Hemodynamic analysis of patient‐specific coronary artery tree

Zhang, Junmei; Luo, Tong; Tan, Swee Yaw; Lomarda, Aileen Mae; Wong, Aaron; Keng, Felix; Allen, John C.; Huo, Yunlong; Su, Boyang; Zhao, Xiaodan; Wan, Min; Kassab, Ghassan S.; Tan, Ru San; Zhong, Liang

doi:10.1002/cnm.2708

Cited by 41 publications

(26 citation statements)

References 46 publications

(67 reference statements)

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“…Obviously, the arteries with the lower values of FFR, iFR, and CFR than the related cut-off values mentioned in the literature have a higher potential for significant coronary stenosis. The hemodynamic parameters, wall shear stress (WSS), OSI, TAWSS, and RRT, are calculated by the following formulas 56 :…”

Section: Analysis Of Resultsmentioning

confidence: 99%

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific computational models

Tajeddini

Nikmaneshi

Firoozabadi

et al. 2020

Numer Methods Biomed Eng

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The objective of this paper is to apply computational fluid dynamic (CFD) as a complementary tool for clinical tests to not only predict the present and future status of left coronary artery stenosis but also to evaluate some clinical hypotheses. In order to assess the present status of the coronary artery stenosis severity, and thereby selecting the most appropriate type of treatment for each patient, fractional flow reserve (FFR), instantaneous wave free-ratio (iFR), and coronary flow reserve (CFR) are calculated. To examine FFR, iFR, and CFR results, the effect of geometric features of stenoses, including diameter reduction (%), lesion length (LL), and minimum lumen diameter (MLD), is studied on them. It is observed that FFR is a more conservative index than iFR and CFR to assess the severity of coronary stenosis. In addition, it is seen that FFR, iFR, and CFR decrease by increasing LL and decreasing MLD. Therefore, the morphological indices, LL/MLD and LL/MLD^4, with the calculated conservative cutoff values equal to 5.5 and 3.6, are considered. Next, some controversial clinical hypotheses about the assessment of the severity of coronary stenosis are evaluated numerically. These include the examination of FFR, iFR, and CFR accuracies, investigating the effect of coronary hyperemia on iFR, as well as the reliability of the hybrid iFR-FFR decision-making strategy. The presented numerical model can also be used as a predictive tool to identify the atherosuseptible sites of arteries by calculating the time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT).

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Section: Analysis Of Resultsmentioning

confidence: 99%

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific computational models

Tajeddini

Nikmaneshi

Firoozabadi

et al. 2020

Numer Methods Biomed Eng

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“…There exist two options for computation of the virtual FFR. The first option uses the 3D or 2D model of blood flow in the local region of the studied vessel [16,38,73,121,135,159,163,187] and suffers the bad posedness of upstream and downstream boundary conditions, rigid wall approximation for the vessel wall, high computational cost, local region for computational domain, difficulties in determining patient-specific parameters [140,181]. The recent trend is the use of machine learning tools for replacement of costly 3D simulations [45].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Mathematical modelling of atherosclerosis

Khatib¹,

Kafi²,

Sequeira³

et al. 2019

Math. Model. Nat. Phenom.

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The review presents the state of the art in the atherosclerosis modelling. It begins with the biological introduction describing the mechanisms of chronic inflammation of artery walls characterizing the development of atherosclerosis. In particular, we present in more detail models describing this chronic inflammation as a reaction-diffusion wave with regimes of propagation depending on the level of cholesterol (LDL) and models of rolling monocytes initializing the inflammation. Further development of this disease results in the formation of atherosclerotic plaque, vessel remodelling and possible plaque rupture due its interaction with blood flow. We review plaque-flow interaction models as well as reduced models (0D and 1D) of blood flow in atherosclerotic vasculature.

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“…The arterial system is represented by a network of elastic tubes, with the LV as the inlet of the circuit and peripheral circulation as terminals. Some relevant contributions on 1D blood flow modelling can be found in recent studies …”

Section: Modelling the Effects Of Ageing On The Human Bodymentioning

confidence: 99%

“…Some relevant contributions on 1D blood flow modelling can be found in recent studies. [46][47][48][49][50][51][52][53][54][55][56][57]…”

Section: Arterial Systemmentioning

confidence: 99%

Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study

Coccarelli

Hasan

Carson

et al. 2018

Numer Methods Biomed Eng

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Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced changes. The study outlines a framework for age‐related modifications within several interlinked subsystems, which include arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration. Some of the proposed age‐dependent governing equations are directly extrapolated from experimental data sets. The computational framework is demonstrated through numerical experiments, which show the impact of such age‐related changes on arterial blood pressure, local temperature distribution, and global body thermal response. The proposed numerical experiments show that the age‐related changes in arterial convection do not significantly affect the tissue temperature distribution. Results also highlight age‐related effects on the sweating mechanism, which lead to a significant reduction in heat dissipation and a subsequent rise in skin and core temperatures.

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Hemodynamic analysis of patient‐specific coronary artery tree

Cited by 41 publications

References 46 publications

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific computational models

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific computational models

Mathematical modelling of atherosclerosis

Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study

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