Hemispheric asymmetry of the frontolimbic cortex in young adults with borderline personality disorder

Zhou, Qi; Zhong, Mingtian; Yao, Shuqiao; Jin, Xing‐Kun; Liu, Y.; Tan, Changliang; Lee, Seonjoo; Yi, Jinyao

doi:10.1111/acps.12823

Cited by 12 publications

(3 citation statements)

References 64 publications

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“…Additionally, atypically high functional connectivity between the precuneus and frontal lobes has been found to be related to hyperactive processing of internal thoughts and self-referential information in BPD ( 19 ). Our research group has also found several BPD-related structural and functional brain anomalies, including enlarged GMVs of the right PCC and precuneus with resting-state (rs) brain hypoactivity ( 11 , 20 ), disrupted white matter integrity and functional connectivity of the frontal medial cortex ( 20 , 21 ), and augmented asymmetry and disturbed resting-state functional connectivity of the frontolimbic cortex ( 20 , 22 ).…”

Section: Introductionmentioning

confidence: 77%

Functional Connectivity Density, Local Brain Spontaneous Activity, and Their Coupling Strengths in Patients With Borderline Personality Disorder

et al. 2018

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In this study, combining degree centrality (DC) and fractional amplitude of low frequency fluctuation (fALFF) analyses of resting state (rs)-functional magnetic resonance imaging (fMRI) data, we aimed to explore functional connectivity density, local brain spontaneous activity, and their coupling strengths in borderline personality disorder (BPD). Forty-three BPD patients and 39 demographically-matched controls underwent rs-fMRI after completing a series of psychological tests. Two-sample t-tests were performed to compare DC and fALFF between these two groups. Across-voxel correlation analysis was conducted to assess DC-fALFF coupling strengths in each group. Imaging parameters and psychological variables were correlated by Pearson correlation analysis in the BPD group. Altered DC and fALFF values in the BPD group, compared with the control group, were distributed mainly in default mode network (DMN), and DC-fALFF coupling strengths were decreased in the left middle temporal gyrus (MTG) and right precuneus in the BPD group. Additionally, insecure attachment scores correlated positively with left precuneus DC and negatively with fALFF of the right posterior cingulate cortex (PCC) in the BPD group. These altered DC and fALFF findings indicate that the BPD patients had disturbed functional connectivity density and local spontaneous activity in the DMN compared with control subjects. Their decreased connectivity-amplitude coupling suggests that the left MTG and right precuneus may be functional impairment hubs in BPD. Disturbed rs function in the left precuneus and right PCC might underlie insecure attachment in BPD.

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Section: Introductionmentioning

confidence: 77%

Functional Connectivity Density, Local Brain Spontaneous Activity, and Their Coupling Strengths in Patients With Borderline Personality Disorder

et al. 2018

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“…Deficits in affective and cognitive brain functions and alterations in emotion-attention interaction are seen in psychiatric, neurodegenerative and neurodevelopmental disorders. Abnormal brain lateralization has been reported, for example, in schizophrenia [19,20], borderline personality disorder (BPD) [149], FTD [33] and ADHD [150], and is thought to account for some of the cognitive and affective deficits and social challenges linked with these disorders. Hypo-or hyperactivity or alteration in normal activity balance between the two hemispheres is reflected in FAA, and alteration in emotion-attention interaction likely reflected in the novel eFAA index.…”

Section: Emotional Modulation Of Faa-a Novel Biomarker For Rh Emotion-attention Interactionmentioning

confidence: 99%

Emotion-Attention Interaction in the Right Hemisphere

Hartikainen

2021

Brain Sciences

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Hemispheric asymmetries in affective and cognitive functions have been extensively studied. While both cerebral hemispheres contribute to most affective and cognitive processes, neuroscientific literature and neuropsychological evidence support an overall right hemispheric dominance for emotion, attention and arousal. Emotional stimuli, especially those with survival value such as threat, tend to be prioritized in attentional resource competition. Arousing unpleasant emotional stimuli have prioritized access, especially to right-lateralized attention networks. Interference of task performance may be observed when limited resources are exhausted by task- and emotion-related processing. Tasks that rely on right hemisphere-dependent processing, like attending to the left visual hemifield or global-level visual features, are especially vulnerable to interference due to attention capture by unpleasant emotional stimuli. The aim of this review is to present literature regarding the special role of the right hemisphere in affective and attentional brain processes and their interaction. Furthermore, clinical and technological implications of this interaction will be presented. Initially, the effects of focal right hemisphere lesion or atrophy on emotional functions will be introduced. Neurological right hemisphere syndromes including aprosodia, anosognosia and neglect, which further point to the predominance of the intact right hemisphere in emotion, attention and arousal will be presented. Then there will be a brief review of electrophysiological evidence, as well as evidence from patients with neglect that support attention capture by emotional stimuli in the right hemisphere. Subsequently, experimental work on the interaction of emotion, attention and cognition in the right hemispheres of healthy subjects will be presented. Finally, clinical implications for better understanding and assessment of alterations in emotion–attention interaction due to brain disorder or treatment, such as neuromodulation, that impact affective brain functions will be discussed. It will be suggested that measuring right hemispheric emotion–attention interactions may provide basis for novel biomarkers of brain health. Such biomarkers allow for improved diagnostics in brain damage and disorders and optimized treatments. To conclude, future technological applications will be outlined regarding brain physiology-based measures that reflect engagement of the right hemisphere in affective and attentional processes.

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“…Notably, preterm birth leads to alterations in the fronto-striatal and temporal lobes, and the development of the limbic region takes place in a critical period of fetal brain development. The fronto-limbic pathway primarily consists of the orbitofrontal, the anterior cingulate, insula, and limbic regions, including the amygdala and hippocampus, which is known as the brain’s affective network, underlying the processing and regulation of emotions [ 14 , 15 , 16 ]. The impact of prematurity on cerebral development and damage has been extensively studied using magnetic resonance imaging (MRI) [ 17 ], which provides sensitive assessments of abnormal morphology and microstructure that correspond with neurodevelopmental outcomes [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Altered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism

Kim

Ahn

Lee

et al. 2022

JCM

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Preterm births are often associated with neurodevelopmental impairment. In the critical developmental period of the fetal brain, preterm birth disrupts cortical maturation. Notably, preterm birth leads to alterations in the fronto-striatal and temporal lobes and the limbic region. Recent advances in MRI acquisition and analysis methods have revealed an integrated approach to the genetic influence on brain structure. Based on imaging studies, we hypothesized that the altered cortical structure observed after preterm birth is associated with common genetic variations. We found that the presence of the minor allele at rs1042778 in OXTR was associated with reduced curvature in the right medial orbitofrontal gyrus (p < 0.001). The presence of the minor allele at rs174576 in FADS2 (p < 0.001) or rs740603 in COMT (p < 0.001) was related to reduced curvature in the left posterior cingulate gyrus. This study provides biological insight into altered cortical curvature at term-equivalent age, suggesting that the common genetic variations related to autism spectrum disorder (ASD) and lipid metabolism may mediate vulnerability to early cortical dysmaturation in preterm infants.

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Hemispheric asymmetry of the frontolimbic cortex in young adults with borderline personality disorder

Abstract: Patients with BPD have greater frontolimbic asymmetry than healthy individuals.

Cited by 12 publications

References 64 publications

Functional Connectivity Density, Local Brain Spontaneous Activity, and Their Coupling Strengths in Patients With Borderline Personality Disorder

Functional Connectivity Density, Local Brain Spontaneous Activity, and Their Coupling Strengths in Patients With Borderline Personality Disorder

Emotion-Attention Interaction in the Right Hemisphere

Altered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism

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