Hemodynamic Changes of Hepatic Veins as Predictors of Large Oesophageal Varices in Liver Cirrhotic Patients

Abdalla, Taghrid Mohamed; Shelfa, Wael; Elsayed, Saeed Bakry; Dawoud, Haitham

doi:10.21608/aeji.2014.16446

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…The degree of HVW abnormality among cirrhotic subjects also showed a significant relationship with hepatic dysfunction based on CTP class as noted in other studies. [ 6 23 27 28 ] In the study by Bhutto et al , the proportion of monophasic waveform by class was 90%, 73.91%, and 50% for Classes C, B, and A, respectively, which differed from that in this study which was 57.7%, 38.5%, and 3.8%, respectively. On the other hand, in the study by Antil et al , no patient in Class A had monophasic HVW while in Classes B and C, 33.3% and 87.0%, respectively, had monophasic HVW.…”

Section: Discussioncontrasting

confidence: 74%

Hepatic Function Predictive Value of Hepatic Venous Waveform versus Portal Vein Velocity in Liver Cirrhosis

Onwuka

Famurewa

Adekanle

et al. 2022

Journal of Medical Ultrasound

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Background: This study assessed the hepatic vein waveform (HVW) and mean maximum portal vein velocity (MM-PVV) on Doppler ultrasound in patients with liver cirrhosis (LC) and compared it with that of age and sex-matched controls. It correlated the degree of HVW abnormality and MM-PVV changes with liver function based on Child-Turcotte-Pugh (CTP) to determine which was more predictive of CTP. Methods: Sixty patients with LC and 60 healthy controls were consecutively recruited into this study. Each patient was classed based on the CTP system after relevant tests. Doppler evaluation of the hepatic vein (HV) and MM-PVV were performed. HVW obtained was classified either into triphasic, biphasic, or monophasic. Results: Sixty cirrhotic and 60 age-matched control subjects aged 19–69 and 18–69 years, respectively, completed this study. All control subjects had a normal HVW pattern while 46 (76.7%) cirrhotic subjects had abnormal HVW ( P < 0.001). The MM-PVV was significantly lower in cirrhotic subjects than in controls; 22.8 cm/s versus 33.6 cm/s ( P < 0.001). The degree of HVW abnormality among cirrhotics showed a significant positive correlation with CTP ( r = 0.283, P = 0.029). MM-PVV on the other hand showed no correlation with CTP class ( r = −0.124; P = 0.346). Linear regression showed that HVW was a significant predictor of hepatic dysfunction based on CTP. Conclusion: Changes in the waveform pattern of the HVs are a good predictor of the derangement of hepatic function in patients with LC than changes in PVV. HVW pattern could therefore serve as an adjunct to CTP class in hepatic function assessment.

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Section: Discussioncontrasting

confidence: 74%

Hepatic Function Predictive Value of Hepatic Venous Waveform versus Portal Vein Velocity in Liver Cirrhosis

Onwuka

Famurewa

Adekanle

et al. 2022

Journal of Medical Ultrasound

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“…Additionally, there was a correlation between the size of the esophageal varices and the patient's age, with larger OV being linked to elderly patients and smaller OV to younger persons. This could be because portal hypertension has more time to develop in the elderly (10) .…”

Section: Discussionmentioning

confidence: 99%

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

Omar,

Salama,

Saad

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: By measuring liver stiffness (LS) with transient elastography (TE), portal hypertension and the presence of oesophageal varices (OV) were investigated. In HCV-related cirrhotic individuals, fibroscan is capable of predicting the presence of esophageal varices. And probable categorization based on degree of hepatic rigidity.Objective: This research aimed to use fibroscan and a prospective grade based on degree of liver stiffness as a means of diagnosing esophageal varices earlier in people with cirrhosis caused by HCV. Methods: Ultrasonography was used to evaluate 250 Egyptian HCV-related cirrhotic patients, aged >18, with a BMI of < 35 and no history of ascites, GIT hemorrhage, HCC, abdominal collaterals, portal or splenic vein thrombosis. They classified the varices as group I (no varices), group II (little varices), and group III (big varices). Results: All Groups were matched for age and BMI. In group III, Platelet count was lower & MELD was higher significantly than in groups I &

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“…In addition, there was a link among the size of EVs as well as the age of the individual, with larger EVs being linked to older patients and smaller EV being linked to younger cases. This could be because portal hypertension and the development of large EV require more time to manifest in older patients (11) .…”

Section: Discussionmentioning

confidence: 99%

Simple Predictors of Gastro Esophageal Varices Bleeding in Cirrhotic Patients

2023

The Egyptian Journal of Hospital Medicine

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Background: Liver stiffness (LS), measured by transient elastography (TE), was correlated with portal hypertension as well as the presence of esophageal varices (EV). Objective: The aim of the current study was to examine non-invasive markers that serve as "predictors" of esophageal varices (EV) and variceal hemorrhage in individuals with liver cirrhosis. Patients and methods: A total of 250 Egyptian HCV associated cirrhotic persons, age more than 18, body mass index (BMI) under 35 with no history of ascites, GIT bleeding, HCC, abdominal collaterals, Portal, or splenic vein thrombosis by ultrasonography were recruited in our study. They were divided into Group I (no varices), Group II (small varices) and Group III (large varices). Results: All groups were age and BMI matched, in group III platelet count was lower and MELD score was higher significantly than groups I and II (115.4±41.6 vs 149.6±60.6 and 132.1±44.9) and (12.1±2.9 vs 9.1+2.5 and 10.1+2.2) respectively. Hemoglobin, platelet count and serum albumin were significantly decreased in group III in comparison with groups I and II (P-value <0.001), while serum bilirubin and INR levels were significantly more in group III than in groups I and II (P-value <0.001). AFP was significantly increased in group II than groups I and III (P-value 0.008). Conclusion:Our findings demonstrate the potential for using predictors to stratify cirrhotic individuals for the likelihood of developing extensive EV, hence enhancing the cost-effectiveness of screening endoscopy.

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Hemodynamic Changes of Hepatic Veins as Predictors of Large Oesophageal Varices in Liver Cirrhotic Patients

Cited by 3 publications

References 30 publications

Hepatic Function Predictive Value of Hepatic Venous Waveform versus Portal Vein Velocity in Liver Cirrhosis

Hepatic Function Predictive Value of Hepatic Venous Waveform versus Portal Vein Velocity in Liver Cirrhosis

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

Simple Predictors of Gastro Esophageal Varices Bleeding in Cirrhotic Patients

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