Hemispheric Specialization in Human Dorsal Frontal Cortex and Medial Temporal Lobe for Verbal and Nonverbal Memory Encoding

Kelley, William M.; Miezin, Francis M.; McDermott, Kathleen B.; Buckner, Randy L.; Raichle, Marcus E.; Cohen, Neal J.; Ollinger, John M.; Akbudak, Erbil; Conturo, Thomas E.; Snyder, Abraham Z.; Petersen, Steven E.

doi:10.1016/s0896-6273(00)80474-2

Cited by 744 publications

(511 citation statements)

References 36 publications

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“…The validity of the claim for regional and hemispheric specificity of functional deficits associated with brain lesions has received increasing support more recently from studies of functional deficits caused by small seizure foci or by surgically induced lesions in the mesial-temporal lobe (Jones-Gotman, 1986;Katz et al, 1989;Loring & Meador, 2001;Sass et al, 1990;Sass et al, 1991;Trenerry et al, 1993). Similar hemispheric specialization of medial-temporal lobe structures in subserving verbal and nonverbal tasks has been demonstrated in functional MRI studies (Kelley et al, 1998;Kirchhoff, Wagner, Maril, & Stern, 2000;Wagner et al, 1998) and PET studies (Haier et al, 1992), both of which showed selective activation of the right hippocampus during visuospatial tasks. Hemispheric specialization has also been suggested in magnetoencephalography studies that show activation of the left hippocampus during word recognition and activation of the right hippocampus during visual recognition tasks (Breier, Simos, Zouridakis, & Papanicolaou, 1999;Papanicolaou et al, 2002).…”

Section: Regional and Hemispheric Specializationmentioning

confidence: 84%

Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Amat

Bansal

Whiteman

et al. 2008

Brain and Cognition

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Several prior imaging studies of healthy adults have correlated volumes of the hippocampus and amygdala with measures of general intelligence (IQ), with variable results. In this study, we assessed correlations between volumes of the hippocampus and amygdala and full-scale IQ scores (FSIQ) using a method of image analysis that permits detailed regional mapping of this correlation throughout the surface contour of these brain structures. We delineated the hippocampus and amygdala in high-resolution magnetic resonance images of the brain from 34 healthy individuals. We then correlated FSIQ with overall volumes and with the surface morphologies of each of these structures. Hippocampus volumes correlated significantly and inversely with FSIQ independently of gender, age, socioeconomic status, and whole brain volume. Left and right hippocampus volumes correlated respectively with verbal and performance IQ subscales. Higher IQs were significantly associated with large inward deformations of the surface of the anterior hippocampus bilaterally. These findings suggest that a smaller anterior hippocampus contributes to an increased efficiency of neural processing that subserves overall intelligence.

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Section: Regional and Hemispheric Specializationmentioning

confidence: 84%

Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Amat

Bansal

Whiteman

et al. 2008

Brain and Cognition

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“…Our results are inconsistent, however, with the findings of Casey et al (1998), who failed to observe laterality differences in task performance using the same task we did. 3 Kelley et al (1998) tested participants on word and line drawings of objects and faces. Left dorsal frontal activation was observed for the encoding of words, and fight dorsal frontal activation was observed for the encoding of faces.…”

Section: Discussionmentioning

confidence: 99%

Functional neuroanatomy of spatial working memory in children.

Nelson¹,

Monk²,

Lin³

et al. 2000

Developmental Psychology

200

140

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Functional magnetic resonance imaging (fMRI) was used to examine spatial working memory in 8-to 11-year-old children tested under three conditions. In the visual condition, children were asked to examine the location of a dot on a screen. In the motor condition, children were instructed to push a button that corresponded to the location of a dot presented on a screen. In the memory condition, children were asked to remember the location of a dot presented 1 or 2 trials previously. Subtracting the activation of the motor condition from the memory condition revealed activity in the dorsal aspects of the prefrontal cortex and in the posterior parietal and anterior cingulate cortex. These findings were also obtained in the analysis of the memory minus visual conditions except that motor cortex activation was also observed. These findings parallel those reported in comparable studies of adults and suggest that fMRI may be a useful means of examining function-structure relations in developmental populations.According to Baddeley (1986), working memory is the process of temporarily maintaining information in an active form so that it is available for further processing. Not surprisingly, this cognitive component may be involved in many common tasks such as planning, decision making, spatial navigation, and strategy use. In the context of development, it is likely that working memory may underlie the emergence of many abilities that are considered hallmarks of mature, higher level cognitive functions. In this article we explore the functional neuroanatomy of working memory in 8-to 11-year-old prepubescent children.In the adult, the neural substrate for working memory varies depending on what is required of the person (see Goldman-Rakic, 1996). For example, dorsal aspects of the frontal cortex (including the superior and middle frontal gyrus) may be disproportionately

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“…The first six regions lie in the ventral visual pathway that participates in face processing. The right prefrontal region chosen was activated when non-famous faces were presented for encoding [Chee and Caplan, 2002;Kelley et al, 1998]. …”

Section: Imaging and Image Analysismentioning

confidence: 99%

Stimulus repetition and hemodynamic response refractoriness in event‐related fMRI

Soon

Venkatraman

Chee

2003

Human Brain Mapping

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Abstract:We investigated the extent of hemodynamic recovery following the paired presentation of either identical or different faces at two different inter-stimulus intervals (ISI). Signal recovery was consistently better at an ISI of 6 sec compared to 3 sec. Significantly less signal recovery was associated with identical faces compared to different faces in bilateral mid-fusiform and right prefrontal regions but not in the calcarine and posterior fusiform regions. Repetition suppression effects contributed significantly to incomplete signal recovery in a region-specific manner. Simulations using empirically derived data suggest that experiments with shorter ISI (average 4.5-6.0 sec) are as sensitive as experiments with intermediate ISI (average 9 sec) in detecting response differences if experimental duration is equivalent. However, designs using intermediate ISI may be more appropriate if the expected difference in responses is small and if the number of suitable stimuli is limited. Hum. Brain Mapping 20:1-12, 2003.

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Hemispheric Specialization in Human Dorsal Frontal Cortex and Medial Temporal Lobe for Verbal and Nonverbal Memory Encoding

Cited by 744 publications

References 36 publications

Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Functional neuroanatomy of spatial working memory in children.

Stimulus repetition and hemodynamic response refractoriness in event‐related fMRI

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