Hemodiafiltración con reinfusión endógena del ultrafiltrado (HFR): hacia una diálisis convectiva, difusiva y adsortiva

Blood Purification for the Treatment of Chronic Kidney Disease-associated Pruritus

“…This regenerated ultrafiltrate deprived of toxins is used as a replacement fluid in a third component: a low-flux polyethersulfone membrane (1.7 m 2 , Kuf 13 mL/h/mmHg) for the traditional dialysis process where diffusion and net ultrafiltration take place. [60] Compared to HDF, HFR allows the removal of large toxins by convection and protein-bound toxins by adsorption but also the reinfusion of various important physiological compounds such as amino acids. [61,62] Moreover, slower ultrafiltration flux allows longer contact with the resin without the problems related di biocompatibility because there's no direct contact between blood and the sorbent cartridge.…”

“…[77] Main features of each treatment with potential disadvantages are summarised in Table 1. [84][85][86] CONCLUSION CKD-aP is a prevalent and disruptive condition that affect patients on maintenance hemodialysis with strong impact on their quality of life and long-term prognosis. Even if the pathogenesis is not well-understood, this clinical manifestation reflects, the current limitation of conventional membranes for the removal of toxins that not only are associated the generation of pruritus but also increase morbidity and mortality of maintenance hemodialysis patients.…”

“…This regenerated ultrafiltrate deprived of toxins is used as a replacement fluid in a third component: a low-flux polyethersulfone membrane (1.7 m 2 , Kuf 13 mL/h/mmHg) for the traditional dialysis process where diffusion and net ultrafiltration take place. [60]…”