Hemocompatibility evaluation of poly(1,8‐octanediol citrate) blend polyethersulfone membranes

Abstract

In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0-3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin-antithrombin III (TAT), complement (C3a and C5a) activation and Ca absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1510-1520, 2017.

Removal of As(iii) and As(v) from water using green, silica-based ceramic hollow fibre membranes via direct contact membrane distillation

“…However, polymers have disadvantages in that they are unable to act in harsh conditions such as high temperature and high chemical resistance, which are crucial properties for membranes in MD. [15][16][17][18][19] Ceramic membranes are able to tackle this problem, as they can withstand harsh conditions due to their excellent mechanical stability, chemical stability and thermal resistance. [20][21][22] In general, alumina is the most common material for fabrication of ceramic membranes.…”

Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

“…The hydration capacity of pristine and modified PSF diaphragms depended on the WCA which was measured by an SL 200B contact angle goniometer (KINO, USA). In addition, the internal structure effected partially the biocompatible performances, and the porosity of membranes was applied to evaluate the internal hydrophilicity [24,25]. The porosity was calculated by the following equation:porosity=M1−M0Alρ×100%,where M 1 (g) and M 0 (g) were the quality of pure and modified membranes, respectively, A (m 2 ) was the effective area of surface, l (m) represented the thickness of diaphragms and ρ was the density of water (998 kg m −2 ).…”

“…Open Sci. 8: 210462 applied to evaluate the internal hydrophilicity [24,25]. The porosity was calculated by the following equation:…”

Improved hemodialysis with hemocompatible polyethersulfone hollow fiber membranes: In vitro performance

“…As seen from the Table, the solute rejection of PT-NZ HFMs is better than that exhibited by polyvinylidene fluoride 36 and modified polyvinylidene fluoride membranes, 37 comparable to that of modified cellulose acetate, 38 and slightly lower than that of poly(1,8-octanediol citrate) blend PES. 39 Clearly, the solute rejection result indicates that the PT-NZ HFMs are safer for the hemodialysis application. Toxin clearance study with uremic toxin spiked goat blood.…”