Hemocompatible surface of electrospun nanofibrous scaffolds by ATRP modification

Yuan, Wenjie; Feng, Yakai; Wang, Heyun; Yang, Di; An, Bo; Zhang, Wencheng; Khan, Musammir; Guo, Jintang

doi:10.1016/j.msec.2013.04.048

Cited by 77 publications

(52 citation statements)

References 33 publications

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“…In general, hydrophilic surfaces provide good lubricity while surface hydrophobicity can lead to thrombogenesis arising from preferred fibrinogen adsorption activating adhesion of platelets and clotting [48]. In order to explain the time course of friction behaviour, the hydrophilicity of the chitosan coatings was characterized by measurement of the water contact angle every second for a period of 60 seconds.…”

Section: Surface Wettabilitymentioning

confidence: 99%

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Niemczyk

Fray

Franklin

2015

Tribology International

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The friction behaviour of new chitosan derivative coatings obtained by chemical modification of chitosan with fatty acids (linoleic and dilinoleic acid) has been investigated in order to explore their potential as endovascular catheter coatings and to benchmark them against commercially available coatings used in endovascular catheter applications. An in vitro tribological system was developed that was intended to represent to a limited extent the in vivo tribological conditions of a typical endovascular catheterization procedure. Continuous reciprocating sliding tests were carried out with uncoated and coated polymer specimens. The results showed that all of the coatings tested decreased the coefficient of friction compared to the uncoated polymer. Compared to a neat chitosan coating, the chitosan derivative coatings showed a clear reduction in the coefficient of friction to levels similar to those of the commercially-available coatings. A comparison between the friction results and contact angle measurements carried out on the coatings indicated that a range of contact angle values exists for which the friction coefficient is at a minimum. The reason for this is unclear and further studies are required in order to confirm and investigate the trend, especially within the context of hydrophilic lubricious coating development.

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Section: Surface Wettabilitymentioning

confidence: 99%

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Niemczyk

Fray

Franklin

2015

Tribology International

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“…39 It was recently applied in the evaluation of the in vitro antithrombogenicity of biomaterials. 40,41 The aPTT of pure PLGA and E-PLGA nanofiber membranes are presented in Figure 4B. The aPTT of E-PLGA membranes was significantly (P0.05) prolonged as compared to that of pure PLGA equivalents.…”

Section: In Vitro Antioxidant Activity and Hemocompatibilitymentioning

confidence: 99%

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Shin¹,

Yang²,

Lee³

et al. 2014

IJN

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This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic- co -glycolic acid) (PLGA) loaded with epigallocatechin-3- O -gallate (EGCG), the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA) nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in both scavenging reactive oxygen species and extending activated partial thromboplastin time. Macroscopic observation after 1 week of surgical treatment revealed that the antiadhesion efficacy of E-PLGA nanofiber membranes was significantly superior to those of untreated controls and pure PLGA equivalents, which was comparable to that of a commercial tissue-adhesion barrier. In conclusion, the E-PLGA hybrid nanofiber can be exploited to craft strategies for the prevention of postsurgical adhesions.

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“…It was further incubated in 50 µL of platelet-poor plasma at 37°C for 1 minute, then 50 µL of NaCl-thromboplastin reagent (Factor III) was added and gently stirred with a sterile steel needle until clot formation. 30 …”

Section: Pt Assaymentioning

confidence: 99%

“…However, the rupturing phenomenon is also reported during contact with foreign substances due to excessive osmotic stress exerted from the incompatible material surface. 63 The adenosine diphosphate released by the damaged RBCs is reported to intensify the attraction and assembly of platelets towards the material surface. This, in turn, may speed up the triggering of coagulation cascades and thrombosis, 58,63 eventually disturbing the wound healing cycle.…”

Section: Determination Of Hemolytic Indexmentioning

confidence: 99%

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Balaji

Jaganathan

Ismail

et al. 2016

IJN

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Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4–50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries.

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Hemocompatible surface of electrospun nanofibrous scaffolds by ATRP modification

Cited by 77 publications

References 33 publications

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Friction behaviour of hydrophilic lubricious coatings for medical device applications

PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

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