Hemmung der arteriosklerotischen Plaqueentstehung durch Knoblauch

Siegel, G.; Michel, Frank; Ploch, M.; Rodríguez, Miguel Delgado; Malmsten, Martin

doi:10.1007/s10354-004-0117-5

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…The 1 The abbreviations used are: PLP, pyridoxal-5Ј-phosphate; aAT, ar-resolution of 1.53 Å, it can be considered well refined. An example for the quality of the final electron density is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

The Active Principle of Garlic at Atomic Resolution

Kuettner¹,

Hilgenfeld²,

Weiss³

2002

Journal of Biological Chemistry

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Despite the fact that many cultures around the world value and utilize garlic as a fundamental component of their cuisine as well as of their medicine cabinets, relatively little is known about the plant's protein configuration that is responsible for the specific properties of garlic. Here, we report the three-dimensional structure of the garlic enzyme alliinase at 1.5 Å resolution. Alliinase constitutes the major protein component in garlic bulbs, and it is able to cleave carbon-sulfur bonds. The active enzyme is a pyridoxal-5-phosphate-dependent homodimeric glycoprotein and belongs to the class I family of pyridoxal-5-phosphate-dependent enzymes. In addition, it contains a novel epidermal growth factorlike domain that makes it unique among all pyridoxal-5-phosphate-dependent enzymes.

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Section: Resultsmentioning

confidence: 99%

The Active Principle of Garlic at Atomic Resolution

Kuettner¹,

Hilgenfeld²,

Weiss³

2002

Journal of Biological Chemistry

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“…3. HCA (hierarchical cluster analysis) is widely used to classify samples because of its effectiveness in showing the relationship between them (Zhao, Fan, Yu, & Cheng, 2004). In this study, we classified tea leaves by HCA to verify the reliability of our HPLC fingerprint results (Liu et al, 2015).…”

Section: Pca (Principal Component Analysis) Elects Fewer Important Vari-mentioning

confidence: 99%

The contribution ratio of various characteristic tea compounds in antioxidant capacity by DPPH assay

Lin

et al. 2020

J Food Biochem

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Tea is a worldwide health beneficial beverage for its antioxidant ability. 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) assay is a common method to measure the antioxidant capacity of tea compounds, yet the contribution ratio of various characteristic tea compounds is still unclear. high‐performance liquid chromatography (HPLC) was used to examine the content of polyphenol compounds in 24 tea samples from four tea categories (green tea, white tea, oolong tea, and black tea). Based on the results of DPPH and HPLC, contribution ratio of each tea compound was analyzed by the Pearson correlation analysis and the partial least squares regression (PLSR). The Pearson correlation analysis showed that the order of correlation between the area of 13 peaks and the antioxidant ability of tea samples was x8 > x6 > x3 > x13 > x10 > x7 > x2 > x5 > x11 > x9 > x4 > x12 > x1; the regression equation fit by PLSR was Y = 47.258 − 0.760x1 + 0.287x2 − 1.484x3 − 0.569x4 + 0.674x5 + 2.257x6 + 1.698x7 + 1.389x8 − 0.188x9 + 0.467x10 + 0.297x11 + 1.314x12 + 0.963x13. We identified nine common peaks by reference standard substances: the x3 was gallic acid (GA), x4 was theobromine, x5 was catechuic acid (CA), x6 was epigallocatechin (EGC), x8 was epigallocatechin gallate (EGCG), x9 was caffeine, x10 was epicatechin (EC), x12 was epicatechin gallate (ECG), and x13 was gallocatechin gallate (GCG). Based on the study of spectrum‐effect correlation, we obtain a better understanding of the antioxidant activity of complex tea polyphenols component. Practical applications Identify the contribution of specific chemical compound to antioxidant activity by the coefficients in PLSR equation and provide a deeper insight into the joint effect of multiple ingredients of tea. Further, we can infer the DPPH free radical scavenging ability of a new kind of tea by the PLSR equation without chemical detection.

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“…It is a blood thinner that helps to lower both high blood pressure and blood triglycerides. The presence of diallyl sulphide and thiacremonone has been found to confer on it anti-arthritic property [37]. Garlic also has anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

AROC in Agric

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Hemmung der arteriosklerotischen Plaqueentstehung durch Knoblauch

Cited by 9 publications

References 18 publications

The Active Principle of Garlic at Atomic Resolution

The Active Principle of Garlic at Atomic Resolution

The contribution ratio of various characteristic tea compounds in antioxidant capacity by DPPH assay

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