Hemodynamic and Metabolic Changes During Myocardial Ischemia

Possible mechanisms of action of oxyfedrine as an antianginal drug [letter]

“…However, it would we think be a major contribution to the clinical pharmacology of this fascinating compound if studies were performed in which left ventricular end-diastolic pressure and volume were measured, preferably together with myocardial lactate extraction/production data, during angina induced by electrical pacing or by exercise (e.g. Parker, 1972). Another intriguing question which requires answering is whether, following prolonged administration of oxyfedrine to anginal patients, it loses its agonist properties whilst retaining its antagonist properties at f3-adrenoceptor sites.…”

Acute cardiogenic pulmonary edema

“…This increase incidence of silent ischemia, however, was not too surprising in view of the advanced age and the high incidence of diabetes which are two conditions known to be associated with this presentation. Silent as well as symptomatic myocardial ischemia very frequently produce an increase in left ventricular enddiastolic and capillary pulmonary pressures [20][21][22][23] which eventually lead to APE. This abnormal capillary pressure is further increased by a reactive increase in systemic arterial pressure that may worsen pulmonary congestion [22][23][24].…”