Hemodynamic analysis of blood flow in umbilical artery using computational modeling

Shah, Ruchit; Girardi, Theresa; Merz, George; Necaise, Phillip; Salafia, Carolyn M.

doi:10.1016/j.placenta.2017.05.017

Cited by 13 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the 3D published models (n = 5) used similar geometry and blood model, but had differences in their inflow velocity and pressure values ( Table 2 ). The up to date studies were focused either on the investigation of the variations of WSS and blood flow [ 20 , 32 – 34 ] or on how knots and notching affect blood flow in UAs [ 22 , 31 ]. Most of the included studies modeled only the UAs and usually just one UA.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the increase in transdisciplinary collaborations between engineers and clinicians and the advances in FEA during the last ten years [22,[31][32][33][34], have resulted in the first computational models of the UC. These models are still limited, as they have generally been focused on the study of a single UA only, examining mainly the effects of the coiled structure on the pressure gradients and the influence of knots in the blood flow [20,22,[31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

“…The direct comparison of our results with the five studies, obtained from our literature search ( Table 2 ) is not applicable due to significant differences in methodologies, geometries and characteristics. Most of the existing studies were focused on the characterisation of the WSS [ 20 , 32 , 34 ], while the scope of our study was to investigate maternal-fetal heat transfer. Velocity profiles of our study revealed similar behaviour with the results presented by other studies where high velocity, which was observed near the centre, skewed towards the outside wall [ 31 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…For the purpose of our model, in all simulations the blood flow inside both the UV and UAs was considered as steady, laminar and incompressible. No slip boundary conditions were applied at the vascular walls [ 20 ]. During the simulation the mass and momentum conservation equation was used written in the general form …”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord

2020

View full text Add to dashboard Cite

Human fetal thermoregulation, maternal-fetal heat exchange, and the role of the umbilical cord in these processes are not well understood. Ethical and technical limitations have restricted current knowledge to animal studies, that do not reflect human morphology. Here, we present the first 3-dimensional computational model of the human umbilical cord with finite element analysis, aiming to compute the maternal-fetal heat exchange. By modelling both the umbilical vein and the two umbilical arteries, we found that the coiled geometry of the umbilical artery, in comparison with the primarily straight umbilical vein, affects blood flow parameters such as velocity, pressure, temperature, shear strain rate and static entropy. Specifically, by enhancing the heat transfer coefficient, we have shown that the helical structure of the umbilical arteries plays a vital role in the temperature drop of the blood, along the arterial length from the fetal end to the placental end. This suggests the importance of the umbilical cord structure in maternal-fetal heat exchange and fetal heat loss, opening the way for future research with modified models and scenarios, as the basis for early detection of potential heat-transfer related complications, and/or assurance of fetal wellbeing.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord

2020

View full text Add to dashboard Cite

show abstract

“…While it originated in the aerospace industry, the increasing range and sophistication of models as well as the increased availability of high‐performance computing has broadened the application of CFD to other areas, including medical applications. Examples of this include modeling airflow and aerosols in the throat and lungs, blood flow for cardiovascular applications, and modeling of the stomach and intestine . Modeling approaches like CFD are advantageous in that they can reduce the need for experimental research, which can be costly, complex, and ethically challenging.…”

Section: In Silico Mathematical and Computational Modelsmentioning

confidence: 99%

Models of the Gut for Analyzing the Impact of Food and Drugs

Fois

Schindeler

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

The human intestine is the primary organ responsible for the uptake of nutrients and water, and this is facilitated by its complex structure that features a large surface area. With an average total length of around seven meters, including both small and large intestine, it connects the stomach to the rectum while enabling absorption in a specialized manner. At a cellular level, the gut epithelium is critical in selective transport to the bloodstream. The finger-like projections of the intestinal epithelium Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.

show abstract

Personalising cardiovascular network models in pregnancy: A two‐tiered parameter estimation approach

Carson

Warrander

Johnstone

et al. 2020

Numer Methods Biomed Eng

View full text Add to dashboard Cite

Uterine artery Doppler waveforms are often studied to determine whether a patient is at risk of developing pathologies such as pre‐eclampsia. Many uterine waveform indices have been developed, which attempt to relate characteristics of the waveform with the physiological adaptation of the maternal cardiovascular system, and are often suggested to be an indicator of increased placenta resistance and arterial stiffness. Doppler waveforms of four patients, two of whom developed pre‐eclampsia, are compared with a comprehensive closed‐loop model of pregnancy. The closed‐loop model has been previously validated but has been extended to include an improved parameter estimation technique that utilises systolic and diastolic blood pressure, cardiac output, heart rate, and pulse wave velocity measurements to adapt model resistances, compliances, blood volume, and the mean vessel areas in the main systemic arteries. The shape of the model‐predicted uterine artery velocity waveforms showed good agreement with the characteristics observed in the patient Doppler waveforms. The personalised models obtained now allow a prediction of the uterine pressure waveforms in addition to the uterine velocity. This allows for a more detailed mechanistic analysis of the waveforms, eg, wave intensity analysis, to study existing clinical indices. The findings indicate that to accurately estimate arterial stiffness, both pulse pressure and pulse wave velocities are required. In addition, the results predict that patients who developed pre‐eclampsia later in pregnancy have larger vessel areas in the main systemic arteries compared with the two patients who had normal pregnancy outcomes.

show abstract

Hemodynamic analysis of blood flow in umbilical artery using computational modeling

Cited by 13 publications

References 21 publications

A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord

A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord

Models of the Gut for Analyzing the Impact of Food and Drugs

Personalising cardiovascular network models in pregnancy: A two‐tiered parameter estimation approach

Contact Info

Product

Resources

About