Hemispheric specialization during mental imagery of brisk walking

Crémers, Julien; Dessoullières, Aurélie; Garraux, Gaëtan

doi:10.1002/hbm.21255

Cited by 28 publications

(39 citation statements)

References 51 publications

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“…These results were confirmed by fMRI studies in which the actual engagement of the participants in the MI task was controlled 59–61 75 Figure 1. summarises the main results of these imaging studies.…”

Section: Motor Imagery Of Locomotion In Cerebral Imaging: From Healthmentioning

confidence: 55%

Imaging gait disorders in parkinsonism: a review

Maillet

Pollak

Debû

2012

J Neurol Neurosurg Psychiatry

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Gait difficultiesdincluding freezing of gaitdare frequent and disabling symptoms of advanced Parkinson's disease and other parkinsonian syndromes. They respond poorly to current medical and surgical treatments, making patient management very difficult. The underlying pathophysiology remains largely unknown. The late onset of levodopa resistance of Parkinson's disease gait abnormalities has been suggested to result from the progressive extension of the degenerative process to non-dopaminergic structures involved in locomotion, such as cortico-frontal and brainstem networks. Deficiencies in other neurotransmission systems, involving acetylcholine, serotonin or norepinephrine, have also been evoked. Neuroimaging tools appear well suited to decipher the cerebral substrates of parkinsonian gait disorders and their modulation by dopaminergic medication or deep brain stimulation. Here the main functional and metabolic neuroimaging studies aimed at identifying these cerebral networks are reviewed, in both healthy subjects and parkinsonian patients. After a brief overview of the physiology and pathophysiology of gait control, the methodology, main results and limits of the studies published to date are examined. The most promising methods to examine gait difficulties and their response to currently available treatments are then discussed.

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Section: Motor Imagery Of Locomotion In Cerebral Imaging: From Healthmentioning

confidence: 55%

Imaging gait disorders in parkinsonism: a review

Maillet

Pollak

Debû

2012

J Neurol Neurosurg Psychiatry

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“…Within those with PD, we observed significantly lower activity in the left GP than the right, and within controls, we observed higher activity in the left GP with respect to the right, though this difference did not reach significance. One previous investigation also noted increased activity in the left pallidum (but not the right) for healthy adults during imagined walking (Cremers et al, 2012b) however the bilateral changes in PD have not previously been reported. Structural asymmetries in bilateral GP regions may have contributed to these group differences.…”

Section: Discussionmentioning

confidence: 80%

“…We used this approach because we wanted subjects to imagine walking at a self-selected pace. Further, imagining walking faster than preferred can alter BOLD signal (Cremers et al, 2012b; Karachi et al, 2010; Suzuki et al, 2004). …”

Section: Methodsmentioning

confidence: 99%

“…These regions were chosen due to their link to human locomotion (Jahn et al, 2008a; Jahn and Zwergal, 2010) and dysfunction in those with PD (Bruck et al, 2006; Cremers et al, 2012a; Hanakawa et al, 1999; Karachi et al, 2010; Kish et al, 1988; Malouin et al, 2003; Prodoehl et al, 2010; Schweder et al, 2010; Snijders et al, 2011; Spraker et al, 2010). Primary motor cortex was not included as a ROI, as this area does not typically respond to imagined motor tasks (Bakker et al, 2008; Cremers et al, 2012b; de Lange et al, 2005). The ROIs were identified manually for each participant on a high resolution MP-RAGE image warped to Talairach space.…”

Section: Methodsmentioning

confidence: 99%

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Brain activity during complex imagined gait tasks in Parkinson disease

Peterson

Pickett

Duncan

et al. 2014

Clinical Neurophysiology

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Objective Motor imagery during functional magnetic resonance imaging (fMRI) allows assessment of brain activity during tasks, like walking, that cannot be completed in a scanner. We used gait imagery to assess the neural pathophysiology of locomotion in Parkinson disease (PD). Methods Brain activity was measured in five locomotor regions (supplementary motor area (SMA), globus pallidus (GP), putamen, mesencephalic locomotor region, cerebellar locomotor region) during simple (forward) and complex (backward, turning) gait imagery. Brain activity was correlated to overground walking velocity. Results Across tasks, PD exhibited reduced activity in the globus pallidus compared to controls. People with PD, but not controls, exhibited more activity in the SMA during imagined turning compared to forward or backward walking. In PD, walking speed was correlated to brain activity in several regions. Conclusions Altered SMA activity in PD during imagined turning may represent compensatory neural adaptations during complex gait. The lowered activity and positive correlation to locomotor function in GP suggests reduced activity in this region may relate to locomotor dysfunction. Significance This study elucidates changes in neural activity during gait in PD, underscoring the importance of testing simple and complex tasks. Results support a positive relationship between activity in locomotor regions and walking ability.

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“…In contrast to this, right-lateralized frontal lobe functions appear to be associated with operations that should benefit more from perceptually represented content, such as: SWM (20), mental manipulation of objects (21), self-referential mental imagery (22), generating sensory and motoric predictive imagery to help guide ongoing actions (23), holistic integration of plan sequences (14), and integrative/perceptual aspects of category learning (19, 24). …”

Section: The Modelmentioning

confidence: 97%

A Distributed Effects Perspective of Dimensionally Defined Psychiatric Disorders: And Convergent Versus Core Deficit Effects in ADHD

Hale

2014

Front. Psychiatry

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The focus of psychiatric and psychological research has arguably shifted from brain damage and psychosis to more common forms of psychopathology that reflect extremes variants of otherwise normal cognitive and behavioral characteristics. Now, in addition to trying to understand overtly damaged brain-function (flat tire effects), we are also seeking to understand liabilities associated with non-optimized, but otherwise intact, cognitive and behavioral abilities (poor tuning effects). This shift has pushed us to evolve our investigational strategies to more broadly consider whole-brain integrated brain systems, as well as seek to develop more specific quantifiable indicators of impoverished brain function and behavior. This paper discusses such challenges in relation to dimensionally defined psychiatric disorders and presents a novel whole-brain integrated perspective of ADHD brain function pathology.

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Hemispheric specialization during mental imagery of brisk walking

Cited by 28 publications

References 51 publications

Imaging gait disorders in parkinsonism: a review

Imaging gait disorders in parkinsonism: a review

Brain activity during complex imagined gait tasks in Parkinson disease

A Distributed Effects Perspective of Dimensionally Defined Psychiatric Disorders: And Convergent Versus Core Deficit Effects in ADHD

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