Hemispheric Lateralization of Motor Thresholds in Relation to Stuttering

Alm, Per A.; Karlsson, Ragnhild; Sundberg, Madeleine; Axelson, Hans

doi:10.1371/journal.pone.0076824

Cited by 22 publications

(19 citation statements)

References 25 publications

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“…Fortunately, the primary motor cortex is the final overarching cortical output region [93] that generates speech behavior. Almost all dysfunctional computations accumulate at this site, making it an attractive target for stuttering research even in the nonspeech domain [94][95][96].…”

Section: Tms Indicates a Restricted Range Of Neuronal Dynamics At Thementioning

confidence: 99%

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

Neef

Anwander

Friederici

2015

Curr Neurol Neurosci Rep

120

139

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Neuroimaging and transcranial magnetic stimulation provide insights into the neuronal mechanisms underlying speech disfluencies in chronic persistent stuttering. In the present paper, the goal is not to provide an exhaustive review of existing literature, but rather to highlight robust findings. We, therefore, conducted a meta-analysis of diffusion tensor imaging studies which have recently implicated disrupted white matter connectivity in stuttering. A reduction of fractional anisotropy in persistent stuttering has been reported at several different loci. Our meta-analysis revealed consistent deficits in the left dorsal stream and in the interhemispheric connections between the sensorimotor cortices. In addition, recent fMRI meta-analyses link stuttering to reduced left fronto-parieto-temporal activation while greater fluency is associated with boosted co-activations of right fronto-parieto-temporal areas. However, the physiological foundation of these irregularities is not accessible with MRI. Complementary, transcranial magnetic stimulation (TMS) reveals local excitatory and inhibitory regulation of cortical dynamics. Applied to a speech motor area, TMS revealed reduced speech-planning-related neuronal dynamics at the level of the primary motor cortex in stuttering. Together, this review provides a focused view of the neurobiology of stuttering to date and may guide the rational design of future research. This future needs to account for the perpetual dynamic interactions between auditory, somatosensory, and speech motor circuits that shape fluent speech.

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Section: Tms Indicates a Restricted Range Of Neuronal Dynamics At Thementioning

confidence: 99%

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

Neef

Anwander

Friederici

2015

Curr Neurol Neurosci Rep

120

139

View full text Add to dashboard Cite

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“…The atypical distribution of brain activity in persons who stutter when compared to controls has been shown both in vocal tasks with fMRI or PET imaging ( Please, see meta-analysis by Belyk et al, 2015 andBudde et al, 2014 ) as well as in non-speech motor studies using TMS (Alm et al, 2013;Neef et al , 2011; see also review by Neef et al, 2015). Many recent studies have implied that the main problem lies in the connective white matter tracts of the brain rather than specific cortical areas.…”

Section: Atypical Lateralizationmentioning

confidence: 99%

“…This is often seen with simultaneous over-activation of right-sided areas such as right frontal operculum and pre-SMA (Belyk et al, 2015;Brown et al, 2005;Budde et al, 2014;Chang et al, 2009;Preibisch et al, 2003). Also non-speech motor function has been abnormally lateralized in recent transcranial magnetic stimulation studies in adults who stutter (Alm et al, 2013;Neef et al, 2011; see also review by Neef et al, 2015). Since the structural and functional aberrations in stuttering persons overlap structures relevant to inhibitory control (for an overview, see Chambers et al, 2009), the CWS could possibly show atypical lateralization of brain activity in an inhibitory task, as well.…”

Section: Introductionmentioning

confidence: 99%

Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Piispala

Määttä

Pääkkönen

et al. 2017

Clinical Neurophysiology

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Please cite this article as: Piispala, J., Mä ättä, S., Pä äkkönen, A., Bloigu, R., Kallio, M., Jansson-Verkasalo, E., Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study, Clinical Neurophysiology (2016), doi: http://dx.doi.org/10.1016/j.clinph. 2016.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study Event related potential, Go/Nogo, children, stuttering, stimulus evaluation, inhibitory control. Highlights 1. Children with stutter (CWS) show atypical brain activation compared to typically developing children (TDC) in a visual Go/Nogo task especially in the right frontal area.2. CWS had prolonged N2 in both conditions while the Nogo P3 component was diminished compared to TDC.3. Stimulus classification and/or inhibitory control may operate abnormally in the CWS. AbstractObjective: The aim of the study was to investigate inhibitory control by evaluating possible differences in the strength and distribution of the brain activity in a visual Go/Nogo task in children who stutter (CWS) compared to typically developing children (TDC).Methods: Eleven CWS and 19 TDC participated. Event related potentials (ERP) were recorded using a 64-channel EEG-cap during an equiprobable visual Go/Nogo task. The global field power (GFP) as well as the mean amplitudes in the P3 time frame were compared between groups. Additionally, the potential maps of the groups were investigated visually in the N2 and P3 time windows.Results: The groups differed significantly in the right frontal area especially in the Nogo condition Conclusions: The CWS show atypical brain activation compared to the TDC in a Go/Nogo task as indexed by the excessive N2-related activity in both conditions and reduced P3-related activity in Nogo condition.Significance: These findings indicate atypical stimulus evaluation and response inhibition processes in CWS.

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“…In addition, both tasks involve rhythmic control, carried out mainly by the cerebellum and the switching of synergic patterns, mediated by the nuclei of the base and by frontal cortical regions. People with stuttering show subtle deficits in manual motor control, which reinforced the idea that oral production and manual motor control are mediated by paths that coincide or communicate with each other 17 . Participants that were able to speak more syllables were the same that were able to perform the higher number of alternated movements.…”

Section: Discussionmentioning

confidence: 68%

Avaliação interdisciplinar da diadococinesia: um estudo piloto

et al. 2017

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RESUMO Diadococinesia é a capacidade de executar movimentos rápidos, repetidos e alternados. Testes de diadococinesia podem avaliar tanto a fala quanto os membros superiores. O objetivo primário foi apresentar um protocolo interdisciplinar de avaliação da diadococinesia. Os objetivos secundários foram comparar o desempenho com os diferentes fonemas do teste de diadococinesia oral (/papapa/, /tatata/, /kakaka/ e /pataka/), comparar o desempenho com as diferentes condições do teste de diadococinesia de membros superiores (realizado com ambos os membros superiores de forma espelhada, apenas com o membro superior direito, apenas com o membro superior esquerdo, com ambos os membros superiores de forma alternada) e investigar possíveis relações entre diadococinesia oral e de membros superiores. Participaram quinze adultos/idosos saudáveis de 40 a 70 anos. Os dados foram representados por estatística descritiva. Os números de sílabas nas condições /papapa/, /tatata/, /kakaka/ e /pataka/ e os números de movimentos nas condições espelhado, direito, esquerdo e alternado foram comparados por ANOVA e correlacionados pelo teste de Pearson. Não houve diferença significativa nos resultados entre os fonemas do teste de diadococinesia oral (p<0,001). Houve diferença entre as condições avaliadas no teste de diadococinesia dos membros superiores (p<0,001). O número de fonemas repetidos esteve correlacionado com o desempenho alternado de membros superiores. Concluiu-se que a correlação entre os escores dos testes de diadococinesia oral e de membros superiores pode ser explicada pelo fato de a programação motora e a linguagem estarem predominantemente representadas no hemisfério esquerdo. Áreas cerebrais comuns/conectadas ou programas motores em comum podem nortear essas tarefas.

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Hemispheric Lateralization of Motor Thresholds in Relation to Stuttering

Cited by 22 publications

References 25 publications

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

The Neurobiological Grounding of Persistent Stuttering: from Structure to Function

Atypical brain activation in children who stutter in a visual Go/Nogo task: An ERP study

Avaliação interdisciplinar da diadococinesia: um estudo piloto

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