Hemodynamic changes from stimulation of left ventricular baroreceptors

Pa, Chevalier; Weber, K.; Gw, Lyons; Nicoloff, DM; Ij, Fox

doi:10.1152/ajplegacy.1974.227.3.719

Cited by 29 publications

(15 citation statements)

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“…In a dog model a rapid injection of saline to increase left ventricular pressure triggered a hypotensive response [18]. Grech reported a profound decrease in systemic vascular resistance, decrease in venous return and hypotension during exercise in patients with AS and exercise related syncope [19].…”

Section: Discussionmentioning

confidence: 99%

Increased B-type natriuretic peptide is associated with an abnormal blood pressure response to exercise in asymptomatic aortic stenosis

Pelt

Kerr

Legget

et al. 2008

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Increased B-type natriuretic peptide is associated with an abnormal blood pressure response to exercise in asymptomatic aortic stenosis

Pelt

Kerr

Legget

et al. 2008

International Journal of Cardiology

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“…However, it should be noted that carotid sinus pressure was changed over a greater range than the ventricular pressure. It is difficult to relate these responses to those of earlier investigators largely because of the different techniques used to stimulate ventricular receptors and also because in many of the earlier studies responses were frequently not studied for long enough to evaluate steady-state changes (Mark, Abboud, Schmid & Heistad, 1973;Chevalier, Weber, Lyons, Nicoloff & Fox, 1974;Zelis, Lotysh, Brais, Peng, Hurley & Mason, 1977). In the present study we noted that changes in ventricular pressure resulted in alterations of vascular resistance in the whole animal which were better sustained than those in the perfused hindlimb reported by Challenger et al (1987).…”

Section: Discussionmentioning

confidence: 99%

Reflex Vascular Responses to Changes in Left Ventricular Pressure in Anaesthetized Dogs

1988

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SUMMARYIn dogs anaesthetized with chloralose, changes in left ventricular systolic pressure were induced using a preparation in which the pressure changes did not distend the aortic arch and in which left atrial and carotid sinus pressures were held constant. The systemic circulation was perfused at constant flow and drained from the venae cavae at constant pressure. An increase in left ventricular systolic pressure caused reflex dilatation of systemic resistance and capacitance vessels as indicated by decreases in arterial perfusion pressure and venous outflow. Responses were obtained when ventricular systolic pressure changed between 16 and 28 kPa (120-210 mHg). Responses to changes in ventricular pressure were reduced when the carotid sinuses were perfused at high pressures. These results indicate that changes in pressure in the left ventricle result in reflex changes in vascular resistance and capacitance and that responses are obtained to changes in ventricular pressure over a physiological range.

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“…Brown (1965) described nerves which ended in or near the coronary arteries and it is likely that the stimulus to these would have been changed during the present experiments. Occlusion of the coronary arteries induces reflex responses (Muers & Sleight, 1972;Thoren, 1972Thoren, , 1973Thames & Abboud, 1979 (Salisbury et al 1960;Ross et al 1961;Chevalier, Weber, Lyons, Nickoloff & Fox, 1974;Fox et al 1977;Emery, Estrin, Wahler & Fox, 1983). Sometimes the stimulus was applied long enough only for a transient response to be recorded (Mark et al 1973;Oberg & Thoren, 1973;Zelis et al 1977).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Vascular Responses to Changes in Left Ventricular Pressure in Anaesthetized Dogs

1987

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SUMMARYIn dogs anaesthetized with chloralose, cardiac receptors were stimulated by increases in left ventricular systolic pressure effected by changes in aortic root pressure. Left atrial and carotid sinus pressures were controlled. A large step increase in ventricular pressure resulted in transient decreases in heart rate, systemic arterial perfusion pressure and perfusion pressure to a vascularly isolated hind limb. The magnitudes of these responses were about three-quarters of those to either a large change in carotid sinus pressure or aortic root injection of 20,g veratridine. Steady-state responses were smaller. There was no significant change in perfusion pressure to a perfused cutaneous vein. Graded changes in ventricular systolic pressure showed that the most sensitive pressure range was between 20 and 24 kPa. These results indicate that changes in left ventricular pressure result in significant vasodilation in the hind limb and in other regions and that responses are obtained when the pressure is moderately elevated.

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Hemodynamic changes from stimulation of left ventricular baroreceptors

Cited by 29 publications

References 0 publications

Increased B-type natriuretic peptide is associated with an abnormal blood pressure response to exercise in asymptomatic aortic stenosis

Increased B-type natriuretic peptide is associated with an abnormal blood pressure response to exercise in asymptomatic aortic stenosis

Reflex Vascular Responses to Changes in Left Ventricular Pressure in Anaesthetized Dogs

Peripheral Vascular Responses to Changes in Left Ventricular Pressure in Anaesthetized Dogs

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