Hemispheric blood flow in the rat after unilateral common carotid occlusion: evolution with time.

Abstract

Acute occlusion of one common carotid artery in the anesthetized normocapnic rat results in a moderate cerebral blood flow (CBF) decrease in both cerebral hemispheres. No asymmetrical perfusion is observed when the overall flow in each hemisphere is considered. The increase in blood flow which normally occurs in hypercapnia is strongly impaired in the cerebral hemisphere on the occluded side resulting in an important asymmetrical hemispheric perfusion. The days (1, 5, 15, 30) following unilateral carotid occlusion normal control CBF values are found in both hemispheres in normocapnic conditions. Hemispheric perfusion asymmetry in hypercapnia also becomes progressively less pronounced with time but a slight asymmetry still persists one month after unilateral carotid occlusion.

L-Type Calcium Channels are Modified in Rat Hippocampus by Short-Term Experimental Ischemia

“…The occlusion of a common carotid in rat does not produce clinical signs of cerebral infarction, as blood supply to the brain is also provided by basilar circulation. However, as reported by Deley et al (1985), a reduction in cerebral blood flow and ischemia occurs that is not completely compensated for by the basilar arteries. Sham-operated and control ligated animals were killed by decapitation; the brains were quickly removed and areas dissected and frozen on dry ice.…”

“…Carotid occlusion in the rat provides a model of mild ischemia, in which a significant reduction of cerebral blood flow occurs (Deley et al, 1985), but which is not so dramatic as to cause evident neuro It is important to note that at this time, the effect is selective for the hippocampus, a cerebral area particularly susceptible to insults of ischemic origin (Brierley and Graham, 1984;Bothe et al , 1987;Deshpande et aI., 1987). In particular, Simon et al (1984) …”

Acute Carotid Occlusion Alters the Activation Flow Coupling Response to Forepaw Stimulation in a Rat Model

“…These results are due, most likely, to an increase in the transit time of blood flow though proximal collateral sources to meet the increasing metabolic needs of the activated area required during functional stimulation. 12,13 It is also interesting to note that there was a significant reduction in the delay to peak and a trend to a decrease in the half-width/half-maximum with occlusion of the ipsilateral carotid artery (contralateral to the recorded hemisphere) compared with preocclusion. This reduction in the temporal characteristics with occlusion of the carotid artery ipsilateral to the stimulated forepaw suggests that increased flow within the proximal vasculature that directly supplies the activated region can more rapidly meet the increased metabolic needs of that activated area.…”

“…12,13 However, with chronic occlusion, baseline flow returns to preoccluded values within a few days. 12 Two studies investigated the effects of transient severe global ischemia (4-vessel occlusion) and reperfusion on the AFC response.…”

“…12,13 However, with chronic occlusion, baseline flow returns to preoccluded values within a few days. 12 Two studies investigated the effects of transient severe global ischemia (4-vessel occlusion) and reperfusion on the AFC response. Dietrich et al 14 reported that functional activation due to whisker stimulation in the rat was reduced for up to 5 days after 4-vessel occlusion, whereas Ueki et al 15 …”