Hemodynamic and Electrocardiographic Effects of Disopyramide in Patients with Ventricular Arrhythmia

Abstract

Antiarrhythmic and hemodynamic effects of i.v. disopyramide phosphate (1.7 mg/kg b.wt. Acta med. scand. 1W 4-752981 Acla med. scand. I99

Kinetics of Hemodynamic and Electrocardiographic Changes Following Intravenous Disopyramide

“…A prolongation of PEP (or PEPILVET), which can be measured by non-invasive techniques, appeared to be a more sensitive measure of reduced cardiac contractility than a change in DPAP. On the other hand, the largest changes in PEP were seen in patients with high initial DPAP values (8). PEP showed a linear relationship to disopyramide concentration.…”

“…Nine patients with persistent ventricular arrhythmias were studied. The patients and the experimental procedure have been presented in a previous study (8). Individual characteristics and basal hemodynamic findings are given in Table I.…”

“…Disopyramide (DurbiP) is an antiarrhythmic drug that effectively suppresses ventricular ectopic activity after i.v. or oral administration (7,8,15,21). Electrophysiological studies in man have shown a prolongation of the refractory period of the left ventricle (19) and an increase in the His-hrkinje conduction time (12).…”

“…The effect on the resting ECG seems to vary; there is little effect on the normal heart (14), whereas in heart disease a prolongation of ECG time intervals may occur after i.v. or oral administration (7,8,15). The drug has a negative inotropic effect, which may be of clinical significance (8, 10).…”

Disopyramide in Ventricular Tachycardia

“…During the haemodynamic study with ventricular tachycardia, there were transient, moderate prolongations of the QRS intervals, which were of the same order of magnitude and duration as in a previous study on the effect of i.v. DE in patients in sinus rhythm and with ventricular ectopic beats (1). When sinus rhythm had been established 60 min after the second injection of DE, the PQ, QRS and Q T intervals were all within normal limits and not significantly different from the corresponding intervals of the patient's previous ECGs before ventricular tachycardia had occurred and DE had been given (Fig.…”