Hemodynamic changes associated with reduction in total cholesterol by treatment with the HMG-CoA reductase inhibitor pravastatin

Muramatsu, Jun; Kobayashi, A; Hasegawa, Nobuhiro; Yokouchi, Satoko

doi:10.1016/s0021-9150(96)06024-8

Cited by 72 publications

(41 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Statin treatment has been found to improve PWV among patients with hyperlipidemia 20,21) , although it has also been showen that atorvastatin increases PWV 22) , and no change in ba-PWV was observed after atorvastatin treatment in our study. These variable results may reflect the influence of many factors on PWV, including blood pressure, age and cardiovascular drugs.…”

Section: Discussioncontrasting

confidence: 66%

The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia

Ozaki

Kubo

Imaki

et al. 2006

JAT

View full text Add to dashboard Cite

We investigated the lipid lowering and anti-atherosclerotic effects of atorvastatin in patients with hypercholesterolemia. Thirty patients were given atorvastatin 10 mg daily, and assessed for serum lipids, intima-media thickness (IMT), and brachial-ankle pulse wave velocity (ba-PWV) at the baseline, 6 months, and 12 months. Remnant-like particle-cholesterol (RLP-C), lipoprotein (a) (Lp(a)), and high-sensitivity C-reactive protein (hs-CRP) were measured in some patients at the baseline and at 6 months. Total cholesterol, triglyceride and low-density lipoprotein cholesterol were significantly decreased by 32%, 23% and 44% at 6 months, respectively, and these effects were sustained at 12 months. There was no change in high-density lipoprotein cholesterol. IMT at the baseline was 0.

show abstract

Section: Discussioncontrasting

confidence: 66%

The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia

Ozaki

Kubo

Imaki

et al. 2006

JAT

View full text Add to dashboard Cite

show abstract

“…11 In addition, the long-term administration of statins has been shown to inhibit the progression of aortic stenosis 12 and to reduce aortic stiffness, as assessed by PWV, in normotensive patients with hypercholesterolaemia. 13,14 Therefore, long-term statin administration may improve BP control and PWV in patients with uncontrolled hypertension and high serum cholesterol levels. However, a recent study reported that 12-week atorvastatin treatment worsened PWV in hypertensive hyperlipidaemic patients.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of statins on arterial pressure and stiffness of hypertensives

et al. 2004

View full text Add to dashboard Cite

Although lowering blood pressure (BP) reduces aortic stiffness, achieving the recommended BP goal can be difficult. Recent studies have shown that short-term use of statins can reduce BP significantly. To determine the long-term effects of statins on BP and aortic stiffness, a single-blind randomized prospective study was performed on 85 hyperlipidaemic hypertensive patients whose BP was insufficiently controlled by antihypertensive therapy. Every 3 months, aortic stiffness was assessed by measuring pulse wave velocity (PWV). Patients were randomly allocated to groups treated with pravastatin, simvastatin, fluvastatin, or a nonstatin antihyperlipidaemic drug. No significant differences in patient characteristics, kinds of antihypertensive drugs, BP, ankle brachial index, PWV, or serum lipid, creatinine, or C-reactive protein levels were found between the four groups at the start of the study. During the 12-month treatment period, PWV did not change in the pravastatin group or nonstatin group, but it was transiently reduced in the simvastatin group and significantly decreased in the fluvastatin group, even though the doses of the statins used in this study were lower than the usually prescribed dose. All four antihyperlipidaemic drugs significantly decreased serum cholesterol levels without affecting BP, ankle brachial index, or serum triglyceride levels. The Creactive protein serum levels decreased significantly in the three statin groups but not in the nonstatin group. These results suggest that long-term use of fluvastatin by hyperlipidaemic hypertensive patients is associated with a significant reduction in aortic stiffness without any effect on BP.

show abstract

“…[10][11][12] Finally, in subjects with hypercholesterolaemia, statin treatments are associated with either decreased or unchanged alterations of arterial stiffness. 13,14 In subjects with hypertension, the situation may be even more complex to evaluate since increased stiffness may be the consequence of both high blood pressure and intrinsic modifications of the arterial wall. 3 Combined effects of hypertension and hypercholesterolaemia are known to result in a further increase of arterial stiffness, at least at the site of the radial artery.…”

Section: Introductionmentioning

confidence: 99%

Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study

Rudnichi

2002

J Hum Hypertens

View full text Add to dashboard Cite

As statins may contribute to plaque stabilisation, it is important to evaluate whether these drugs may modify arterial stiffness. In 23 patients, aged 32-70 years, with hypertension and hypercholesterolaemia, a doubleblind randomised study vs placebo was performed to evaluate whether atorvastatin was able to modify aortic stiffness, measured from aortic pulse wave velocity (PWV), after a 12-week treatment. The results revealed that atorvastatin did not change blood pressure, significantly lowered (Po0.003; o0.002) plasma total and LDL cholesterol, and increased aortic PWV by +8% (vs À2% under placebo) (P40.05). The percentage changes in plasma total and LDL cholesterol and in PWV were significantly and negatively correlated, independent of blood pressure level. The finding of increased aortic PWV after 12-week statin treatment agrees with studies in monkeys, indicating that, at the early phase of hypolipidaemic diet but not later, aortic PWV increases transiently as a consequence of the significant reduction of lipid vascular content. In conclusion, the present results support the possibility that statins might contribute to a change in arterial stiffness independent of blood pressure level, and suggest that long-term studies in humans are needed to evaluate the contribution of arterial elasticity to statin-induced vascular remodelling.

show abstract

Hemodynamic changes associated with reduction in total cholesterol by treatment with the HMG-CoA reductase inhibitor pravastatin

Cited by 72 publications

References 23 publications

The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia

The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia

Long-term effects of statins on arterial pressure and stiffness of hypertensives

Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study

Contact Info

Product

Resources

About