Hemodynamic and Metabolic Effects of Two Anesthetic Techniques in Children Undergoing Surgical Repair of Acyanotic Congenital Heart Disease

Morgan, Philip; Lynn, Anne M; Parrot, Carol; Morray, Jeffrey P.

doi:10.1213/00000539-198710000-00023

Cited by 9 publications

(2 citation statements)

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“…92 An opioid anesthetic was associated with a lower perioperative mortality in infants compared with halothane. 87 Shorter-acting agents such as alfentanil have some appeal, especially in noncardiac situations, for use as maintenance anesthetics, but there are some drawbacks. 93 The advantages of fentanyl for patients with CHD include minimal effect on pulmonary and systemic circulations and attenuation of response to intubation and incision.…”

Section: A N E S T H E S I a A N D U N C O M M O N D I S E A S E Smentioning

confidence: 99%

Congenital Heart Disease

Oliver¹,

Lynch²

2006

Anesthesia and Uncommon Diseases

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Section: A N E S T H E S I a A N D U N C O M M O N D I S E A S E Smentioning

confidence: 99%

Congenital Heart Disease

Oliver¹,

Lynch²

2006

Anesthesia and Uncommon Diseases

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“…Comparing the isoflurane and the fentanyl groups with the respect of hemodynamic and catecholamine responses to surgical stress, isoflurane has a higher tendency of hemodymanic instability and increasing catecholamine than fentanyl. 20,21) Thirdly, the anesthetic methods, intravenous versus inhalation anesthesia, have an influence on splanchnic perfusion. The level of anesthesia could be maintained stable by continuous intravenous infusion of fentanyl during CPB.…”

Section: S5mentioning

confidence: 99%

The Comparative Effect of Fentanyl and Isoflurane on Splanchnic Perfusion during Cardiac Surgery

Hong

2003

Korean J Anesthesiol

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Background: Splanchnic perfusion derangement commonly occurs during cardiac surgery, while splanchnic ischemia is known to increase morbidity in surgical and critically ill patients. We hypothesized that anesthetic agents may have different effects on splanchnic perfusion during cardiac surgery.Methods: Twenty-four patients undergoing cardiac surgery were randomly divided into fentanyl (n = 12) and isoflurane (n = 12) groups. Gastric intramucosal PrCO2 and pHi were measured using tonometry. Patient temperature was maintained at 28 o C during cardiopulmonary bypass (CPB). Measurements were made at the following times: (1) baseline, after the induction of anesthesia, (2) 30 minutes into CPB, (3) 60 minutes into CPB, (4) at the end of CPB, ( 5) one hour after CPB, and (6) 24 hours after CPB. Statistical analysis was performed using repeated measures of ANOVA and the unpaired t-test.Results: The observed hemodynamic changes were similar in both groups. The pHi decreased significantly during hypothermic CPB and remained in this attenuated state up to 24 hours postoperatively in both groups. The pHi in the isoflurane group began to decrease at 30 minutes after starting CPB while that in the fentanyl group decreased at 60 minutes after starting CPB. The pHi of isoflurane group was significantly lower than that of the fentanyl group during CPB and 1 hour after the end of CPB. However, the pHi at 24 hours after CPB was similar in both groups.Conclusions: We conclude that fentanyl provides more protection from splanchnic ischemic insult than isoflurane during cardiac surgery with hypothermic CPB.

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The Endocrine System: Effects of Cardiopulmonary Bypass

Bannister¹,

Finlayson²

1995

Cardiopulmonary Bypass

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Hemodynamic and Metabolic Effects of Two Anesthetic Techniques in Children Undergoing Surgical Repair of Acyanotic Congenital Heart Disease

Cited by 9 publications

References 0 publications

Congenital Heart Disease

Congenital Heart Disease

The Comparative Effect of Fentanyl and Isoflurane on Splanchnic Perfusion during Cardiac Surgery

The Endocrine System: Effects of Cardiopulmonary Bypass

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