Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder

Ho, New Fei; Li, Zhengjun; Ji, Fang; Wang, Mingyuan; Kuswanto, Carissa Nadia; Sum, Min Yi; Tng, Han Ying; Sitoh, Yih Yian; Sim, Kang; Zhou, Juan

doi:10.1503/jpn.160090

Cited by 32 publications

(14 citation statements)

References 68 publications

(98 reference statements)

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“…Significantly decreased rightward asymmetry in the two connectivity measures of local connections was found in BD patients compared with NC, suggesting evident disruption of WM connections of the right hemisphere. The predominantly right hemispheric disconnections in BD patients were consistent with the abnormal right lateralization of WM in BD patients ( Vederine et al, 2011 ; Ho et al, 2017 ). It has been suggested that the right hemisphere is preferentially involved in emotions ( Schwartz et al, 1975 ; Wheeler et al, 1993 ), visuospatial abilities ( Cullen et al, 2016 ) and that disturbances of the right hemisphere underlie emotion dysregulation and visuospatial processing deficits ( Caligiuri et al, 2004 ).…”

Section: Discussionsupporting

confidence: 66%

“…This feature is thought to have originated from evolutionary, developmental, experiential and pathological factors ( Toga and Thompson, 2003 ) and is a prominent characteristic of human brain development. Abnormal hemispheric lateralization has long been proposed to be a consequence of altered neurodevelopment in individuals with psychotic disorders ( Ho et al, 2017 ). Studies on white matter (WM) have shown that aberrant brain region asymmetries are highly correlated with disturbed functions such as executive function ( Yin et al, 2013 ), emotion ( Schwartz et al, 1975 ; Schulte et al, 2012 ), and language ( O’Donoghue et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder

Liu

Yan

et al. 2020

Front. Neuroinform.

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Neuroimaging studies suggest disrupted connections of the brain white matter (WM) network in bipolar disorder (BD). A group of highly interconnected high-density structures, termed the 'rich club,' represents an important network for brain functioning. Recent works have revealed abnormal rich club organization in brain networks in BD. However, little is known regarding changes in the rich club organization of the hemispheric WM network in BD. Forty-nine BD patients and fifty-five age-and sex-matched normal controls (NCs) underwent diffusion tensor imaging (DTI). Graph theory approaches were applied to quantify group-specific rich club organization and nodal degree of hemispheric WM networks. We demonstrated that rich club organization of hemispheric WM networks in BD was disrupted, with disrupted feeder and local connections among hub and peripheral regions located in the default mode network (DMN) and the control execution network (CEN). In addition, BD patients showed abnormal asymmetry in the feeder and local connections, involving the hub and peripheral regions associated with emotion regulation and visuospatial functions. Moreover, the clinical symptoms of BD showed a significant correlation with the aberrant asymmetry in the regional degree of peripheral regions. These findings reveal that BD is closely associated with disrupted feeder and local connections but no alteration in richclub connections in the rich club organization of hemispheric WM networks and provide novel insight into the changes of brain functions in BD.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder

Liu

Yan

et al. 2020

Front. Neuroinform.

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“…Then for MPD, our findings suggest that higher delta/alpha frequency activity is specific to psychosis, and not drug related. The hemispheric differences between BPD and MPD suggest an attenuated deficit over the right hemisphere in BPD, and support BPD as a potential hemispheric disorder 66 , 67 . During REC delta/alpha frequency activity delineates SCZ and MPD from CON.…”

Section: Discussionmentioning

confidence: 62%

Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder

et al. 2018

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Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which leads to reduced ability to attend to relevant information. On this premise, we investigated delta/alpha frequency activity, as this ratio of frequency activity may serve as an effective neurophysiological biomarker. The current study investigated differences in delta/alpha frequency activity, in schizophrenia (SCZ), bipolar I disorder with psychotic features and methamphetamine-induced psychosis. One hundred and nine participants, including individuals with SCZ (n = 28), bipolar I disorder with psychotic features (n = 28), methamphetamine-induced psychotic disorder (MPD) (n = 24) and healthy controls (CON, n = 29). Diagnosis was ascertained with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition disorders and current medication was recorded. EEG was undertaken in three testing conditions: resting eyes open, resting eyes closed and during completion of a simple cognitive task (visual continuous performance task). EEG delta/alpha frequency activity was investigated across these conditions. First, delta/alpha frequency activity during resting eyes closed was higher in SCZ and MPD globally, when compared to CON, then lower for bipolar disorder (BPD) than MPD for right hemisphere. Second, delta/alpha frequency activity during resting eyes open was higher in SCZ, BPD and MPD for all electrodes, except left frontal, when compared to CON. Third, delta/alpha frequency activity during the cognitive task was higher in BPD and MPD for all electrodes, except left frontal, when compared to CON. Assessment of EEG delta/alpha frequency activity supports the delineation of underlying neurophysiological mechanisms present in psychotic disorders, which are likely related to dysfunctional thalamo-cortical connectivity. Delta/alpha frequency activity may provide a useful neurophysiological biomarker to delineate psychotic disorders.

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“…In humans, it is well accepted that there are several lateralization axes in the brain (symbolic communication, perception/action, emotion…) 38 . Moreover, lateralization abnormalities have been observed in patients with schizophrenia and bipolar disorders 39 .…”

Section: Discussionmentioning

confidence: 99%

Brain lateralization probed by water diffusion at the atomic to micrometric scale

Natali

Dolce

Peters

et al. 2019

Sci Rep

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Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisphere using neutron diffraction. 4.7 T dMRI and quasi-elastic neutron experiments highlighted significant differences in the properties of water dynamics in the two hemispheres. The results were interpreted in terms of hemisphere-dependent cellular composition (number of neurons, cell distribution, etc.) as well as specificity of neurological functions (such as preferential networking).

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Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder

Cited by 32 publications

References 68 publications

Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder

Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder

Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder

Brain lateralization probed by water diffusion at the atomic to micrometric scale

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