Hemodynamic Alterations in Diabetic Retinopathy

Güven, Dilek; Özdemi̇r, Hakan; Hasanreısoğlu, Berati

doi:10.1016/s0161-6420(96)30514-9

Cited by 64 publications

(66 citation statements)

References 16 publications

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“…These studies focused only on some of the orbital vessels and measured indices and velocities in specific diabetic or control groups. They were usually of limited sample size, and the results produced were inconsistent [3][4][5][6][7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…However, the role of hemodynamics in DR has not been clearly defined [2]. There have also been conflicting reports of impaired hemodynamics in the orbital vessels in patients with DR [3][4][5][6][7][8][9][10][11][12][13][14]. Orbital blood flow velocities were increased in some studies [3], but decreased in others [4, 9-11, 13, 14], or unchanged [15].…”

Section: Introductionmentioning

confidence: 99%

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Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

Karami

Janghorbani²,

Dehghani³

et al. 2012

Rev Diabet Stud

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■ Abstract BACKGROUND:There have been conflicting results in relation to impaired ocular hemodynamics in the orbital vessels of patients with diabetic retinopathy (DR). Clarification of the early signs of retinopathy in diabetic patients is urgently needed. AIMS: We aimed to evaluate orbital blood flow velocities using Doppler and gray-scale sonography in patients with DR, and to compare the results with those of their non-diabetic and diabetic peers without retinopathy. METHODS: Orbital Doppler and gray-scale sonography were performed in 123 patients aged 29-77 who had been divided into 3 groups: non-diabetic controls (n = 25), diabetes and impaired glucose tolerance with minimal clinical retinopathy (n = 74), and diabetes with untreated nonproliferative retinopathy (n = 24). Retinopathy was diagnosed by an ophthalmologist on the basis of fundoscopic examination. The peak systolic (PSV) and end-diastolic (EDV) blood flow velocities, and the resistivity and pulsatile indices, of the ophthalmic artery, central retinal artery, posterior ciliary artery, and central retinal vein were measured. RE-SULTS: Compared with healthy controls, the age-adjusted resistivity and pulsatile indices of the ophthalmic artery were significantly higher in patients with DR (p < 0.05). PSV and EDV of the posterior ciliary arteries were significantly lower in diabetic patients with DR. After further adjustment for age, gender, HbA1c, fasting plasma glucose, blood pressure, BMI, cholesterol, HDL, LDL, and triglycerides, only the resistivity index of the ophthalmic artery and the central retinal vein remained significantly higher in patients with DR compared with healthy controls (p < 0.005 after Bonferroni adjustment). CONCLUSIONS: Resistivity index alteration of the ophthalmic artery and central retinal vein may be prevalent among patients with early changes in DR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

Karami

Janghorbani²,

Dehghani³

et al. 2012

Rev Diabet Stud

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“…Studies of retrobulbar hemodynamics of the central retinal artery (CRA), short posterior ciliary artery (PCA) and OA in diabetic patients with diabetic retinopathy have already been performed (Goebel et al 1995;Guven et al 1996). Measurements have demonstrated a correlation between severity of diabetic retinopathy and decreased flow velocity in the CRA, but not in PCA or OA.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic artery blood flow velocity changes in diabetic patients as a manifestation of macroangiopathy

Inoue

Azumi

Yamamoto

2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The hemodynamic characteristics of ophthalmic artery (OA) blood flow velocity in diabetic patients with ocular involvement were evaluated. Methods: Changes in OA blood flow of eyes with background diabetic retinopathy (BDR), proliferative retinopathy (PDR) and ocular ischemic syndrome (OIS) were ananalyzed by Color Doppler imaging. Results: Patients with BDR and PDR had significantly lower diastolic and mean blood flow velocities and higher pulsatility indices compared to controls. Diabetic patients with OIS had significantly lower systolic, diastolic and mean anterograde OA blood flow velocities than the controls. Pulsatility indices were higher in anterograde OA blood flow measurements compared to controls. Systolic blood flow velocities in rubeotic eyes with OIS were significantly lower than in rubeotic eyes with PDR. Conclusion: OA blood flow measurements by color doppler imaging may detect macroangiopathies in diabetic patients as manifested by carotid atheromas and arterio-and arterosclerosis of the OA and its branches.

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“…Color Doppler ultrasonography is a noninvasive method that is often shown to be useful in evaluating blood flow velocities in orbital and retinal vascular diseases (Hu et al 1993;Gü ven et al 1996). The aim of this study was to detect prospectively the value of duplex and color Doppler imaging of orbital vasculature in patients with Behçet's disease.…”

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confidence: 99%

Color Doppler ultrasonography in ocular Behçet's disease

Çelebi¹,

Akfirat²,

Çelebi

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The aim of this prospective study was to assess the ocular hemodynamic changes in patients with Behçet's disease who had involvement of the posterior segment by color Doppler ultrasonography. Methods: The present study was carried out in 32 eyes of 24 patients with ocular Behçet's disease and 42 eyes of 21 persons as a healthy age-matched control group. In order to detect the hemodynamic changes in ocular Behçet's disease, peak systolic and end-diastolic velocities (PSV, EDV; cm/sec), resistive and pulsatile indices (RI, PI), and PSV/EDV ratio of central retinal artery (CRA), short posterior ciliary artery (PCA) and ophthalmic artery (OA) were determined. Results: The mean PSV and EDV (8.1∫2.6 and 2.7∫0.1 cm/sec, respectively) in the CRA were significantly lower in patients with Behçet's disease than in healthy controls (11.5∫2.2 and 3.5∫1.0 cm/sec, respectively, p∞0.001). For the PCA, these values (12.7∫4.2 and 4.3∫1.1 cm/sec, respectively) were significantly lower in the patient group than in the control the group (18.2∫4.2 and 6.1∫2.5 cm/sec, respectively, p∞0.001). In the patient group, a statistically significant decrease compared to the control group was detected in the mean PSV of the OA (31.8∫8.2 and 35.8∫0.6 cm/sec, respectively, p∞0.02). However, no significant difference in the other parameters of these vessels was observed between groups.Conclusions: These results demonstrate the presence of some circulatory changes in the flow velocities of the CRA, PCA and OA in patients with Behçet's disease when compared with control subjects.

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Hemodynamic Alterations in Diabetic Retinopathy

Cited by 64 publications

References 16 publications

Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

Orbital Doppler Evaluation of Blood Flow Velocities in Patients with Diabetic Retinopathy

Ophthalmic artery blood flow velocity changes in diabetic patients as a manifestation of macroangiopathy

Color Doppler ultrasonography in ocular Behçet's disease

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