Hemispheric Specialization for Language in Children with Different Types of Specific Language Impairment

Pecini, Chiara; Casalini, Claudia; Brizzolara, Daniela; Cipriani, Paola; Pfanner, Lucia; Chilosi, Alberto

doi:10.1016/s0010-9452(08)70890-6

Cited by 17 publications

(9 citation statements)

References 50 publications

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“…Nonetheless, during project therapy children worked on monitoring their level of comprehension and seeking clarification, and on understanding the meanings of words, grammar and narrative sequences, and there was the possibility that this would alter their language comprehension scores. However, the results revealed this did not occur to a significant extent and there are implications for the need to identify effective interventions for children with a receptive component to their primary language difficulties, in the light of emerging evidence for a distinctive aetiology in regard to lower heritability and the involvement of more generalised processing deficits relative to specific expressive delay, [174][175][176] and in view of the poorer long-term outcomes and of the more persistent nature of mixed receptive-expressive impairment. 37,42,[177][178][179][180][181] The children in the present study with specific expressive delay had higher expressive and receptive language scores on average at T1 compared with the children with mixed receptive-expressive delay and made significantly greater progress, providing further evidence that the improvements in their scores following intervention cannot be accounted for merely by regression to the mean.…”

Section: Findings In the Context Of The Literaturementioning

confidence: 90%

A randomised controlled trial and economic evaluation of direct versus indirect and individual versus group modes of speech and language therapy for children with primary language impairment

Boyle

McCartney

Forbes³

et al. 2007

Health Technol Assess

134

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SLTAs can act as effective surrogates for SLTs in the delivery of services within primary schools to children with primary language impairment who do not to require the specialist skills of an SLT. Generalising the central estimates of the relative cost of different therapy modes to other educational/health systems is possible, but the precise differences reported in resource use need to be qualified by the level of programme intensity and other characteristic features of education and therapy services that may differ from those observed in this trial. Further research is needed into effective interventions for receptive language problems and also investigations of the efficacy of the relationship between dose and treatment effect in both expressive and receptive language. Research is also needed into models of integrative service delivery, cluster models of delivery via integrated community schools, and the involvement of class teachers, classroom assistants and parents/carers. There is also a need for studies to identify the characteristics of children who are most likely to succeed with indirect intervention approaches, and also to evaluate alternative methods of working with those who may benefit from different modes. Finally, research to refine the therapy manual would also be helpful.

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Section: Findings In the Context Of The Literaturementioning

confidence: 90%

A randomised controlled trial and economic evaluation of direct versus indirect and individual versus group modes of speech and language therapy for children with primary language impairment

Boyle

McCartney

Forbes³

et al. 2007

Health Technol Assess

134

View full text Add to dashboard Cite

show abstract

“…Reduced left lateralization or rightward asymmetry of language functions have also been reported in healthy left-handers (see Geschwind & Galaburda, 1985; Jorgens et al, 2007; Knecht et al, 2000; Pujol et al, 1999; Szaflarski et al, 2002; Tzourio et al, 1998a) and in a number of other disorders, including developmental stuttering, dyslexia, specific language impairment, attention deficit hyperactivity disorder (ADHD), and schizophrenia (Blomgren et al, 2003; Geschwind & Galaburda, 1985; Pecini et al, 2005; Wehner et al, 2007). These complex neurodevelopmental disorders, which share increased rates of atypical lateralization of language, all have heterogeneous co-morbid behavioral characteristics, with overlapping subgroups often identified.…”

Section: Introductionmentioning

confidence: 94%

Language laterality in autism spectrum disorder and typical controls: A functional, volumetric, and diffusion tensor MRI study

et al. 2010

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Language and communication deficits are among the core features of autism spectrum disorder (ASD). Reduced or reversed asymmetry of language has been found in a number of disorders, including ASD. Studies of healthy adults have found an association between language laterality and anatomical measures but this has not been systematically investigated in ASD. The goal of this study was to examine differences in gray matter volume of perisylvian language regions, connections between language regions, and language abilities in individuals with typical left lateralized language compared to those with atypical (bilateral or right) asymmetry of language functions. 14 adolescent boys with ASD and 20 typically developing adolescent boys participated, including equal numbers of left-and right-handed individuals in each group. Participants with typical left lateralized language activation had smaller frontal language region volume and higher fractional anisotropy of the arcuate fasciculus compared to the group with atypical language laterality, across both ASD and control participants. The group with typical language asymmetry included the most right-handed controls and fewest left-handers with ASD. Atypical language laterality was more prevalent in the ASD than control group. These findings support an association between laterality of language function and language region anatomy. They also suggest anatomical differences may be more associated with variation in language laterality than specifically with ASD. Language laterality therefore may provide a novel way of subdividing samples, resulting in more homogenous groups for research into genetic and neurocognitive foundations of developmental disorders.

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“…Atypical lateralization in persons with ASD and person with typical development may lead to decreased hemispheric specialization, which may affect highly lateralized tasks, such as language ability. Additionally, it is interesting to note that atypical asymmetry of language (as measured by functional activation during language tasks) has been reported in typically developing left-handed individuals [Jorgens, Kleiser, Indefrey, & Seitz, 2007;Tzourio, Crivello, Mellet, Nkanga-Ngila, & Mazoyer, 1998], as well as in individuals with reading disorders [Wehner, Ahlfors, & Mody, 2007], developmental stuttering [Blomgren, Nagarajan, Lee, Li, & Alvord, 2003], specific language impairment [Pecini et al, 2005], attention deficit hyperactivity disorder [Hale et al, 2010;Keune et al, 2011], and schizophrenia [Sommer, Ramsey, Kahn, Aleman, & Bouma, 2001]. These disorders may have behavioral symptoms that overlap with ASD, which makes this an intriguing area of study.…”

Section: Atypical Lateralization In Persons With Asdmentioning

confidence: 99%

Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review

et al. 2012

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White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc.

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Hemispheric Specialization for Language in Children with Different Types of Specific Language Impairment

Cited by 17 publications

References 50 publications

A randomised controlled trial and economic evaluation of direct versus indirect and individual versus group modes of speech and language therapy for children with primary language impairment

A randomised controlled trial and economic evaluation of direct versus indirect and individual versus group modes of speech and language therapy for children with primary language impairment

Language laterality in autism spectrum disorder and typical controls: A functional, volumetric, and diffusion tensor MRI study

Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review

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