Hemodynamic Changes Caused by Glibenclamide in Isolated, Working, Erythrocyte Perfused Rat Heart

Legtenberg, Roger J.; Houston, R.; Smits, Paul; Oeseburg, B.

doi:10.1007/978-1-4615-4717-4_31

Cited by 2 publications

(2 citation statements)

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“…However, the changes in reperfusion coronary flow were not correlated with the resumption of contractile function in our study, as already described by others. 21 In summary, our study did not reveal any deleterious effect of the chronic combination of M and G on the functional recovery of the isolated diabetic rat heart subjected to ischaemia and reperfusion. We even found a slight, but significant increase in their residual contractile capacity.…”

Section: Discussionmentioning

confidence: 44%

Effects of chronic treatment with glibenclamide and/or metformin on the resistance to ischaemia of isolated hearts from Zucker Diabetic Fatty rats (ZDF/GMI-fa/fa)

Lavanchy

Christé²,

Cand³

et al. 2003

Diabetes & Vascular Disease

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The study was carried out to determine whether metformin (M) had any deleterious effect on the tolerance to ischaemia of the isolated diabetic rat when administered chronically in combination with glibenclamide (G). The male Zucker Diabetic Fatty (ZDF) rat served as a model of type 2 diabetes that resembles the human syndrome. Three groups of rats were treated for one month with M (100 mg/kg) or G (2 mg/kg) or G + M in their daily food. One group was untreated (C). Aortically perfused hearts were subjected to a 25-minute global low-flow ischaemia and a 30-minute reperfusion. Heart rate (HR), left ventricular developed pressure (LVDP), rate pressure product (RPP) and coronary flow (CF) were monitored. When compared to C hearts, the hearts from G + M rats showed improvements in HR, LVDP and RPP at the end of reperfusion. Hearts from G and M rats exhibited no difference. Myocardial glycogen stores at the end of in the three other groups. The study did not reveal any deleterious effect of the chronic G + M therapy on the functional recovery of the isolated diabetic heart submitted to ischaemia and reperfusion: indeed, an increase in residual contractile capacity was found.

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