Hemocompatibility enhancement of polyethersulfone membranes: Strategies and challenges

Song, Xin; Ji, Haifeng; Zhao, Weifeng; Sun, Shudong; Zhao, Changsheng

doi:10.1016/j.advmem.2021.100013

Cited by 17 publications

(19 citation statements)

References 227 publications

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“…PDMS is a commonly used cytocompatible material for in vitro cell-contact devices, as it can be easily processed into various shapes . PP is a cost-effective medical-grade plastic material with excellent chemical resistance, thermal stability, and nontoxicity, making it widely used in medical materials, e.g., surgical sutures, medical implants, and syringes. , PES and PSF are the core materials of hemodialyzer due to their outstanding biocompatibility, thermal and chemical stability, as well as mechanical properties . PS has good strength and plasticity and no toxicity and has become the preferred material in biomedical applications .…”

Section: Resultsmentioning

confidence: 99%

“…48,49 PES and PSF are the core materials of hemodialyzer due to their outstanding biocompatibility, thermal and chemical stability, as well as mechanical properties. 50 PS has good strength and plasticity and no toxicity and has become the preferred material in biomedical applications. 51 The benchmark material for in vitro cell culture is the plasma-treated PS with reduced water contact angle, which is known as TCPS and recognized as the reference here.…”

Section: Materials Hydrophobicity Affects Cell Adhesionmentioning

confidence: 99%

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Phase Separation Microparticles as a Three-Dimensional Cell Culture System To Promote Stem Cell Expansion

Qiu

Shi

et al. 2023

Biomacromolecules

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Stem cell therapy is developing rapidly, but existing expansion techniques are insufficient for the use of a large number of cells. The surface chemistry and surface morphology characteristics of materials play a critical role in cellular behaviors and functions and have guiding significance for the design of biomaterials. Many studies have proven that these factors are essential to affect cell adhesion and growth. How to design a suitable biomaterial interface is the focus of recent studies. Here, the mechanosensing of human adipose-derived stem cells (hASC) on a set of materials and materials with various porosity is systematically studied. Guided by the mechanism discoveries, three-dimensional (3D) microparticles with optimized hydrophilicity and morphology are designed via liquid–liquid phase separation technology. The microparticles support scalable stem cell culture and extracellular matrix (ECM) collection, exhibiting great potential for stem cell applications.

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Section: Resultsmentioning

confidence: 99%

Section: Materials Hydrophobicity Affects Cell Adhesionmentioning

confidence: 99%

Phase Separation Microparticles as a Three-Dimensional Cell Culture System To Promote Stem Cell Expansion

Qiu

Shi

et al. 2023

Biomacromolecules

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“…The major drawbacks of using semipermeable membranes in hemodialysis are the hemocompatibility through blood exposure to the membrane’s material, which could lead to activation of proinflammatory molecules, and the incapacity of successfully removing some larger toxins molecules [ 44 ]. The development of upgraded hemodialysis membranes for increased hemocompatibility and anticoagulant properties was reported [ 44 , 50 , 51 , 52 , 53 , 54 ]. These membranes were obtained from natural or synthetic polymers, such as polysulfone (PSF) [ 55 , 56 , 57 ], polyethersulfone (PES) [ 58 , 59 ], polyvinyl alcohol (PVA) [ 60 , 61 , 62 ], cellulose triacetate (CTA) [ 63 , 64 , 65 ], polymethylmethacrylate (PMMA) [ 66 , 67 ], polyacrylonitrile (PAN) [ 53 , 68 ], and polyamide (PA) [ 67 ].…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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“…The drawback of PSF is having a hydrophobic nature, which could be conducive to protein adsorption, platelet adhesion and clotting enzymes, which directly leads to thrombosis [ 38 ]. The functionalization of PSF surfaces changes the hydrophilicity of the surfaces, leading to an increase in the hemocompatibility and anticoagulant properties of the PSF membrane [ 41 , 53 ]. The functionalization of the PSF could be achieved at every step of the forming phase of the polymers, such as the functionalization of PSF in solution followed by membrane synthesis or formation, and functionalization of the surface of PSF membrane [ 54 ].…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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The field of membrane materials is one of the most dynamic due to the continuously changing requirements regarding the selectivity and the upgradation of the materials developed with the constantly changing needs. Two membrane processes are essential at present, not for development, but for everyday life—desalination and hemodialysis. Hemodialysis has preserved life and increased life expectancy over the past 60–70 years for tens of millions of people with chronic kidney dysfunction. In addition to the challenges related to the efficiency and separative properties of the membranes, the biggest challenge remained and still remains the assurance of hemocompatibility—not affecting the blood during its recirculation outside the body for 4 h once every two days. This review presents the latest research carried out in the field of functionalization of polysulfone membranes (the most used polymer in the preparation of membranes for hemodialysis) with the purpose of increasing the hemocompatibility and efficiency of the separation process itself with a decreasing impact on the body.

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Hemocompatibility enhancement of polyethersulfone membranes: Strategies and challenges

Cited by 17 publications

References 227 publications

Phase Separation Microparticles as a Three-Dimensional Cell Culture System To Promote Stem Cell Expansion

Phase Separation Microparticles as a Three-Dimensional Cell Culture System To Promote Stem Cell Expansion

Polymeric Membranes for Biomedical Applications

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

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