Hemodynamic and metabolic effects of decompressive hemicraniectomy in normal brain

Schaller, Bernhard; Graf, Rudolf; Sanada, Yasuhiro; Rösner, Gerhard; Wienhard, K.; Heiss, Wolf‐Dieter

doi:10.1016/s0006-8993(03)02900-7

Cited by 79 publications

(45 citation statements)

References 22 publications

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“…It seems clear that a decline in tumor tissue uptake of 18F-FDG weeks or months after therapy is suggestive of a good response to treatment, indicating either a reduced number of viable cells or reduced metabolism of damaged cells (16,103).…”

Section: Evaluation Of Therapy By Petmentioning

confidence: 99%

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sandu

Pöpperl²,

Toubert

et al. 2011

Mol Med

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Energy metabolism measurements in spinal cord tumors, as well as in osseous spinal tumors/metastasis in vivo, are rarely performed only with molecular imaging (MI) by positron emission tomography (PET). This imaging modality developed from a small number of basic clinical science investigations followed by subsequent work that influenced and enhanced the research of others. Apart from precise anatomical localization by coregistration of morphological imaging and quantification, the most intriguing advantage of this imaging is the opportunity to investigate the time course (dynamics) of disease-specific molecular events in the intact organism. Most importantly, MI represents one of the key technologies in translational molecular neuroscience research, helping to develop experimental protocols that may later be applied to human patients. PET may help monitor a patient at the vertebral level after surgery and during adjuvant treatment for recurrent or progressive disease. Common clinical indications for MI of primary or secondary CNS spinal tumors are: (i) tumor diagnosis, (ii) identification of the metabolically active tumor compartments (differentiation of viable tumor tissue from necrosis) and (iii) prediction of treatment response by measurement of tumor perfusion or ischemia. While spinal PET has been used under specific circumstances, a question remains as to whether the magnitude of biochemical alterations observed by MI in CNS tumors in general (specifically spinal tumors) can reveal any prognostic value with respect to survival. MI may be able to better identify early disease and to differentiate benign from malignant lesions than more traditional methods. Moreover, an adequate identification of treatment effectiveness may influence patient management. MI probes could be developed to image the function of targets without disturbing them or as treatment to modify the target's function. MI therefore closes the gap between in vitro and in vivo integrative biology of disease. At the spinal level, MI may help to detect progression or recurrence of metastatic disease after surgical treatment. In cases of nonsurgical treatments such as chemo-, hormone-or radiotherapy, it may better assess biological efficiency than conventional imaging modalities coupled with blood tumor markers. In fact, PET provides a unique possibility to correlate topography and specific metabolic activity, but it requires additional clinical and experimental experience and research to find new indications for primary or secondary spinal tumors.

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Section: Evaluation Of Therapy By Petmentioning

confidence: 99%

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sandu

Pöpperl²,

Toubert

et al. 2011

Mol Med

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“…[5][6][7] Given the importance of small animal models such as mice and rats to many research fields, the development of noninvasive measurement methods to assess oxygen metabolism in small animals is needed.…”

Section: Introductionmentioning

confidence: 99%

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of ¹⁵O-gas in mice with bilateral common carotid artery stenosis

Temma

Yamazaki

Miyanohara

et al. 2017

J Cereb Blood Flow Metab

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15 O-gas with isoflurane was supplied to the nose of mouse with evacuation of excess 15 O-gas surrounding the body. 15 O-PET was performed on days 3, 7, 14, 21, and 28 after surgery. Cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO 2 ) were calculated in whole brains. A significant decrease in CBF and compensatory increase in OEF in the BCAS group produced CMRO 2 values comparable to that of the sham group at three days post-operation. Although CBF and OEF in the BCAS group gradually recovered over the first 28 days, the CMRO 2 showed a gradual decrease to 68% of sham values at 28 days post-operation. In conclusion, we successfully developed a noninvasive 15 O-PET method for mice.

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“…Commonly, as for RICH in which the non-operative management is ineffective, wide decompressive craniectomy may have an impact on reducing ICP by allowing expansion of edematous brain tissue away from the lateral ventricle, the diencephalon, and mesencephalon by removing portions of the osseous skull 8,16,22) . However, the kinds of complications may follow the operation such as skin flap concavity or convexity (the herniation of brain through craniectomy site), EDH, SDF, and hydrocephalus which are disadvantageous to the recover of the patient's neurological function.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Outcomes between Shunting after Cranioplasty and in Cranioplasty after Shunting in Large Concave Flaccid Cranial Defect with Hydrocephalus

Park

Cha

et al. 2008

J Korean Neurosurg Soc

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Hemodynamic and metabolic effects of decompressive hemicraniectomy in normal brain

Cited by 79 publications

References 22 publications

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of ¹⁵O-gas in mice with bilateral common carotid artery stenosis

Comparative Study of Outcomes between Shunting after Cranioplasty and in Cranioplasty after Shunting in Large Concave Flaccid Cranial Defect with Hydrocephalus

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Hemodynamic and metabolic effects of decompressive hemicraniectomy in normal brain

Cited by 79 publications

References 22 publications

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Current Molecular Imaging of Spinal Tumors in Clinical Practice

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis

Comparative Study of Outcomes between Shunting after Cranioplasty and in Cranioplasty after Shunting in Large Concave Flaccid Cranial Defect with Hydrocephalus

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Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of ¹⁵O-gas in mice with bilateral common carotid artery stenosis