Hemocompatibility of human whole blood on polymers with a phospholipid polar group and its mechanism

Ishihara, Kazuhíko; Oshida, Hiroko; Endo, Yutaka; Ueda, Toshihisa; Watanabe, Akihiko; Nakabayashi, Nobuo

doi:10.1002/jbm.820261202

Cited by 437 publications

(308 citation statements)

References 10 publications

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“…15,16) The PMPC brush has also attracted a great deal of interest because of its excellent biocompatibility 17,18) and its antifouling behavior. 19) In order to understand the mechanism of such excellent biocompatibility and the lubrication behavior, it is very important to examine the swollen structure, the conformation of polyelectrolyte brushes in an aqueous solution, and the dependence on ionic strength in comparison to the solution properties of unbound, free polyelectrolytes.…”

Section: Chain Dimension Of Polyelectrolyte In Solution and Immobilizmentioning

confidence: 99%

Surface and Interface Analyses of Polymer Brushes by Synchrotron Radiation

et al. 2013

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In the present review, we focus on the characterization of polymer brushes by quantum beam, which is regarded as a promising probe of surface and interface analysis. The polymer brushes were prepared on various shapes of surface, and proved to be benefit to various applications. Among them, the polymer brushes grafted on sphere nanoparticles and flat substrates are investigated as representative cases. The static structure of polymer brushes, especially the chain dimension of polymer brushes grafted on nanoparticles and a flat substrate, have been studied by small angle X-ray scattering (SAXS) and neutron reflectivity (NR), respectively. The microscopic dynamical properties of polymer brushes are also expected to be revealed by quantum beam. X-ray photon correlation spectroscopy (XPCS), a technique using a coherent X-ray, is one of the promising methods for microscopically understanding of dynamical properties of polymer brushes. Some of our recent studies about dynamical behavior of polymer brush immobilized nanoparticle by XPCS are also presented.

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Section: Chain Dimension Of Polyelectrolyte In Solution and Immobilizmentioning

confidence: 99%

Surface and Interface Analyses of Polymer Brushes by Synchrotron Radiation

et al. 2013

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“…The expectation of protein resistance is based on the hypothesis that these groups should mimic the lipid component of the cell surface (10) which is supposed to be essentially protein resistant. Ishihara et al (11) have suggested that arrays of such PC moieties attached to a surface in contact with blood will bind phospholipids and organize them into structures that are lipid bilayer-like, and thus protein resistant. The paper by Nakabayashi et al in this volume provides additional data in support of this concept.…”

Section: Theory and Molecular Mechanisms Of Protein Adsorptionmentioning

confidence: 99%

Proteins at Interfaces

Brash

Horbett

1995

ACS Symposium Series

204

119

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Proteins at interfaces are involved in a wide variety of phenomena, including mammalian cell growth in culture, reactions to implanted biomaterials, growth of soil bacteria, and formation of organized layers of proteins at the oil/water and air/water interfaces.This broad range of phenomena has attracted the interest of a correspondingly broad range of scientists and engineers, many with different backgrounds and different perspectives. As a result, the field of proteins at interfaces displays as much breadth as depth, and many of the investigators in this field of research conduct investigations that are unique with respect both to the particular protein/surface system studied and to the methods used. The many different approaches and systems under investigation, and in particular the wide variety of applications towards which the research is directed, means that an overview such as this one which is limited in length, must be selective. In selecting subtopics for discussion we had to be somewhat arbitrary, and therefore tried to focus on broad aspects which are common to most application areas.The contributions to the San Diego Symposium and to this volume represent a significant fraction of the workers who are actively involved in studying the behavior of proteins at interfaces. We have therefore chosen to organize our overview around six major aspects of protein behavior at interfaces which emerged from the Symposium. These aspects are: (1) theory, including molecular mechanisms; (2) competitive adsorption; (3) conformation and orientation of proteins at interfaces; (4) surface chemistry effects on adsorption; (5) the behavior of proteins at fluid interfaces; and (6) effects of proteins on cell interactions with surfaces.For each topic, current understanding is briefly summarized, and the contributions of the articles in this volume are then discussed. Inevitably this type of subdivision is to some extent arbitrary and artificial, so there is some overlap of material from one section to another. We trust, however, that on balance our approach will facilitate the readers' (as well as the authors') task of understanding the state of the art in this field.0097-6156/95/0602-0001$12.75/0

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“…Research in the development of enzyme electrodes for biofuel cell and biosensor applications has been carried out extensively in recent years. Studies on understanding the reaction mechanisms of enzyme catalytic reactions [14,15], developing new biomaterials [16][17][18][19][20], on enzyme modification [21][22][23][24][25][26][27], enzyme immobilisation methods [28][29][30][31][32][33][34], and enzyme electrode structures [35] have been reported in the literature in an effort to improve the performance of enzyme electrodes.…”

Section: Open Accessmentioning

confidence: 99%

“…Biopolymers based on phospholipid polymer mimicking the cell membrane were developed. Those polymers have good biocompatibility, and inhibit the adhesion and activation of blood cells, thus minimises blood coagulation when contacts blood [17,19,90]. Feasibility of introducing redox property to phospholipid polymers was investigated.…”

Section: Sem Afmmentioning

confidence: 99%

Enzymatic Biofuel Cells—Fabrication of Enzyme Electrodes

Scott

2010

Energies

130

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Enzyme based bioelectronics have attracted increasing interest in recent years because of their applications on biomedical research and healthcare. They also have broad applications in environmental monitoring, and as the power source for portable electronic devices. In this review, the technology developed for fabrication of enzyme electrodes has been described. Different enzyme immobilisation methods using layered structures with self-assembled monolayers (SAM) and entrapment of enzymes in polymer matrixes have been reviewed. The performances of enzymatic biofuel cells are summarised. Various approaches on further development to overcome the current challenges have been discussed. This innovative technology will have a major impact and benefit medical science and clinical research, healthcare management, energy production from renewable sources.

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Hemocompatibility of human whole blood on polymers with a phospholipid polar group and its mechanism

Cited by 437 publications

References 10 publications

Surface and Interface Analyses of Polymer Brushes by Synchrotron Radiation

Surface and Interface Analyses of Polymer Brushes by Synchrotron Radiation

Proteins at Interfaces

Enzymatic Biofuel Cells—Fabrication of Enzyme Electrodes

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