Hemodialysis catheter colonised by Pandoraea spotorum

Monzón, Tania; Valga, Francisco; Reichert, Jorge; López, C.

doi:10.1016/j.nefroe.2018.06.013

Cited by 5 publications

(9 citation statements)

References 5 publications

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“…Seldom, from non-CF patients, has also been reported [ Table 1 ]. [ 3 , 6 - 8 , 10 , 11 , 14 , 15 ] The growth of organism from blood and urine samples indicates their potential to invade lung epithelial cells. However, the ability to invade lung epithelial cells is not common and is unlikely to be the major virulence factor of these strains.…”

Section: Discussionmentioning

confidence: 99%

Skull base osteomyelitis by Pandoraea apista: An unusual pathogen at unusual location – A case report

Patil

Tripathi

Charaya³

et al. 2021

Surgical Neurology International

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Background: Pandoraea apista is predominantly recovered from the respiratory tract of patients with cystic fibrosis (CF). Authors report first case of central nervous system infection by P. apista in the form of skull base osteomyelitis. Case Description: A 67-year-old male presented with complaints of earache and hearing deficit for few months. The radiology was suggestive of skull base osteomyelitis and polypoidal soft tissue extending from the middle cranial fossa to the infratemporal fossa. The sample from the targeted area revealed P. apista on matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. With adequate antibiotic therapy, there was clinicoradiologic improvement. P. apista is an infection exclusively seen in pulmonary infection in patients with CF. We identified its intracranial involvement in a patient for the 1st time in the literature. The serendipitous diagnosis needs evaluation on specific PCR and matrix-assisted laser desorption spectrometry. The treatment with antibiotics provides a definite cure. Conclusion: We report a rare opportunistic infection with central nervous system involvement which can be cured by accurate diagnosis and appropriate antibiotic treatment.

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Section: Discussionmentioning

confidence: 99%

Skull base osteomyelitis by Pandoraea apista: An unusual pathogen at unusual location – A case report

Patil

Tripathi

Charaya³

et al. 2021

Surgical Neurology International

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“…These non-fermentative, Gram-negative bacilli (NFGNB), with oxidase activity, are naturally encountered in soil or water, but they can also be nosocomial pathogens associated with invasive devices, such as catheters or ventilation systems. [1][2][3][4][5][6] To date, six species have been identified in humans -Pandoraea apista, Pandoraea pulmonicola, Pandoraea pnomenusa, Pandoraea sputorum, Pandoraea norimbergensis and Pandoraea fibrosis. 1,6 Although rare, the Pandoraea spp.…”

Section: Introductionmentioning

confidence: 99%

“…are emerging, with most isolates originating from sputum samples of patients with CF or other lung diseases. [2][3][4]7,8 In addition to respiratory samples, isolation in skin lesions, urine and blood have been described in CF and non-CF patients, the latter highlighting the invasive capacity of this species. 2,4,9,10 P. pnomenusa was the most isolated species from blood cultures (BC) in a Centers for Disease Control and Prevention study of 2001, 2 which revealed an increased potential for invasive disease.…”

Section: Introductionmentioning

confidence: 99%

“…5,[8][9][10][11] Catheter-related bloodstream infections (CR-BSI) and colonization of catheters without bacteriemia were also reported. 3,12 Phenotypically, Pandoraea spp. are very similar to Burkholderia and Ralstonia genera (with an intermediate phylogenetic position between these two), which may lead to an erroneous phenotypic identification of these agents.…”

Section: Introductionmentioning

confidence: 99%

“…are very similar to Burkholderia and Ralstonia genera (with an intermediate phylogenetic position between these two), which may lead to an erroneous phenotypic identification of these agents. [1][2][3][4][5]8,10 In fact, the incidence of Pandoraea infections may be underestimated due to difficulties in its identification. However, mass spectrometry assays have proven to be able to identify NFGNB which were not correctly identified by phenotypic methods.…”

Section: Introductionmentioning

confidence: 99%

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Fever in a Patient with a Central Venous Catheter Colonized by Pandoraea pnomenusa

et al. 2022

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Pandoraea species are a newly described genus of multidrug-resistant, non-fermentative Gram-negative bacilli, mainly isolated from sputum samples of cystic fibrosis patients. In immunocompromised patients or with high antibiotic selective pressure, these pathogens are generally opportunistic and invasive. Although Pandoraea spp. are rare, the true incidence of these infections may be underestimated due to difficulties in microbial identification by phenotypic methods. We present the case of a 51-year-old woman, with new-onset fever after a prolonged hospitalization and multiple courses of antibiotics. Mass spectrometry assays identified Pandoraea pnomenusa in the blood cultures taken from the central venous catheter and in the catheter tip. Fever cessation after catheter removal suggests a catheter-related bloodstream infection. To the best of our knowledge, this is the first isolation of a Pandoraea spp. in Portugal, which should raise awareness to the emergence of these opportunistic and multidrug-resistant microorganisms, and the importance of its prompt identification.

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Sepsis Due to Pandoraea sputorum Infection After Multiple Trauma in a Non-Cystic Fibrosis Patient: A Case Report from Southeast China

Ma¹,

Zou²,

Lin³

et al. 2022

IDR

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Pandoraea sputorum ( P. sputorum ) infection is of great concern as these gram-negative bacillus species are multidrug-resistant and usually isolated from the patients’ respiratory tract suffering from cystic fibrosis (CF). A few cases of infection have also been reported in non-CF patients due to its rare pathogenic nature with unclear and overlapping clinical, biochemical, and microbiological characteristics with other species. Here, we report an unusual case of a 46-year-old non-CF female, who presented with multiple pelvic fractures, acute traumatic brain injury, multiple rib fractures, and multiple burns (18% of the total body surface area, II°) by the collapse of a brick kiln, suffered from P. sputorum sepsis due to wound infection. Pandoraea species were isolated both from her blood and wound secretion. Antibiotic susceptibility testing indicated susceptibility to imipenem, tetracyclines, sulfamethoxazole, and ampicillin/sulbactam but resistance to meropenem, quinolones, aminoglycosides, and other beta-lactams. 16S ribosomal RNA (rRNA) PCR assays and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to confirm the bacteria as P. sputorum . After effective anti-infection of intravenous antibiotics (imipenem 1.0 Q8H with tigecycline 50 mg Q12H for 14 days), wound care, and other comprehensive treatment for two months, the patient improved and was discharged from the hospital eventually. After reviewing the literature, we observed that the susceptibility results of Pandoraea species were often multidrug-resistant and had a unique pattern of being resistant to meropenem but sensitive to imipenem. Biofilm formation, carbapenemase production, and unique gene procession differed from the environmental isolates could help explain its resistance. This case report highlights the potential virulence of Pandoraea species as a pathogen in patients with no underlying disease. Although they are often multi-resistant, imipenem can be a preferred treatment for Pandoraea species in the earliest identification steps.

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Hemodialysis catheter colonised by Pandoraea spotorum

Cited by 5 publications

References 5 publications

Skull base osteomyelitis by Pandoraea apista: An unusual pathogen at unusual location – A case report

Skull base osteomyelitis by Pandoraea apista: An unusual pathogen at unusual location – A case report

Fever in a Patient with a Central Venous Catheter Colonized by Pandoraea pnomenusa

Sepsis Due to Pandoraea sputorum Infection After Multiple Trauma in a Non-Cystic Fibrosis Patient: A Case Report from Southeast China

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