Hemocompatibility and anti-bacterial properties of silver doped diamond-like carbon prepared by pulsed filtered cathodic vacuum arc deposition

a b s t r a c tProduction of wear debris has been linked to the failure of numerous hip implants. With the current focus on increasing the implant longevity, thus wear and corrosion resistance is important. Hard coatings have the potential to reduce the wear and corrosion. Diamond like Carbon (DLC) coatings exhibit properties that could make them viable for implants. This paper critically reviews previously published research into usage of DLC coatings for implants. Overall DLCs seem to be an effective coating for implants but with the variance in results, further testing is required for clarification of use.

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“…However the research provides no information about the size and distribution of the deposits in the matrix [21].…”

Section: Dopantsmentioning

confidence: 99%

Diamond like carbon coatings for potential application in biological implants—a review

Love

Cook

Harvey

et al. 2013

Tribology International

237

118

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“…There are many methods that have been performed to deposit silver on titanium surfaces, such as plasma immersion ion implantation and deposition using pulsed fi ltered cathodic vacuum arc, physical vapor deposition, etc. [ 38,39 ] In this study, silver coating was achieved by DC magnetron sputtering from a pure silver target.…”

Section: Introductionmentioning

confidence: 99%

Harnessing the Multifunctionality in Nature: A Bioactive Agent Release System with Self‐Antimicrobial and Immunomodulatory Properties

Özçelik

Vrana

Gudima

et al. 2015

Adv Healthcare Materials

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Major problems with biomedical devices in particular implants located in nonsterile environments concern: (i) excessive immune response to the implant, (ii) development of bacterial biofi lms, and (iii) yeast and fungi infections. An original multifunctional coating that addresses all these issues concomitantly is developed. A new exponentially growing polyelectrolyte multilayer fi lm based on polyarginine (PAR) and hyaluronic acid (HA) is designed. The fi lms have a strong inhibitory effect on the production of infl ammatory cytokines released by human primary macrophage subpopulations. This could reduce potential chronic infl ammatory reaction following implantation. Next, it is shown that PAR, due to its positive charges, has an antimicrobial activity in fi lm format against Staphylococcus aureus for 24 h. In order to have a long-term antimicrobial activity, a precursor nanoscale silver coating is deposited on the surface before adding the PAR/HA fi lms. Moreover, the PAR/HA fi lms can be easily further functionalized by embedding antimicrobial peptides, like catestatin (CAT), a natural host defense peptide. This PAR/HA+CAT fi lm proves to be effective as an antimicrobial coating against yeast and fungi and its cytocompatibility is also assessed. Finally, this all-in-one system constitutes an original strategy to limit infl ammation and prevents bacteria, yeast, and fungi infections.

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“…Limited studies regarding bacterial adhesion on the different carbon films have been published before (Wang et al, 2004, Ishihara et al, 2006, Jones et al, 2006, Katsikogianni et al, 2006, Morrison et al, 2006, Kwok et al, 2007, Zhao et al, 2007, Zhou et al, 2008, Kinnari et al, 2008. These works included mainly DLC or modified-DLC films and concluded that the carbon surface has great biocompatibility properties and good resistance to microbial adhesion.…”

Section: Bacterial Adhesionmentioning

confidence: 99%

“…Silver antimicrobial properties have been recognized since historic times (Klasen, 2000, Burrell, 2003, and the coating of medical devices with silver coatings (Ewald et al, 2006, Bosetti et al, 2002, Darouiche, 1999, Schierholz et al, 1998 or the addition of silver nanoparticles (Chen et al, 2006, Kwok et al, 2007, Rai et al, 2009) into the material's surface might be a good method to prevent device-associated infections by physical routes instead of the chemical routes mentioned above. Silver exhibits a rather broad-spectrum antimicrobial activity in vitro by binding both to microbial DNA, preventing bacterial replication, and to the sulfhydryl groups of the metabolic enzymes of the bacterial electron transport chain, causing their inactivation (Darouiche, 1999).…”

Section: Silver -Amorphous Carbon Films (A-c:ag)mentioning

confidence: 99%

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

Almaguer-Flore¹,

Rodil²,

Olivares-Navarrete³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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Hemocompatibility and anti-bacterial properties of silver doped diamond-like carbon prepared by pulsed filtered cathodic vacuum arc deposition

Cited by 104 publications

References 17 publications

Diamond like carbon coatings for potential application in biological implants—a review

Diamond like carbon coatings for potential application in biological implants—a review

Harnessing the Multifunctionality in Nature: A Bioactive Agent Release System with Self‐Antimicrobial and Immunomodulatory Properties

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

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