Hemispheric Asymmetry for Affective Stimulus Processing in Healthy Subjects–A fMRI Study

Beraha, Esther M.; Eggers, Jonathan; Attar, Catherine Hindi; Gutwinski, Stefan; Schlagenhauf, Florian; Stoy, Meline; Sterzer, Philipp; Kienast, Thorsten; Heinz, Andreas; Bermpohl, Felix

doi:10.1371/journal.pone.0046931

Cited by 65 publications

(44 citation statements)

References 60 publications

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“…Again, circuit balance theory can be extended to consider these possibilities, with circuit underactivity found in conduct disorder (e.g., Rubia, 2011) and circuit overactivity related to anxiety and obsessive-compulsive symptoms (e.g., Stern et al, 2012). There may be a lateralizing effect as well here and in other conditions, with the left FSC dysfunction or underactivation leading to depressive symptoms (Grimm et al, 2009) and ADHD symptoms related to right FSC dysfunction or underactivation (Arnsten & Rubia, 2012;Bush, 2011), which would be consistent with hemispheric studies of emotion and behavior (Beraha et al, 2012;Holtgraves & Felton, 2011). It would also explain, for instance, why ADHD tends to be a right dorsolateral hypoactivity problem, why depression appears to be a left dorsolateral hypoactivity problem, and how the orbital-ventral medial circuits are involved in the ''comorbidities'' associated with them (hyperactive orbital functioning in OCD and hypoactive orbital functioning in conduct disorder).…”

Section: Circuit Balance Theory: Implications For Neuropsychological supporting

confidence: 57%

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

Hale

Fitzer

2015

Applied Neuropsychology: Child

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Attention to self and environment form the basis of effective social exchange and relationships. Although implicit in this basic social competency is the ability to be self-aware and responsive to the circumstances of others, many neuropsychologists have yet to understand or measure its basic functions, let alone recognize the brain-behavior relationships that govern this area. Several years ago, interest in "emotional intelligence" rose to the forefront of popular psychology, but we are still unraveling the cortical, subcortical, and neurocellular interactions that produce this nebulous construct, and we are determining how dysfunctional frontal-subcortical and cortico-cerebellar circuitry can lead to aberrant social dynamics and ultimately psychopathology when maladaptive patterns become routinized. In this article, we explore the orbital-ventral medial circuitry thought to govern emotional attention, personal self-regulation, social concern and exchange, and affective aspects of interpersonal relationships. Our examination notes both the dearth of and need for neuropsychological research on the biological basis and measurement of executive regulation of emotional attention, behavioral regulation, and social competence. We conclude with a call for development of neuropsychological measures and methods that can foster differential diagnosis and targeted treatment strategies for children with orbital-ventral medial circuit dysfunction.

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Section: Circuit Balance Theory: Implications For Neuropsychological supporting

confidence: 57%

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

Hale

Fitzer

2015

Applied Neuropsychology: Child

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“…One contested [33] theory, the valence hypothesis, proposes that positive and negative stimuli are differentially processed by the left and right sides of the brain [34]. Indeed, functional MRI reveals activation of the left prefrontal cortex when humans view images perceived as pleasant, and of the right prefrontal cortex for images that elicit negative emotional responses [33, 35, 36]. In rats, a food reward increases neural activity and norepinephrine (NE) release in the left basolateral amygdala (BLA), whereas foot shock causes increased activity and NE release in the right BLA [37, 38].…”

Section: Discussionmentioning

confidence: 99%

Left Habenular Activity Attenuates Fear Responses in Larval Zebrafish

et al. 2017

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Summary Fear responses are defensive states that ensure survival of an organism in the presence of a threat. Perception of an aversive cue causes changes in behavior and physiology, such as freezing and elevated cortisol, followed by a return to the baseline state when the threat is evaded [1]. Neural systems that elicit fear behaviors include the amygdala, hippocampus and medial prefrontal cortex. However, aside from a few examples, little is known about brain regions that promote recovery from an aversive event [2]. Previous studies had implicated the dorsal habenular nuclei in regulating fear responses and boldness in zebrafish [3–7]. We now show that perturbation of the inherent left-right (L-R) asymmetry of the dorsal habenulo-interpeduncular (dHb-IPN) pathway at larval stages expedites the return of locomotor activity following an unexpected negative stimulus, electric shock. Severing habenular efferents to the IPN, or only those from the left dHb, prolongs the freezing behavior that follows shock. Individuals with symmetric, right isomerized dHb also exhibit increased freezing. In contrast, larvae that have symmetric, left-isomerized dHb, or in which just the left dHb-IPN projection is optogenetically activated, rapidly resume swimming post shock. In vivo calcium imaging reveals a neuronal subset, predominantly in the left dHb, whose activation is correlated with resumption of swimming. The results demonstrate functional specialization of the left dHb-IPN pathway in attenuating the response to fear.

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“…13, 29 and 30 for reviews). Reports on this hemispheric asymmetry may in part be due to differences in methodology, valence of the stimuli (in the case of fMRI studies) or anatomical asymmetry 31. Nevertheless, it has been proposed that the left amygdala is more involved in detailed emotional information processing and detecting stimulus arousal, while the right amygdala is more important for rapid and automatic stimulus detection 32.…”

Section: Discussionmentioning

confidence: 99%

A smaller amygdala is associated with anxiety in Parkinson’s disease: a combined FreeSurfer—VBM study

Vriend

Boedhoe

Rutten

et al. 2015

J Neurol Neurosurg Psychiatry

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These results confirm studies in non-PD samples showing lower left amygdalar volume in anxious patients. The results also indicate that the 'psychological' BAI subscale is a better reflection of neural correlates of anxiety in PD. Whether the left amygdalar volume decrease constitutes a premorbid trait, a PD-associated neurobiological susceptibility to anxiety or arises as a consequence of chronic anxiety symptoms remains to be determined by future prospective longitudinal studies. Nonetheless, we speculate that the Parkinson pathology is responsible for the reduction in amygdalar volume and the concomitant development of anxiety symptoms.

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Hemispheric Asymmetry for Affective Stimulus Processing in Healthy Subjects–A fMRI Study

Cited by 65 publications

References 60 publications

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

Evaluating Orbital-Ventral Medial System Regulation of Personal Attention: A Critical Need for Neuropsychological Assessment and Intervention

Left Habenular Activity Attenuates Fear Responses in Larval Zebrafish

A smaller amygdala is associated with anxiety in Parkinson’s disease: a combined FreeSurfer—VBM study

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