Hemmung von Epithelregeneration und cornealer Wundheilung beim Kaninchen durch Antimetaboliten

Wollensak, J.; Kypke, W.

doi:10.1007/bf00678401

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1972

1981

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Cited by 12 publications

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“…If, as in group 4, the IDU medication is discontinued after 5 days, the epithelium is completed after an additional 3 days. Wollensak & Kypke (1965) observed a longer time of healing. This may be due to different experimental conditions.…”

Section: Discussionmentioning

confidence: 91%

The Effect of 5‐iodo‐2′deoxyuridine (Idu) and Dexamethasone on Corneal Wound Healing in the Rabbit

Puelhorn

Sosath

Thiel

1978

Acta Ophthalmologica

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Using lamellar keratectomy as a model, the effect of 5-iodo-2' deoxyuridine (IDU) and dexamethasone on epithelial regeneration and stromal wound healing in rabbits was studied. Under IDU medication, there was a dose-dependent delay in both epithelial and stromal regeneration of the cornea. This negative effect of IDU was considerably intensified by additional doses of dexamethasone. When IDU was used alone, regeneration in the wound was delayed by five days in comparison to the control eyes. When dexamethasone was added, the delay was prolonged to about 10 days. The results are discussed and compared with the available literature.

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Section: Discussionmentioning

confidence: 91%