planning, and preparation was altered. In addition, limbic and prefrontal regions associated with self-reference and the default mode network were altered during motor imagery in bipolar depression with motor retardation.

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Section: Resultsmentioning

confidence: 59%

Motor Imagery in Bipolar Depression With Slowed Movement

Liberg¹,

Adler²,

Jönsson³

et al. 2013

Journal of Nervous &Amp; Mental Disease

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“…Increased theta power has also been shown to be positively related to motor, but not verbal, intellectual or emotional aspects of retardation in depression (Nieber and Schlegel, 1992;Nyströmet al, 1988). Hemispheric electric imbalances in depression have, more often than not, been reported with alpha asymmetry indices but lateralization inconsistencies with this alpha band index have also been observed (Swartzburg,1983;Schaffer et al,1983;Cazard et al, 1989;Kano et al, 1992;Bruder et al, 1997;Reid et al, 1988;Davidson, 1998). The finding that greater hemispheric theta rhythm imbalance, as indexed by theta asymmetry and theta coherence, was associated with more severe depression receives some support from Nyström et al, (1988) who reported retarded depression to be positively correlated with frontaltemporal theta power asymmetry.…”

Section: Discussionmentioning

confidence: 99%

Pre-Treatment EEG and It's Relationship to Depression Severity and Paroxetine Treatment Outcome

Knott

Mahoney²,

Kennedy³

et al. 2000

Pharmacopsychiatry

122

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An array of variables have been assessed as potential early predictors of antidepressant response in depressed patients. This exploratory study examined the relationship of clinical outcome, following pharmacotherapeutic treatment, with quantitative electroencephalographic (EEG) features assessed prior to treatment onset. In 70 major affective disorder patients, pre-treatment spectrum-analysed topographic EEG indices (absolute power, relative power, mean frequency, inter-hemispheric power asymmetry and coherence for 4 frequency bands) were assessed in relation to baseline HAM-D ratings and HAM-D rating changes following 6 weeks of open-label paroxetine treatment. EEG slow wave (theta) activities were positively correlated with depression ratings prior to treatment. Of the patients (n = 51) completing treatment, 80% evidenced a >50% reduction in HAM-D ratings. Improved rating changes in general were found to be negatively related to slow (delta and theta) wave activity and positively related to fast (beta) activity at frontal recording sites. Findings are discussed in relation to the neurochemistry and neurobiology of depressive disorders.

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“…An interaction effect, accounting for age and sex, was not signi cant between group and FAA (f = 1.30, p = 0.253, η p 2 = 0.100). However, for between-subjects effects (schizophrenia vs. healthy control), we observed a signi cant difference in F4-F3 with the eyes-open condition (f [2,49] = 3.70, p = 0.032, η p 2 = 0.131). Alpha asymmetry in the schizophrenia group was lower than that in the healthy controls (-0.10 ± 0.04 vs. -0.05 ± 0.05, corrected p = 0.027, 95% CI = 0.01 to 0.10) ( Fig.…”

Section: Resultsmentioning

confidence: 63%

“…There were no signi cant differences in F4-F3 with eyes open between patients with MDD and healthy controls (corrected p = 0.630, 95% CI = -0.02 to 0.07), or between MDD and schizophrenia patients (corrected p = 0.434, 95% CI = -0.02 to 0.08). There were no signi cant differences found in F4-F3 with eyes-closed (f [2,49] = 0.64, p = 0.532, η p 2 = 0.025), or in F8-F7 with eyes-open or -closed (f [2,49] = 0.96, p = 0.391, η p 2 = 0.038; f [2,49] = 0.11, p = 0.896, η p 2 = 0.004). In correlation analysis, there were no associations between alpha asymmetry and clinical symptoms (depression and F4-…”

Section: Resultsmentioning

confidence: 91%

“…Although electroencephalographic frontal alpha asymmetry (FAA) has been suggested to be a clinical biomarker for the abnormal behavioral phenotype of major depressive disorder (MDD) [1][2][3][4][5][6][7][8][9], con icting results in prior research have contested this view [10,11]. A previous meta-analysis of 1,883 individuals with MDD and 2,161 controls found that FAA's diagnostic value was not signi cant [11].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

Jang¹,

Lee

et al. 2020

Preprint

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Background Electroencephalography (EEG) frontal alpha asymmetry (FAA) has been observed in several psychiatric disorders. However, dominance in left or right frontal alpha activity remains inconsistent in patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls. This study compared FAA among patients with MDD, schizophrenia, and healthy control. Methods We recruited 20 patients with MDD, 18 patients with schizophrenia, and 16 healthy individuals. The EEG alpha frequency ranged from 8.0 to 12.0 Hz. FAA was expressed as the difference between absolute power values in both the right and left electrodes in the alpha frequency range (common-log-transformed F4–F3 and F8–F7). Hamilton depression and anxiety rating scales were evaluated in patients with MDD. Positive and negative syndrome scales were evaluated in patients with schizophrenia. Results Patients with schizophrenia showed significantly lower left frontal lobe activity than healthy controls (FAA, schizophrenia vs. healthy: -0.10 ± 0.05 vs. -0.05 ± 0.05). There were no significant differences in FAA between patients with schizophrenia and MDD as well as between patients with MDD and healthy controls. Conclusions The present study suggests that frontal alpha asymmetry indicates a breaking neural activity in schizophrenia. Breaking rhythmic activity as a left-lateralized FAA can be a neuropathological attribute in patients with schizophrenia but lack of sample size and information such as medication and duration of illness, all of which could make it difficult generalize finding.

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Hemisphere asymmetry of alpha burst sequential organization in depression

Cited by 10 publications

References 30 publications

Motor Imagery in Bipolar Depression With Slowed Movement

Motor Imagery in Bipolar Depression With Slowed Movement

Pre-Treatment EEG and It's Relationship to Depression Severity and Paroxetine Treatment Outcome

Comparison of Frontal Alpha Asymmetry Among Schizophrenia Patients, Major Depressive Disorder, and Healthy Controls

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